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SMC Laboratories, Inc.

SMC Laboratories, Inc. is listed as a small business research supplier in the Scientist.com network, with 2 sites in 2 countries.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 2

Type of company: Small business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.

Bioimaging

Ab-Targeted Positron Emission Tomography Visualize sites of HIV replication that are difficult to access by tissue biopsies.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Cell Membrane Lipidomics Study the pathways and networks of membrane lipids.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.

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Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
TUNEL Assay Detect in situ DNA fragmentation.

Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.

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Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Insect Tissue Culture Grow insect cells.
Microsatellite Instability Analysis Compare allelic profiles and detect genomic instability.
Resin-based Histology Perform sectioning and histological analysis of epoxy/acrylic/polycarbonate-embedded samples.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Spent Media Analysis Measure chemical alterations, such as variations in amino acids, glucose, contaminants, and metabolites, in a cell culture medium throughout the culturing process.
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Stem Cell Methodologies Study Stem Cell characteristics.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.

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Chemical and Compound Analysis

Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.

Chemical and Compound Testing

Nutritional Testing Analyze food safety, vendor specifications, foreign substance identification processes and nutritional labeling.
Product Testing Ensure product quality standards are met.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Auto-immune Hepatitis Models Measure therapeutic endpoints in animal models with auto-immune hepatitis.

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Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Recombinant Nucleosomes Use as substrates in histone methyltransferase or acetyltransferase assays.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues

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RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Cellular Immunology Consulting Immunological activities of cells in experimental or clinical situations
Consulting Services Work with consultants who provide expert advice in various areas of research and technology.
Large Molecule Drug Development Consulting Develop large molecule drugs and complex biologics that have a therapeutic effect.
Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
Pathophysiology Consulting Request services related to Pathophysiology Consulting

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Pharmacogenetics Consulting Access genomic services required for clinical trials, such as genotyping, genetic variation testing and DNA isolation.
Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.

Human Biological Samples

HBS NASH For requesting HBS NASH

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression

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Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Glucose Release Assay Determine free glucose levels in biological samples.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.

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Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Test for effects on cell viability and proliferation
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.

In Vivo Pharmacokinetics

Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Animal Precision-Cut Lung Slice Model Acquire a fresh phenotypically-accurate model to study animal lung behavior.
Custom Model Development Develop a custom disease model.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.

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STAM™ model (NASH-HCC model mouse) At SMC, we have created the world’s first NASH to liver cancer model called STAM™. It shows the same progression from fatty liver (steatosis), to inflammation (NASH), to fibrosis, to Liver Cancer (hepatocellular...
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Nanotechnology

Drug Delivery Technology Create microstructures that enhance drug metabolism properties.
Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Pharmacology

In Vivo Pharmacology Study the effects of drug candidates in animal models

Protein Sciences

Carbohydrate Isolation Obtain pure monosaccharides, pure polysaccharides or related derivatives from samples.
Carbohydrate Isolation Protocol Development Design and optimize protocols for carbohydrate isolation.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.

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Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Native Protein Purification Purify native proteins from sources such as tissue & serum.
Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.

Other services

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Website: smccro-lab.com

Japan Tokyo 1 site
United States Newport Beach 1 site

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