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Sino Biological
Sino Biological is listed as a mid sized business research supplier in the Scientist.com network, with 8 sites in 5 countries and 1 service area.
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Sites
8
Countries
5
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Affinity Maturation Use mutagenesis to optimize a complementary determining region and increase antibody affinity.
- Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
- Antibody Detection Quantitate, localize and visualize proteins and other antigens.
- Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
- Antibody Isotype Switching Modify antibody isotypes from any species to any human IgG isotype.
- Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Show all 19 in Antibodies
- Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
- Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
- Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...
- Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
- Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
- Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
- In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
- Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
- Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
- Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
- Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
- Recombinant Antibody Production Request services related to antibody production services.
- Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.
Biomarkers
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
- Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
Show all 92 services
Cell Culture and Characterization
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Services Most drug research projects routinely use a variety of cell research services including cell line construction, analysis of cells.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Chemical and Compound Analysis
- Ion Exchange Chromatography Separate and detect analytes.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Chemistry, Manufacturing and Controls (CMC)
- Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Discovery Chemistry
- Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
DNA & RNA
- DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
- DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Human Biological Samples
- Human Cell Lysates For requesting human Cell lysates.
In Vitro Assays
- Antivirals Measure anti-viral activity in biochemical and cell assays.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Assay Kits Can't find what you're looking for? Click here to submit a request to multiple vendors for assay kits.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
In Vitro Pharmacology
- Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Show all 16 in In Vitro Pharmacology
- Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
- Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
- Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
- Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
- Protein/Enzyme Targets For requesting Protein/Enzyme Targets
- Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
- RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Zebrafish Embryo Toxicity Use a single animal species to create one models of toxicity.
Other Specialty Toxicology
- Viral Testing Characterize viral products for functional activity and possible contamination.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- Cytokines Find recombinant cytokines or cytokine assays.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
- Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
- Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Show all 26 in Protein Sciences
- Integrated Protein Production Package Process an entire Protein Production Pipeline Project including: Gene/Oligo Synthesis, Cloning/Subcloning, Protein Expression, Protein Purification, Protein Analysis, and Protein Products from our bundle of suppliers
- Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
- Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
- Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
- Phage Display Use in vitro screening method to identify protein binding partners.
- Phosphorylation Analysis Identify phosphorylation sites in target proteins.
- Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
- Protein Engineering Alter the features or properties of a protein for a specific purpose.
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
- Protein Products Find native and recombinant proteins and peptides.
- Protein Purification Isolate native or recombinant proteins from a sample.
- Protein Sequencing Determine the amino acid sequence of protein or peptide.
- Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
- Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.
Other services
- New Request
Service areas:
Biology
Where it operates
Sites by country, with the cities in each.
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United States 4 sites
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Canada 1 site
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China 1 site
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Germany 1 site
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Japan 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
+Introduction+ Sino Biological Inc was founded in January 2007 in Beijing, P.R. China by biotech pioneer and worldwide expert, MIT institute professor, Dr. Daniel I.C. Wang and his former student, Dr. Liangzhi Xie. Sino Biological Inc is quickly becoming the leading global biological solution specialist, offering a comprehensive set of value-added and cost-effective premium quality solutions (services and reagents) to accelerate life science research and biological product development worldwide. Its customers include top-10 global pharmaceutical and biotech companies, small biotech...
Show the full description
+Introduction+
Sino Biological Inc was founded in January 2007 in Beijing, P.R. China by biotech pioneer and worldwide expert, MIT institute professor, Dr. Daniel I.C. Wang and his former student, Dr. Liangzhi Xie. Sino Biological Inc is quickly becoming the leading global biological solution specialist, offering a comprehensive set of value-added and cost-effective premium quality solutions (services and reagents) to accelerate life science research and biological product development worldwide. Its customers include top-10 global pharmaceutical and biotech companies, small biotech companies, and academic institutions worldwide.
+Business Focus+
- One-Stop Biology Services for protein and antibody discovery, research, development, production, and commercialization
- Affordable Premium Quality Reagents: Proteins, Antibodies, Kits, Transfection Reagents, Enzymes, Resins, and other Research Tools
+Missions:+
- To become the preferred centralized protein and antibody production lab serving the entire life science community worldwide
- To assist our customers to develop better and more life-saving therapeutic products, vaccines, and diagnostic methods at faster speed and cheaper cost
- To allow our customers to focus on what they do best and make their job easier and more efficient while saving cost
+Track Records+
- >400 recombinant monoclonal antibody production projects (10mg to 30 gram) for our customers worldwide in the past two years, More than 100 of these were intended for pre-clinical in vivo studies
- >600 recombinant proteins produced at bulk quantities in two years
- Produced H1N1 hemagglutinin protein from the 2009 swine influenza within 30-days of public release of the virus gene sequence
- First in developing high affinity and highly specific monoclonal antibodies to the 2009 H1N1 virus (no cross-reactivity to seasonal flu H1N1 viruses). Our ELISA kit can detect pg/well H1N1 HA protein.
+Capabilities and Capacities+
- Extensive expertise including molecular biology, protein and antibody production, rabbit and mouse monoclonal antibody generation, biological QC testing, biological formulation development and stability testing, and diagnostic assay development.
- >50 stirred tank bioreactors for cell culture and fermentation and purification systems.
- >30,000 L cell culture per year.
- >1000 recombinant monoclonal antibody production by transient transfection per year.
- >500 recombinant protein bulk production per year.
- >1000 rabbit and mouse monoclonal antibody development programs per year.
- No lead time for customer projects.
+Advanced Technology Platforms+
- HEK293 Transient Transfection Platform for Recombinant Protein & Antibody Production
- CHO Transient Transfection Platform for Recombinant Protein & Antibody Production
- CHO Stable Cell Line Platform for Recombinant Protein & Antibody Production
- Bacterial (E. Coli.) Platform for Recombinant Protein Expression & Production
- Baculovirus Insect Cell Platform for Recombinant Protein Expression & Production
- Protein and Antibody Purification Platform
- Rabbit Monoclonal Antibody Development Platform
- Mouse Monoclonal Antibody Development Platform
+Reliable, Speedy, High Quality, Cost-effective One-Stop Biology Services+
- Demonstrated to be the most reliable partner with close to 100% success rate.
- Unmatched speed of protein and antibody production is in the industry.
- Our quality of services have won praises from top pharmaceutical and biotech customers
- 40-80% of cost saving for services.
+Affordable Premium Quality Reagents+
We intend to produce bulk quantity of human proteins for every known human gene as long as it has potential research application, and develop high affinity antibodies for all proteins we produce. Our premium quality reagents are provided at significant cost-saving to our customers worldwide.
- High purity recombinant proteins, majority produced in mammalian cells
- High affinity antibodies: both rabbit and mouse monoclonal antibodies
- Majority antibodies developed with protein-based antigen
- Highly sensitive and specific ELISA kits
- Website
- www.sinobiological.com
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