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Charles River Laboratories

Charles River Laboratories is listed as a large business research supplier in the Scientist.com network, with 64 sites in 14 countries and 5 service areas.

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Sites 64

Countries 14

Type of company: Large business

Agricultural Sciences Compliance and Quality Control Measures

Exposure Tests which assess human health impact upon exposure of product.
Master Seed Testing Test your Master Seed Bank or Master Virus Seed Stock (MVSS) to insure that the Working Virus Bank or Working Virus Seed Stock (WVSS) remains the same genotype and phenotype as the initial Master Seed Bank.
OECD 106: Adsorption Study Estimate the adsorption/desorption behavior of a chemical on different soil types.
OECD 213: Honey Bee Acute Oral Toxicity Test Expose adult bees to a test chemical by feeding over 2 days for short-term toxicity assessment.
OECD 214: Honey Bee Acute Contact Toxicity Test Expose adult bees to a test chemical by topical application over 2 days for short-term toxicity assessment.
Pesticide Product Testing Use laboratory assays to evaluate the efficacy, safety and selectivity of a pesticide under GLP standards.

Agricultural Sciences Research & Development

Agro-product Storage Stability Testing Monitor agro-product changes over time to optimize packaging, storage conditions and product longevity.
Agrochemical Analytical Method Development Engineer sensitive and selective methods that meet GLP validation requirements to assess different agrochemical properties.
Agrochemical Identification Product identification and composition of pesticides; which includes fungicides, insecticide, herbicides and nematicides analysis.
Agrochemical Physio-Chemical Testing Conduct extensive property characterization of agrochemicals for geo-specific product approval and registration.
Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties

Animal Science and Welfare Audits

Veterinary Support Lab technician and veterinarian services providing support for model organisms and animal husbandry.

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Antibodies

AlphaLISA Quantification of analytes with high sensitivity, wider dynamic range and no wash steps involved.
Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...

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Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Integrated Antibody Development Package-US Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...
Recombinant Antibody Production Request services related to antibody production services.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.
Yeast Display Discover or optimize eukaryotic proteins and antibodies that contain post translational modifications

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.
Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.

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Magnetic Resonance Imaging Use MRI to obtain chemical and physical information about molecules and map the internal structure of an object.
Medical Imaging Visualize and analyze internal structures in animal models or patients.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Single Molecule Localization Microscopy Enable structural resolution of biological samples at the nanometer range using light in the visible spectrum.
SPECT-CT and PET-CT Imaging Get images that combine the spatial context of metabolic or biochemical activity with an anatomic image.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Bone Resorption Assay Functionally analyze osteoclast activity in vitro.

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Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Creatine Kinase (CK) Testing Detect and monitor pathologies associated with muscle inflammation or damage.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Cytogenetics Examine the structure and function of the cell, especially chromosomes.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Focus Forming Assay Use colorimetric or immunofluorescence-based readouts to quantify virions prior to any plaque formation.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Myeloperoxidase Testing Detect inflammatory markers and determine the risk for atherosclerosis or arterial plaque rupturing.
Osteoclasts Measure osteoclast activity and bone resorption in human, mouse or rat assays.
Oxidized Low Density Lipoproteins (LDL) Testing Identify the risk for metabolic syndrome and the development of associated diseases.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Peritoneal Fluid Analysis Determine the cause of fluid accumulation in the peritoneal space.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Authentication Verify the identity and purity of an experimental cell line or industrial culture.

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Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Services Most drug research projects routinely use a variety of cell research services including cell line construction, analysis of cells.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
cGMP Cell Banking Request information or a price quote for cGMP Cell Banking services
Endotoxin Characterization Identify specific molecular structure (e.g., Lipid A profiling), determine bacterial source/strain, and assess biological potency of endotoxins
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
H & E Services For requesting services related to H&E Services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
Lipofection Transfection of DNA/RNA using lipofection reagents to create lipoplexes.
Microsatellite Instability Analysis Compare allelic profiles and detect genomic instability.
Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.
Patient-Derived 3D Cell Culture (PD3D™) Tumor Models Use PD3D cultures to interrogate the mutation status of selected clinically relevant oncogenes and tumor suppressors.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
STR Profiling - Microsatellite Short Tandem Repeat Confirm cell line identity and detect cross-contamination.
Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.
Yeast Cell Culture Grow yeast strains or species.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Computed Tomography Visualize the internal features of solid objects.

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Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Hot Stage Microscopy (HSM) Visualize and characterize temperature-dependent phase transitions in pharmaceutical solids, polymers, and amorphous dispersions using polarized light microscopy coupled with a controlled thermal stage.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Isothermal Titration Calorimetry An ITC assay will be established and optimised for the affinity measurement of test substance to target molecule.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Photostability Measure drug degradation rates after exposure to various light sources.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structural Chemistry Examine the relationship between protein structure and function.
Ultrasound Tomography Use the transmission and acquisition of ultrasound waves to create a non-invasive technique for imaging.
UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.

Chemical and Compound Testing

Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.
Limulus Amebocyte Lysate (LAL) Test Detect bacterial endotoxins in raw materials used for the production of cosmetics products.
Product Testing Ensure product quality standards are met.

Chemistry, Manufacturing and Controls (CMC)

Advanced intermediates Sourcing advanced intermediates
Analytical Development and Validation Request services related to Analytical Development and Validation
API and drug product storage and release API and drug product storage and release
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)

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Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Bulk Manufacturing Find facilities for large-scale mass production.
Bulk Raw Materials Acquire raw materials in large volumes at wholesale pricing.
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Clinical supply management Clinical supply management
Compendial test methods Run Compendial test methods (e.g., KF)
Contract Manufacturing Services Find services for manufacturing, filling, packaging and labeling of finished drug products.
Crystallization studies Crystallization studies
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Fill and Finish Processing Confirm final product sterility, formulation and packaging in the biopharmaceutical process.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
ICH-compliant stability testing Perform ICH-compliant stability testing
Lipoparticle Technology Capture conformationally intact membrane proteins directly from the cell surface using lipoparticle technology.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Thermo Scientific iCAP Q ICP-MS Expand your analytical capabilities with this complete trace elemental analysis solution for your high-throughput lab.

Clinical Consulting

Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Biometrics Consulting Apply statistics and mathematics to drug discovery, clinical trials, and data analysis.
Biostatistics Consulting Apply statistical theory and mathematical principals to research
Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Data & Risk Management Determine the extent of the risk and the reliability of the data used to access the aforementioned risk.

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IND Writing Consulting Consulting for an Investigational New Drug Application
Product Testing Consulting Expert advice to evaluate the effectiveness, quality, and legitimacy of a given item or good.
Regulatory Compliance & Documentation Regulatory compliance describes the goal that organizations aspire to achieve in their efforts to ensure that they are aware of and take steps to comply with relevant laws, policies, and regulations.
Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.
Study Budgeting Consulting Request for Consulting Services

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Mass Balance Studies Design a study to determine the mass balance of drug-related material occurring administration of dose, the ratio of parent drug metabolite(s) in circulation, and the primary route of excretion of drug-related material.
Post-Marketing (Phase 4) Studies Conduct phase 4 studies for confirming unrecognized safety issues, investigating possible hazards or establishing the expected safety profile of a veterinary medicinal product under market conditions.
Regulatory Affairs Consulting Receive assistance ensuring compliance with regulatory requirements.
Statistical Analysis Planning Technical and detailed elaboration of the principal features of the analysis described in the protocol, and includes detailed procedures for executing the statistical analysis of the primary and secondary variables...

Data Science/Bioinformatics

Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
Proteome Data Analysis Find tools for analysis of homology and similarity, protein function and structural properties.

Developmental and Reproductive Toxicology (DART)

Bioelectronics Evaluate an application (e.g. device) that integrates biological materials and micro and nano-electronics.
Embryo-Fetal Development (EFD) Study (Segment II) Test drug candidate in Segment II toxicology services.
Fertility and Embryonic Development Study (Segment I) Test drug candidate in Segment I toxicology services.
Fertility and Embryonic Development Study (Segment I) - Mouse Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in mice.
Juvenile Toxicity Study - Other Species Conduct a study to determine the differences in toxicity between immature and mature systems in other species.
Juvenile Toxicity Study - Rat Conduct a study to determine the differences in toxicity between immature and mature systems in rats.

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Pre/Post-Natal Development (PPND) Study (Segment III) - Mouse Conduct a study to quantify the effect of your compound on fetal development, parturition, and post-natal development in mice.
Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.

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Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Auto-immune Hepatitis Models Measure therapeutic endpoints in animal models with auto-immune hepatitis.

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Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Bone Models Measure therapeutic endpoints in animal models of bone disorders.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Cartilage Repair Models Measure therapeutic endpoints in animal models of cartilage repair.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Cough Models Test the therapeutic efficacy of drug candidates in cough models.
Critical Care Models Diagnose and manage life-threatening conditions requiring sophisticated organ support and invasive monitoring.
Cyp2f2 Knockout Mouse Study Cyp2f2-mediated lung metabolism.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
Electroencephalogram EEG Models Record electrical activity along the scalp of animal models or human patients.
Emesis Models Measure therapeutic endpoints in animal models of emesis.
Excitotoxicity Models Measure therapeutic endpoints in animal models with excitotoxic pathology.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Leukemia Models Measure therapeutic endpoints in animal models of leukemia.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Macular Degeneration Models Use a single animal species to create one or more models for eye disease.
Microdialysis Models Measure the effect of drug candidates on neurotransmission in rat or mouse models.
Morris Water Maze Investigate spatial learning and memory in rodents.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neurological Neurological Pharmacology CROs specialize in in vivo high-throughput model systems to profile pre-clinical candidates for treat...
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
Ocular Inflammation Models Measure ocular inflammation in models of eye disorders such as uveitis and keratitis.
Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
Osteoporosis Models Measure therapeutic endpoints in animal models of osteoporosis.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
SHR/NCrl Rat Use a single animal species to create one or more disease models fior hematopoesis.
Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
Weanling Rat Use a single animal species to create one or more disease models for anemia.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
cDNA library construction Generate a library of recombinant cDNA clones.
Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
DNA Extraction Extract DNA from an original source.

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DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
Multiplex Cellular miRNA Assay Use Firefly™ technology for multiplex cellular microRNA profiling.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Whole Genome Bisulphite Seq Profile genome-wide DNA methylation.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Bioinformatics Consulting Consulting Services for the science of collecting and analyzing complex biological data
Cellular Immunology Consulting Immunological activities of cells in experimental or clinical situations
Chemistry, Manufacturing and Controls (CMC) Consulting Consultant services related to the development of pharmaceutical and biopharmaceutical drug products that are consistently effective, safe and high quality for consumers.
Chemoinformatics Consulting The use of computer and informational techniques applied to a range of problems in the field of chemistry.
Consulting Services Work with consultants who provide expert advice in various areas of research and technology.

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Large Molecule Drug Development Consulting Develop large molecule drugs and complex biologics that have a therapeutic effect.
Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
Pathophysiology Consulting Request services related to Pathophysiology Consulting
Pharmacogenetics Consulting Access genomic services required for clinical trials, such as genotyping, genetic variation testing and DNA isolation.
Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.
Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Effectiveness

Veterinary Clinical Field Trials Conduct single- or multi-site clinical trials according to VICH/GCP guidelines in livestock, poultry, and domestic pet species.

Environmental Assessment

Environment Fate Studies Evaluate the behavior of veterinary drugs and additives under controlled field and lab conditions.
Veterinary Environmental Assessment Assess whether environmental impacts may occur from the manufacture, use, or disposal of veterinary drugs.

Farm & Livestock Solutions

Serology/Immunology Testing for BSE/TSE

General in vivo Toxicology

Avian Toxicology Investigation Use toxicity tests to predict avian exposure risk, assess exposure effects or confirm product safety for registration.
Carcinogenicity Study - Mouse Conduct a repeat dose, chronic carcinogenicity study in mice to determine the tendency of your compound to produce tumors.
Carcinogenicity Study - Rat Conduct a repeat dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dose Range Finding Study - Dog /Canine Conduct a study to determine the dose range of your compound in dogs/canines.
Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.

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General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Dog / Canine Conduct a repeat dose study in dogs to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Cell Line and Cellular Services Promotion for Cells and Cell lines
Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
HBS Oncology For requesting Human biospecimens from Oncology indications
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human 3D cultures Provision of 3D culture of Human Primary Cells

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Human Adult Stem Cells Acquire human stem cells isolated from various adult tissues.
Human Buffy Coats Acquire fresh/frozen Buffy Coats based on patient demographics, disease stage, treatment and history.
Human Cell Products For requesting human cell by products like proteins, lysates, lysosomes etc
Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
Human Leukopaks Obtain enriched leukapheresis-derived products from normal peripheral blood.
Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.

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CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Multidrug Resistance Identify potential causes of drug-drug interactions.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.

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BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Assay Development Develop new cell based assays or modify existing ones.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
ImmunoSEQ Assay Unmask the identity of millions of T- and B-cell receptors in a single sample using bias-controlled multiplex PCR amplification, high-throughput sequencing, and sophisticated bioinformatics.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Microbiology Study microbes and their role in human health.
Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Reporter Virus Particles (RVPs) - Dengue Neutralization Assay Use Dengue Reporter Virus Particles to measure neutralizing antibodies against each of the four Dengue serotypes.
Thrombin Generation Tests Measure the tendency of a plasma sample to form thrombin upon the initiation of coagulation.
Viral Clearance Assays Measure the capacity to remove or inactivate infectious agents during the manufacturing process.
Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.
WBAL (Whole Body AL) Whole Body Autoradioluminography (WBAL) and related services can assist you in determining the metabolic fate of your test agen...

In Vitro Pharmacology

ATP Competitive Study Determine whether or not a compound is competitive with ATP.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.

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Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.
Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Fertilization Models Measure oocyte maturation, embryo development in culture and sperm fertilizing ability.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Nucleoside Transporter Assays Use biochemical, cell-based or in vivo assays to measure nucleoside transporter activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Comprehensive In Vitro Proarrhythmia Assay (CiPA) Use in vitro proarrhythmia assays to determine the proarrhythmic potential of new drugs.

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Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Microelectrode Array Cardiotoxicity Assays Use microelectrode array to measure cardiotoxicity-related activities.
Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
Zebrafish Embryo Toxicity Use a single animal species to create one models of toxicity.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine Conduct a bile duct cannulation (BDC) study in dogs/canines to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Monkey / Non-human Primate Conduct a bile duct cannulation (BDC) study in monkeys/non-human primates to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Other Species Conduct a bile duct cannulation (BDC) study in other species to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
Expired Air Study - Mouse Conduct a study to collect expired air and monitor its radioactivity content in mice.

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In Vivo Radiolabeled Metabolism Determine the qualitative and quantitative metabolism and/or degradation of an active ingredient in animals.
Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Minipig Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in minipigs.
Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Mass Balance Study - Other Species Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in other species.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Ocular Distribution Study - Dog / Canine Conduct a study to determine the distribution of your compound in ocular tissues of the dog/canine.
Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Ocular Distribution Study - Rabbit Conduct a study to determine the distribution of your compound in ocular tissues of the rabbit.
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
Quantitative Whole Body Autoradiography (QWBA) - Non-rodent Species Conduct a study to determine the tissue distribution of your compound radiolabeled compound in non-rodent species.
Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Mouse Efficacy Monotherapy Use mouse models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

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Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rabbit Conduct a pharmacokinetic screening study in rabbits that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.

Lab Supplies, Facilities, and Equipment

Lab Equipment Installation & Calibration Install new or refurbish used laboratory equipment and calibrate to reference standards.
Lab Equipment Maintenance & Repair Conduct repairs for laboratory equipment or routine and preventative maintenance.
Lab Equipment Maintenance Agreement Design contracts for laboratory equipment evaluation and maintenance requirements.
Lab Equipment Mechanical Design Obtain custom laboratory equipment modification and/or production.
Lab Equipment Rental Rent various scientific equipment commonly used in the laboratory.
Rent-to-Purchase Lab Equipment Obtain rent-to-purchase laboratory equipment and the corresponding contracts.

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Research Diets for Laboratory Animals Custom mixing and formulation of laboratory animal diets.

Management Optimization & Development Strategies

OECD Regulatory Development Consultation in safety testing, chemical notification and registry within OECD.

Market Access

Market Access Materials Find general strategies and methods used to market a pharmaceutical product or device.

Medical Communications

Strategic Medical Communication Development & Planning High-level planning to define the core scientific messages and the tactical strategy needed to effectively convey clinical data to key stakeholders over time.
Target Product Profile (TPP) A sponsor prepared document which summarizes the drug development program that is described in terms of the labelling concepts. This profile is a communication method used between the FDA and sponsor which can be used...

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.

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NMRI Mouse Use a single animal species to create one or more disease models for cachexia and hemophilia.
Non-Human Primate Models Use a single animal species to create one or more disease models.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
Pre-clinical Animal Surgery Conduct surgey in animals used as pre-clinical models.
Pseudopregnant CD1 Mouse Use a single animal species to create gene-modified mouse models.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Nanotechnology

Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.

Neurotoxicology

Single Dose Acute Neurotoxicity Study - Other Species Conduct a single dose study in other species to determine the neurotoxicty of your compound.
Single Dose Acute Neurotoxicity Study - Rat Conduct a single dose study in rats to determine the neurotoxicty of your compound.

Non-Human Biospecimen

Dog / Canine Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Guinea Pig Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Guinea Pig Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Monkey / Non-Human Primate / NHP Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Mouse Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.

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Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Peripheral Blood Mononuclear Cells (PBMCs) Acquire mouse PBMCs isolated from the blood tissue.
Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rat Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Rat Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Digestive System PDX Patient derived xenografts relating to organs and components of the digestive system. This includes, but is not limited to the Stomach, Intestines, Liver, Colon, Colorectal samples and Gastric samples.
Endocrine System PDX Patient derived xenografts related to the endocrine system. PDX related to glands controlling hormone regulation such as the Pituitary glands, Thyroid Glands, Adrenals, and Pancreas.

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Experimental Metastatic Models Measure therapeutic endpoints in animal models of experimental metastatic cancer.
Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Muscle Wasting Models Measure therapeutic endpoints in animal models of muscle wasting.
NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.
Noble Rat Use a single animal species to create one or more disease models for hematopoiesis.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Reproductive System PDX Patient derived xenografts relating to reproductive systems. This includes PDX from reproductive organs such as the Ovaries, Cervix, Breasts, Testes, Prostate, and Scrotum.
Urinary System PDX Patient Derived Xenografts relating to organs that comprise the Urinary system. This includes, but is not limited to, samples from the Kidneys, Liver, and Bladder.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.
Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Cutaneous Phototoxicity Study - Mouse Conduct a study in mice to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Hypoaspis Toxicity Tests Use Hypoaspis mortality to measure the short-term impact of a single or multiple exposure(s) to a test chemical.
Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
OECD 245: Honey Bee (Apis Mellifera L.), Chronic Oral Toxicity Test (10-Day Feeding) This Test Guideline describes a chronic oral toxicity test on adult worker honey bees under laboratory conditions over an exposure period of 10 days.

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Ototoxicity Study - Mouse Conduct a study in mice to determine the potential for your compound to cause hearing loss.
Phototoxicity Determine whether drug treatment causes light-activated toxic effects.
Raw Materials Testing Verify that raw materials are sterile and not contaminated by mycoplasma, virus or other microorganisms.
Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.
Tumorigenicity Testing Test tumor-forming properties of cell products.
Viral Testing Characterize viral products for functional activity and possible contamination.

Pharmacology

In Vivo Pharmacology Study the effects of drug candidates in animal models

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Product Development

Aerosol Products - Formulation Formulation services for aerosol products (e.g. hairsprays and spray antiperspirants)
Personal/Consumer Care Product or Service Request relating to the creation, testing or manufacturing of a personal care/consumer health/cosmetic product, ingredient or raw material.
Specialty (Other) - Formulation Other formulations for specialty products in personal care

Product Orders

Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
FRET/BRET Detect the location of proteins in living cells and their ability to interact with other proteins.

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Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Lentivirus Production Develop lentiviruses and production protocols.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Phage Display Use in vitro screening method to identify protein binding partners.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Binding Determine drug-protein binding interactions
Protein Engineering Alter the features or properties of a protein for a specific purpose.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Radioanalysis

Stand-alone Radioanalysis of Animal Pre-clinical Samples Conduct analysis of radioactive samples from preclinical radiolabeled studies.
Stand-alone Radioanalysis of Human Clinical Samples Conduct analysis of radioactive samples from clinical metabolism radiolabeled studies.

REACH Services

Acute Toxicity Study - Parasitic Wasps (Aphidius rhopalosiphi) This study is designed to estimate the acute toxicity of substances to Parasitic Wasps (Aphidius rhopalosiphi), including an option for reproductive toxicity.
Acute Toxicity Study - Predatory Mites (Typhlodromus phri) This study is designed to estimate the acute toxicity of substances to Predatory Mites (Typhlodromus phri), including an option for reproductive toxicity.
Acute Toxicity Study - Soil Mites This study is designed to estimate the acute toxicity of substances to Soil Mites, including an option for reproductive toxicity.
Ex Vivo REACH Assays Perform testing on cells or tissues cultured directly from a test organism
Hazard, Exposure and Risk Assessment Evaluate the known hazard of a test compound in conjunction with the expected quantity and frequency of exposure.
In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests

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In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 223: Avian Acute Oral Toxicity Test This Test guideline describes procedures designed to estimate the acute oral toxicity of substances to birds.
OECD 406: Skin Sensitisation This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application.
OECD 429: Skin Sensitisation (Local Lymph Node Assay) Assess the skin sensitization potential of chemicals.
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 437: Bovine Corneal Opacity and Permeability Test Method (BCOP) for Identifying Ocular Corrosives and Severe Irritants The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to classify substances as 'ocular corrosives and severe irritants'.
OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
OECD 475: Mammalian Bone Marrow Chromosomal Aberration Test The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese...
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.
REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Regulatory Affairs

Regulatory Submission Documents Request services related to the submission and writing of New Drug Applications (NDA), Investigational New Drugs (INDs), and Investigator Brochures (IB) to the FDA and other regulatory bodies.

Regulatory Consulting

Environmental Fate and Ecotoxicology Data Review Identify relevant endpoints for fate and behavior (metabolism and excretion, degradation and soil adsorption) and toxicity (soil organisms, aquatic organisms, and dung fauna) of animal health products.
Environmental Risk Assessment Conduct EU and US Environmental Assessment (ERA/EA) phases one and two according to VICH guidelines.
Toxicology Data Review Identify relevant toxicological endpoints for “No Observed (Adverse) Effect Level” (NO(A)EL) or “Lowest Observed (Adverse) Effect Level” (LO(A)EL).

Safety Pharmacology

Abuse and Dependence Liability Testing Determine the abuse or dependence potential of a therapeutic.
Abuse Liability Determine the dependence potential of a therapeutic.
CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Conditioned Place Preference or Aversion Study - Mouse Conduct a study to establish the aversion or conditioned place preference and determine the motivational effect of your compound in mice.
Dependence Potential Study - Rat Conduct a study to determine the dependence potential of your compound in rats.
Drug Discrimination Study - Rat Conduct a study to investigate the length of psychoactive effects of your compound in rats and conduct dose range finding for further studies.

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Endocrine Disruptor Screening Use biochemical, cell based or in vivo assays to identify and quantify endocrine-modulating agents.
Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Implanted Telemetry Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Implanted Telemetry Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
Implanted Telemetry Study - Other Species Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in other species.
Implanted Telemetry Study - Rat Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in rats.
Jacketed External Telemetry (JET) Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Jacketed External Telemetry (JET) Study - Minipig Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in minipigs.
Jacketed External Telemetry (JET) Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
Jacketed External Telemetry (JET) Study - Other Species Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in other species.
Locomotor Activity Assessment Study - Rat Conduct a study to determine the psychostimulant or sedative activity or your compound in rats.
Microelectrode Array Neurotoxicity Assays Use microelectrode array to measure neurotoxicity-related activities.
Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Repeat Dose Neurotoxicity Study - Other Species Conduct a repeat dose study in other species to determine the neurotoxicity of your compound.
Repeat Dose Neurotoxicity Study - Rat Conduct a repeat dose study in rats to determine the neurotoxicity of your compound.
Respiratory Toxicology Assess difficulty breathing, altered respiration, blood gas changes and blood pH issues due to adverse reactions.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Safety Pharmacology Latin Square Study - Dog / Canine Conduct a safety pharmacology study with a Latin square design in dogs/canines.
Safety Pharmacology Latin Square Study - Monkey / Non-human Primate Conduct a safety pharmacology study with a Latin square design in monkeys/non-human primates.
Safety Pharmacology Latin Square Study - Other Species Conduct a safety pharmacology study with a Latin square design in other species.
Safety Pharmacology Study with Functional Observational Batteries (FOBs) - Other Species Conduct a safety pharmacology study with functional oberservational batteries in other species.
Self Administration Study - Rat Conduct a study to investigate the potential addictive characteristics of your compound in rats.
Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.
Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.

Scientific Data Services

Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
Microbiome Data Analysis Determine the population composition of a microbial community and analyze its contribution to human or animal health.
Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
Omics Informatics Consulting Services for the analysis of large-scale molecular data sets.
WBA Technologies Request information or a price quote for WBA Technologies services. (global industry bodies driving the adoption of next-gen Wi-Fi, 5G, 6G, IoT, and OpenRoaming)

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.
Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Dog / Canine Conduct a single dose intranasal study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Target Animal Safety (TAS) Studies Evaluate potential harmful effects associated with the use of a new animal drug in a controlled setting.
Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.
Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
Consumer Care Testing and Substantiation Test personal care products using analytical, in vitro, and microbial test services
Cosmetics safety assessments Conduct safety assessments such as Microbiological quality, Margin of Safety, and information about the packaging material of cosmetic products.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.

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Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Microbiological Sterility Testing Test the presence of viable microorganisms.
Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
Ocular Irritation Test Use human subjects to determine whether a cosmetic product or ingredient can cause ocular irritation.
OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
OECD 442C: Direct Peptide Reactivity Assay (DPRA) Determine whether a test article satisfies the protein-binding criterion for skin sensitizers.
OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.
OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.
OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.
Raw Material Microbiological Testing Examples of which include Microbial Content using USP <61> and <62> and other standards, LAL Endotoxin, Ames Mutagenicity and Sterility.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Other services

Cell Microarray Technology Discover ligand-receptor interactions on the human cell surface.
Glaucoma Models Measure endpoints such as stereoscopic ophthalmoscopy, Goldmann tonometry and retinal ganglion cell counting.
IND Writing Receive assistance with materials for an IND application.
New Request  
Pfizer Sourcing Request Initiate a new request supported by a Pfizer Sourcing Group
Qube - High Throughput Screening Screen large compound libraries for ion channel blockers and modulators.

Service areas:

Biology DMPK Pharmacology Toxicology Manufacturing

United States Frederick, Ashland, Boston, Charleston, Chicago, Cleveland and 22 more 29 sites
United Kingdom Chinley, Harlow, Keele, Little Chesterford, Margate, Portishead and 1 more 7 sites
France Domaine des Oncins Nuelles, Ecully, Route de Pacy, Saint Germain-Nuelles, Zi De Brais CS 5 sites
Germany Erkrath, Freiburg Breisgau, Göttingen, Köln, Sulzfeld 5 sites
Canada Boisbriand, Montreal, Senneville, St. Constant 4 sites

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For more than 60 years, Charles River has provided tailored research models and laboratory animal support services, as well as preclinical and clinical services, to help our global partners accelerate their research and drug development efforts. Our offerings span the entire drug development process, from discovery through market approval, forming a seamless partnership throughout the process. From the global standardization of our research models to the high standards we set for our professional team and our state-of-the-art facilities and technologies, we can customize our products...

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From the global standardization of our research models to the high standards we set for our professional team and our state-of-the-art facilities and technologies, we can customize our products and services to meet your specific project needs. With multiple locations around the world, Charles River is the ideal partner for moving your product from animal to man in a rational, cost-effective, and timely manner.

Our partners include all of the major pharmaceutical and biotechnology companies worldwide, as well as government research centers and leading hospital and academic institutions. Our approach outstanding customer service and commitment to scientific excellence through best-in-class products, services, and procedures has led to long-standing relationships with many of our customers. Because of this commitment, we continue to count each of our top 20 customers from 1990 as valued partners today.

We provide the following animal models:

Rat Model - Wistar, Sprague Dawley, Long-Evans, Hairless, Buffalo, Zucker
Mouse Model - SCID, Nude, Albino, Elite, Black Swiss
Other Animal Models - gerbils, white rabbits, syrian hamsters, guinea pigs
Cryopreserved Oncology Models - Rat and Mice

Professional associations: AAPS, BIOCOM, BayBio, BioNJ, BioOhio, Life Science Tennessee, MassBio, SOT, SoCalBio
Website: www.criver.com

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