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Bienta
Bienta is listed as a new startup research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: New startup
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Data Science/Bioinformatics
- In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.
Discovery Chemistry
- In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
- In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
General in vivo Toxicology
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro ADME
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Show all 10 in In Vitro ADME
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Show all 35 services
In Vitro Assays
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Protease Assay Measure protease activity in biochemical and cell-based assays.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Protein Sciences
- Protein Binding Determine drug-protein binding interactions
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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Ukraine 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Bienta is a trademark for preclinical biology services of Enamine, the world’s largest supplier of drug-like molecules for drug discovery research. Bienta is operating as a Contract Research Organisation providing biomolecular screening (HTS) services as well as comprehensive bioanalytical support of drug discovery projects, including in vitro ADMET (absorption, distribution, metabolism, excretion, toxicty) testing as well as pharmacokinetics (PK) and toxicity studies in animals.
- Website
- www.bienta.net
Work with Bienta on Scientist.com
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