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VivaCell Biotechnology GmbH

VivaCell Biotechnology GmbH is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 4 service areas.

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Sites 1
Countries 1

Services

What this research supplier says it provides, as listed in the Scientist.com network.

Type of company: Small business

Biomarkers

  • Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
  • Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
  • Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
  • Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
  • Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
  • Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Show all 12 in Biomarkers 6 more
  • Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
  • Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
  • Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
  • Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
  • TUNEL Assay Detect in situ DNA fragmentation.
  • Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Chemical and Compound Analysis

  • Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.

Disease Models

  • Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
  • Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
  • Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
  • Excitotoxicity Models Measure therapeutic endpoints in animal models with excitotoxic pathology.
  • Experimental Epilepsy Models Use chronic or induced animal models of epilepsy to test your drug candidate for therapeutic efficacy.
  • Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
Show all 13 in Disease Models 7 more
  • Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
  • Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
  • Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
  • Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
  • Pain Models Test therapeutic efficacy of drug candidate in pain model.
  • Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
  • Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
Show all 73 services 60 more

DNA & RNA

  • Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
  • Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
  • Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
  • RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.

Effectiveness

  • In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

Human Biological Samples

  • HBS Alzheimer's Acquire fresh, frozen, or fixed Alzheimer's tissues or other related Alzheimer's HBS.

In Vitro Assays

  • Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
  • Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
  • Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
  • Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
  • Cell Proliferation Measure cell number, cell viability and cell division.
  • Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Show all 11 in In Vitro Assays 5 more
  • In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
  • Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
  • Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
  • Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
  • Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.

In Vitro Pharmacology

  • Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
  • Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
  • G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
  • Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
  • Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
  • In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
Show all 13 in In Vitro Pharmacology 7 more
  • In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
  • In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.
  • In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
  • Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
  • Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
  • Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
  • Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.

In Vitro Toxicology

  • Cytotoxicity Test for effects on cell viability and proliferation
  • Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.

Protein Sciences

  • Cytokines Find recombinant cytokines or cytokine assays.
  • ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
  • Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
  • Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

REACH Services

  • OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
  • OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.

Testing Services

  • Collagen Production Test Test the regenerative ability of the skin under the influence of the test sample.
  • In Vitro Oral Care Product Testing Perform in vitro oral care product testing of dental products to evaluate safety and performance, including assessment for cleaning, brushing, whitening, stain removal, erosion, abrasivity and sensitivity.
  • In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
  • ISO 16217: Water Resistant Testing Evaluation of sunscreen's water resistance (40 and 80 minute)
  • OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
  • Skin Lightening Product Test Measure qualitative and quantitative changes in skin pigmentation under the influence of the test sample.
Show all 7 in Testing Services 1 more
  • UVA Protection Efficacy Evaluation of UVA protection using JCIA or ISO 24442

Other services

  • In Vitro Neurodegenerative Disease Platform Use an IVND platform to screen different compounds/drugs in a finely controlled synaptopathies scenario.
  • New Request  

Service areas:

Biology DMPK Toxicology Pharmacology

Source: Scientist.com supplier network

Where it operates

Sites by country, with the cities in each.

  • Germany Denzlingen 1 site

Source: Scientist.com supplier network (site locations)

About this supplier

In the supplier's own words, as listed in the Scientist.com network.

Vivacell Biotechnology GmbH is a privately owned contract-based research organisation (CRO) that provides specialised in vitro and in vivo models for testing and developing pharmaceutical and phytopharmaceutical compounds. VivaCell’s preclinical services include standard protocols and protocols adapted to the needs of the customers using a variety of in vitro and in vivo systems. VivaCell is combining highly qualified cellular and molecular biology knowledge and expertise in various fields with a focus on immunology and neurobiology. At VivaCell we offer you complete research projects from...

Show the full description

Vivacell Biotechnology GmbH is a privately owned contract-based research organisation (CRO) that provides specialised in vitro and in vivo models for testing and developing pharmaceutical and phytopharmaceutical compounds.

VivaCell’s preclinical services include standard protocols and protocols adapted to the needs of the customers using a variety of in vitro and in vivo systems.

VivaCell is combining highly qualified cellular and molecular biology knowledge and expertise in various fields with a focus on immunology and neurobiology.

At VivaCell we offer you complete research projects from basic R&D up to pre-clinical research (GLP) in one hand. Our clients do not have to gather the research data form various CROs.

We offer services for a large variety of indications including toxicology and drug interaction.

  • Immunomodulation: inflammation, common cold, arthritis, wound healing etc.
  • Viral entry / inhibition of neuraminidase (anti viral)
  • Oral care / Dental care
  • Central Nervous System: neurodegenration, mood, anxiety, depression, memory effects etc.

Dermatology / Cosmetics / Hair

  • Urinary: anti-inflammatory, 5α-reductase (benign prostatic hyperplasia)
  • Diabetes/Metabolic disease
  • Oncology / Angiogenesis
  • HIV-1 / AIDS
  • ADME (e.g. drug interaction, permeability studies)
  • Toxicology (e.g. genotoxicity, irritation)
  • Animal health and nutrition (pets/horses)

Mission of Viva Cell Biotechnology GmbH:

"Serving to solve Your research tasks"

Our aim is to serve our clients with the best quality by:

· Performing short time high quality studies at good prices
· The unique expertise of scientists assembled from the fields of
nutraceutical, botanicals, molecular and cellular biology and
phytochemistry not to be found in another company
· Individual and flexible study designs
· Scientific written reports including a conclusion and outlook
· Carrying out scientific tasks provided by the clients
· Bringing your scientific hypothesis to the bench
· Providing evidence of activity of your product
· Identification of new indications for your drugs
· Solving regulatory questions and demands
· Providing new arguments for marketing strategies

You need a drug target or the proof of a selective indication, we will try our best to help you !

Expertise:

VivaCell is combining highly qualified cellular and molecular biology knowledge and expertise in various fields with a focus on immunology, CNS, oral care, nutraceuticals and natural products.

We have demonstrated our expertise in with a variety of research projects, studying the efficacy of products in the CNS or peripheral systems in vitro and in vivo (see publication list).

Website
www.vivacell.de

Source: Scientist.com supplier network, written by the supplier

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Sources: Scientist.com supplier network.

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