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PharmaResources

PharmaResources is listed as a mid sized business research supplier in the Scientist.com network, with 1 site in 1 country and 3 service areas.

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Sites 1

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Type of company: Mid sized business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.

Cell Culture and Characterization

Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.

Chemical and Compound Analysis

Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.

Show all 26 in Chemical and Compound Analysis 20 more

Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Impurities in API Risk assessment Create a risk-based control strategy to determine any impurities in Active Pharmaceutical Ingredients (API).
Liquid Chromatography Separate substances using a mobile and stationary phase.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Photostability Measure drug degradation rates after exposure to various light sources.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Raman Spectroscopy Use spectroscopic technique to observe vibrational, rotational and other low-frequency modes in a system.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Solution Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solution samples.
Spray Drying Convert a liquid into a powder by rapidly drying the mixture and removing the moisture component.
Structural Chemistry Examine the relationship between protein structure and function.
Structural Elucidation Determine chemical structure of a compound. Characterization techniques include mass spectrometry, infrared spectroscopy and X-ray crystallography.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemistry, Manufacturing and Controls (CMC)

Advanced intermediates Sourcing advanced intermediates
Analytical Development and Validation Request services related to Analytical Development and Validation
API and Drug Product Stability Testing API and Drug Product Stability Testing.
API and Drug Product Storage and Distribution API and Drug Product Storage and Distribution.
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.

Show all 22 in Chemistry, Manufacturing and Controls (CMC) 16 more

Bulk Manufacturing Find facilities for large-scale mass production.
Bulk Raw Materials Acquire raw materials in large volumes at wholesale pricing.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Crystallization studies Crystallization studies
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Drug Substance and Drug Product Characterization and Manufacturing Drug Substance and Drug Product Characterization and Manufacturing.
Fill and Finish Processing Confirm final product sterility, formulation and packaging in the biopharmaceutical process.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Powder Blending Use automatic or semi-automatic powder blending machinery to produce consistent mixes.
Regulatory Starting Materials Sourcing regulatory starting materials (RSM)
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Tablet Manufacturing Use automatic or semi-automatic machinery to create various standard and non-standard tablets.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Show all 153 services 138 more

Data Science/Bioinformatics

In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.

Show all 26 in Discovery Chemistry 20 more

Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
Kinase Inhibitor Profiling Testing a drug compound against a large panel of kinases to measure its binding affinity, potency, and selectivity
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.

DNA & RNA

RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.

Drug Development

Small Molecule Drug Development Consulting Request consulting services related to small molecule development.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.

Show all 28 in In Vitro ADME 22 more

Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.

In Vitro Pharmacology

Aptamer Products Obtain pre-made aptamers for specific target binding.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.

In Vitro Toxicology

Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
Ocular Distribution Study - Dog / Canine Conduct a study to determine the distribution of your compound in ocular tissues of the dog/canine.
Ocular Distribution Study - Other Species Conduct a study to determine the distribution of your compound in ocular tissues of other species.
Ocular Distribution Study - Rabbit Conduct a study to determine the distribution of your compound in ocular tissues of the rabbit.
Ocular Distribution Study - Rat Conduct a study to determine the distribution of your compound in ocular tissues of the rat.

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Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rabbit Conduct a pharmacokinetic screening study in rabbits that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Show all 15 in In Vivo Pharmacokinetics 9 more

Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Product Development

Personal/Consumer Care Product or Service Request relating to the creation, testing or manufacturing of a personal care/consumer health/cosmetic product, ingredient or raw material.

Protein Sciences

Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Protein Binding Determine drug-protein binding interactions
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Scientific Data Services

Molecular Dynamics Software Run simulations that determine time-dependent behaviors of molecular systems.

Testing Services

Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Service areas:

Chemistry Pharmacology Toxicology

China Shanghai 1 site

PharmaResources provides lead generation, lead optimization, toxicity screening, manufacturing, and discovery route optimization.

Website: www.pharmaresources-us.com

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