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Firalis Molecular Precision

Firalis Molecular Precision is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Mid sized business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.

Biomarkers

Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body

Show all 27 in Biomarkers 21 more

Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Lipoprotein Associated Phospholipase A2 Testing Assess vascular inflammation and determine the risk for atherosclerosis or arterial plaque rupturing.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Microalbumin/Creatinine Ratio (MACR) Screen for kidney disease or monitor the extent of kidney damage from disease complication.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Multiplex Circulating miRNA Assay Profile miRNAs directly from just 10 μl of crude biofluid or 0.1 ng of purified RNA.
Myeloperoxidase Testing Detect inflammatory markers and determine the risk for atherosclerosis or arterial plaque rupturing.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Whole Transcriptome Amplification Amplify total RNA from a single cell.

Show all 130 services 118 more

Cell Culture and Characterization

Bacterial Cell Culture Culture and Grow bacterial cells.
Cell Culture Culture primary or immortalized cell lines.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Single Cell DNA Sequencing Examine genetic variations in a single cell.

Chemical and Compound Analysis

Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Liquid Chromatography Separate substances using a mobile and stationary phase.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.

Chemistry, Manufacturing and Controls (CMC)

Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.

Data Science/Bioinformatics

Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Protein Sequence Analysis Use software to predict protein structural and functional features and secondary structure components.

Discovery Chemistry

In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.

DNA & RNA

Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
ChIP-Sequencing Use chromosome immunoprecipitation to identify DNA-protein binding sites in a genome.
ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
De Novo Transcriptome Sequencing Identify new genes without the need for a reference genome sequence.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.

Show all 33 in DNA & RNA 27 more

DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Long Read Sequencing Long read sequencing is used in genomics to sequence long fragments of DNA, enabling the ability to span complex regions of the genome.
Metagenomic Sequencing Sequence genetic material recovered directly from environmental samples
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
Methylation Specific PCR Determine the methylation status of a CpG site without the need for base-specific endonucleases.
mtDNA Sequencing Use next-generation sequencing (NGS) technology to detect and analyze mitochondrial mutations.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Targeted Sequencing/Resequencing Detect variations in a genome subset.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Bisulphite Seq Profile genome-wide DNA methylation.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Metabolism and Pharmacokinetics (DMPK)

Biomarkers DMPK Biomarker DMPK and gene analysis services are critical tools in evaluating patients and discovery of new therapeutics.

General Marketing

Database Management Software Facilitate the collection, tracking and processing of biological facts, statistics and observations.

Human Biological Samples

HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.

In Vitro ADME

Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Anti-thrombin Assays Use clotting and chromogenic assays to detect and classify anti-thrombin deficiency.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

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Cell Proliferation Measure cell number, cell viability and cell division.
Glucose Release Assay Determine free glucose levels in biological samples.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
Von Willebrand Factor Analysis Detect and classify the Von Willebrand disease sub-type.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.

Show all 16 in In Vitro Pharmacology 10 more

Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.
Low Density Lipoprotein (LDL) Uptake Assay Investigate low density lipoprotein uptake and regulation at the cellular level.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Native Protein Purification Purify native proteins from sources such as tissue & serum.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.

Show all 12 in Protein Sciences 6 more

Protein Identification Uncover or confirm the identity of a protein.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Scientific Data Services

Database Integration Convert bioinformatics results from multiple data sources (DSs) into a single operational format.
In Silico Genomics/Transcriptomics Data Analysis Interpret DNA sequencing and microarray data.

Other services

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Website: precursion-biosciences.com

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