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HitGen

HitGen is listed as a mid sized business research supplier in the Scientist.com network, with 1 site in 1 country.

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 1

Countries 1

Type of company: Mid sized business

Agricultural Sciences Research & Development

General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.

Chemical and Compound Analysis

Chiral Separation Purify therapeutically active isomers of drug candidates.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemistry, Manufacturing and Controls (CMC)

GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers

Data Science/Bioinformatics

Discovery Compound Screening Analytics Screening of an entire compound library directly against the drug target or in a more complex assay.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.

Show all 21 in Discovery Chemistry 15 more

Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Show all 51 services 36 more

DNA & RNA

Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.

In Vitro ADME

Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.

Protein Sciences

Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Protein Binding Determine drug-protein binding interactions
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Testing Services

Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

China Chengdu 1 site

HitGen Ltd is a life science company based in Chengdu, China. The company was founded by people with extensive scientific and managerial experience in pharmaceutical, CRO and related industries. The formation of the company has received major investment from China Chengdu Import and Export Group Co. Ltd, and enterprise grant support from Chengdu High Tech Zone. We are an innovation-driven and customer-focused company. HitGen has established a unique platform for early drug discovery research. With a focus on hit identification and lead generation during the early phase of drug discovery...

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We are an innovation-driven and customer-focused company. HitGen has established a unique platform for early drug discovery research.

With a focus on hit identification and lead generation during the early phase of drug discovery R&D, HitGen aims to be a leading provider in progressing projects from target to leads stage. To this end HitGen has established a core platform consisting of high quality, large DNA encoded compound libraries and research capabilities in protein expression and purification, in-vitro screening and affinity selection, chemical library design and synthesis, and medicinal chemistry.

HitGen also provides other biological reagents and services to support drug discovery research.

The company’s headquarters is based in the Tianfu Life Science Park of the Chengdu High-Tech Industrial Development Zone, one of the earliest state-level industrial development zones in China.

Website: www.hitgen.com

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