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University of Michigan, College of Pharmacy - Pharmacokinetics Core Laboratory
University of Michigan, College of Pharmacy - Pharmacokinetics Core Laboratory is listed as an academic core research supplier in the Scientist.com network, with 3 sites in 1 country.
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Sites
3
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Academic core
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
- Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Show all 9 in Chemical and Compound Analysis
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Clinical Trials
- Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
In Vitro ADME
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Show all 8 in In Vitro ADME
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Show all 25 services
In Vivo Pharmacokinetics
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
REACH Services
- OECD 417: Toxicokinetics Study Obtain data on absorption, distribution, metabolism, and elimination of test substances.
Testing Services
- Elevated Temperature Stability Determine the stability of a product at elevated temperature.
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
- Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
- Website
- pharmacy.umich.edu/pkcore
Where it operates
Sites by country, with the cities in each.
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United States 3 sites
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