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IPS Therapeutique
IPS Therapeutique is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country and 3 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Bioimaging
- SPECT-CT and PET-CT Imaging Get images that combine the spatial context of metabolic or biochemical activity with an anatomic image.
Biomarkers
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Disease Models
- Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
- Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
- Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
- Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
- Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Show all 21 in Disease Models
- Cough Models Test the therapeutic efficacy of drug candidates in cough models.
- Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
- Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
- Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
- Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
- Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
- LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
- LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
- Microsurgery in Rodents Outsource microsurgeries projects required for testing new therapies on a rodent model.
- Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
- Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
- Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
- Ventricular Tachycardia Models Measure therapeutic endpoints in animal models of ventricular tachycardia.
General in vivo Toxicology
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro ADME
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Show all 61 services
In Vitro Assays
- Anti-thrombin Assays Use clotting and chromogenic assays to detect and classify anti-thrombin deficiency.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
- Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Pharmacology
- In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
- In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Toxicology
- Cardiac Channels Measure the arrhythmia producing potential of test compounds.
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
- Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Show all 9 in In Vitro Toxicology
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
- Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
In Vivo Pharmacokinetics
- Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Model Development
- Fresh Functional Human Tissue Ion Channel Activity Assays Use fresh functional human tissue to assess ion channel activity with various compounds.
- Pre-clinical Animal Surgery Conduct surgey in animals used as pre-clinical models.
- Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
- STAM™ model (NASH-HCC model mouse) At SMC, we have created the world’s first NASH to liver cancer model called STAM™. It shows the same progression from fatty liver (steatosis), to inflammation (NASH), to fibrosis, to Liver Cancer (hepatocellular...
Oncology Models
- Animal Hypoxia Models Measure therapeutic endpoints in hypoxic animal models.
- Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
- Muscle Wasting Models Measure therapeutic endpoints in animal models of muscle wasting.
Safety Pharmacology
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Specialty Dosing Routes
- Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
- Repeat Dose Inhalation Study - Other Species Conduct a repeat dose inhalation study in other species to determine the toxicity and toxicokinetic behavior of your compound.
- Repeat Dose Inhalation Study - Rat Conduct a repeat dose inhalation study in rats to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Inhalation Study - Other Species Conduct a single dose inhalation study in other species to determine the toxicokinetic behavior of your compound.
- Single Dose Acute Inhalation Study - Rat Conduct a single dose inhalation study in rats to determine the toxicokinetic behavior of your compound.
- Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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Canada 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
IPS Therapeutique (IPST) is a Contract Research Organization dedicated to the preclinical evaluation of the efficacy and safety of new drugs using validated and highly predictive models. We leverage a unique combination of regulatory compliance and scientific insight to deliver innovative study design and customized development efforts. At IPST we believe each study is worthy of tailored protocols designed to maximize the scientific and strategic value of the data generated. Our fully integrated assessment of efficacy and safety successfully contributes to the faster development of safer...
Show the full description
IPS Therapeutique (IPST) is a Contract Research Organization dedicated to the preclinical evaluation of the efficacy and safety of new drugs using validated and highly predictive models. We leverage a unique combination of regulatory compliance and scientific insight to deliver innovative study design and customized development efforts.
At IPST we believe each study is worthy of tailored protocols designed to maximize the scientific and strategic value of the data generated. Our fully integrated assessment of efficacy and safety successfully contributes to the faster development of safer medicines. IPST is your reliable de-risking drug discovery partner.
Recognized for the quality and on-time delivery of our IND-enabling studies, at IPST we address the particular needs of start-up and mature biopharmaceutical companies looking for fast and cost-effective solutions to assess the QT Prolongation and the arrhythmogenic liabilities of their new compound(s) during preclinical development.
Our team of experienced scientists understand the challenges of drug development. Established in 1999, we have conducted more than 400 preclinical cardiac safety and efficacy studies and over 100 GLP-compliant studies in support of FDA, EMEA, Health Canada and MoHW.
We provide services for:
- Manual patch-clamp screening - hERG assay, ionic current inhibition, pre-IND
- Tension - isometric tissue, excitation-contraction coupling assay
- Automated patch-clamp screening - PatchExpress hERG
- Action Potential Kinetics - rat, guinea-pig, rabbit, dog hearts
- Website
- www.ipstherapeutique.com
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