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Solvias
Solvias is listed as a large business research supplier in the Scientist.com network, with 5 sites in 4 countries and 1 service area.
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Sites
5
Countries
4
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
- Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
Bioimaging
- Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
- Scanning Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Biomarkers
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Cell Culture and Characterization
- Cell Culture Culture primary or immortalized cell lines.
- Endotoxin Characterization Identify specific molecular structure (e.g., Lipid A profiling), determine bacterial source/strain, and assess biological potency of endotoxins
- Spent Media Analysis Measure chemical alterations, such as variations in amino acids, glucose, contaminants, and metabolites, in a cell culture medium throughout the culturing process.
Show all 114 services
Chemical and Compound Analysis
- Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Atomic Absorption Analysis Measure the elemental composition of a diverse array of samples.
- Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.
- Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
- Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Show all 30 in Chemical and Compound Analysis
- Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
- Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
- Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
- Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
- Ion Exchange Chromatography Separate and detect analytes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
- Photostability Measure drug degradation rates after exposure to various light sources.
- Process Residual Impurities Detection Measure trace levels of impurities.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Raman Spectroscopy Use spectroscopic technique to observe vibrational, rotational and other low-frequency modes in a system.
- Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
- Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- Structural Spectroscopy Assess conformational transitions that proteins undergo in response to changes in their environment.
Chemical and Compound Testing
- Limulus Amebocyte Lysate (LAL) Test Detect bacterial endotoxins in raw materials used for the production of cosmetics products.
- USP <85> Bacterial Endotoxin Test Test to detect or quantify bacterial endotoxins that may be present in or on a sample.
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- API and Drug Product Stability Testing API and Drug Product Stability Testing.
- API and drug product storage and release API and drug product storage and release
- API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
- API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
- API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
Show all 17 in Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Compendial test methods Run Compendial test methods (e.g., KF)
- Crystallization studies Crystallization studies
- Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- ICH-compliant stability testing Perform ICH-compliant stability testing
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Process Development Optimize existing synthesis methods or develop alternate synthesis strategies.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Discovery Chemistry
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Leachable and extractable testing Leachable and extractable testing
DNA & RNA
- Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
- Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
- Genotyping Examine a DNA sequence to identify specific genetic varients .
Show all 14 in DNA & RNA
- qPCR Analysis Measure the accumulation of PCR products in real time.
- RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
- RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
- Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
- Targeted Sequencing/Resequencing Detect variations in a genome subset.
- Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Drug Development
- Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Food Safety & Regulations
- Water Activity Determine water activity in consumer healthcare products involving a USP or FCC monograph.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Show all 8 in In Vitro Assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
Other Specialty Toxicology
- Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Protein Sciences
- Analytical Ultracentrifugation Characterize the interactions and properties of macromolecules in solution.
- Cytokines Find recombinant cytokines or cytokine assays.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
- N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Show all 11 in Protein Sciences
- Protein Sequencing Determine the amino acid sequence of protein or peptide.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
- Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
- Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
- X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Elevated Temperature Stability Determine the stability of a product at elevated temperature.
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
- Microbiological Sterility Testing Test the presence of viable microorganisms.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Other services
- Modified Supercritical Anti-Solvent Technology Generate crystals and particles in a thermodynamically stable and scalable manner.
- New Request
Service areas:
Chemistry
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
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France 1 site
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Netherlands 1 site
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Switzerland 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
The name is synonymous with a promise: Solvias stands for solutions (Latin solutio) as well as path (Latin via). Solvias seeks and finds new paths to reach new solutions. Solvias offers increased capacity and profound know-how for analytical and chemical development. Its experience and proven track record gives confidence that projects will be expertly performed and delivered on time. With its services, products and technologies Solvias provides integrated solutions to enhance the value-chain for customers in the pharmaceutical and biopharmaceutical industry worldwide. The service portfolio...
Show the full description
The name is synonymous with a promise: Solvias stands for solutions (Latin solutio) as well as path (Latin via). Solvias seeks and finds new paths to reach new solutions. Solvias offers increased capacity and profound know-how for analytical and chemical development. Its experience and proven track record gives confidence that projects will be expertly performed and delivered on time. With its services, products and technologies Solvias provides integrated solutions to enhance the value-chain for customers in the pharmaceutical and biopharmaceutical industry worldwide.
The service portfolio covers:
• Analytical Services
• Biopharmaceutical Analysis
• Solid-Sate Services: Polymorphism, Salts, and Crystallization
• Chemical Development and API Manufacturing up to phase II
• Catalysis
• Process Analytical Technology
The Laboratories have been successfully inspected by more than 300 customers, the Swiss authorities and the FDA. The authorization of Swissmedic, the Swiss Agency for Therapeutic Products, allows Solvias to perform pharmaceutical analyses and to manufacture active pharmaceutical ingredients (API) for use in clinical trials within the standard of Good Manufacturing Practice (GMP). Solvias is as a privately held company located in Kaiseraugst close to Basel (Switzerland). The teamwork and cooperation of more than 250 highly qualified employees lead to successful analytical and chemical development projects.
- Website
- www.solvias.com
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