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Ricerca Biosciences LLC
Ricerca Biosciences LLC is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 5 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Chemical and Compound Analysis
- Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Chemical and Compound Testing
- Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.
Chemistry, Manufacturing and Controls (CMC)
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Discovery Chemistry
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
- Elemental Analysis Determine the elemental composition of compounds, biomolecules, and pharmaceuticals.
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
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Disease Models
- Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
- Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
- Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
In Vitro Assays
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Toxicology
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Model Development
- Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.
Protein Sciences
- Protein Binding Determine drug-protein binding interactions
Safety Pharmacology
- Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Specialty Dosing Routes
- Dermal Toxicology Assess toxicity in rodent dermal testing models.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Founded in 1986, Ricerca Biosciences offers a comprehensive suite of non-clinical discovery support and integrated R&D services to support drug candidate development from lead identification through IND and NDA submission. Biological capabilities include early pharmacokinetic and metabolism screening, pilot toxicology evaluations, IND/NDA-enabling toxicology and DMPK development of both small molecules and biologics. Supporting the chemical development needs, Ricerca offers synthetic, medicinal and process chemistry, radiochemistry, and cGMP API manufacturing of small scale clinical batches...
Show the full description
Founded in 1986, Ricerca Biosciences offers a comprehensive suite of non-clinical discovery support and integrated R&D services to support drug candidate development from lead identification through IND and NDA submission. Biological capabilities include early pharmacokinetic and metabolism screening, pilot toxicology evaluations, IND/NDA-enabling toxicology and DMPK development of both small molecules and biologics. Supporting the chemical development needs, Ricerca offers synthetic, medicinal and process chemistry, radiochemistry, and cGMP API manufacturing of small scale clinical batches through commercial API production, with complete analytical drug substance and drug product characterization.
Ricerca’s experienced scientists deliver world-class expertise and services to help shorten time to IND and bring molecules to the clinic faster. We have the capacity and integrated scientific capabilities, at our research site in Concord, Ohio, to deliver any size project. For the shortest and highest value based development program, from compound lead selection to regulatory filing, contact Ricerca.
- Website
- www.ricerca.com
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