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Eurosafe

Eurosafe is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 1

Countries 1

Type of company: Small business

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.

Cell Culture and Characterization

Cell Culture Culture primary or immortalized cell lines.
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.

Chemical and Compound Analysis

Adsorption/Desorption Studies Obtain data on groundwater risk assessment.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Light Sheet Fluorescence Microscopy Use a planar sheet of light to section transparent tissues and generate a 3D image.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.

Show all 10 in Chemical and Compound Analysis 4 more

Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.

Show all 109 services 93 more

Chemical and Compound Testing

Product Testing Ensure product quality standards are met.

Chemistry, Manufacturing and Controls (CMC)

Plant Extracts Acquire plant extracts, such as lutein, lycopene, and quinine, to use as ingredients in consumer healthcare products.
Subcellular Fraction Test System Obtain human, minipig, mouse, or rat dermal microsomes as in-stock standard test systems for the development of safer topical and transdermal products.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Consumer Healthcare Product Trials Conduct clinical research to ensure the safety and efficacy of consumer healthcare products used for oral care, skin care, nutrition, and hair care.

Data Science/Bioinformatics

In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.
In Silico Protein Modification Analysis Use computational methods to predict the behavior of modified proteins.
In Silico Protein Sequence Analysis Use software to predict protein structural and functional features and secondary structure components.

Discovery Chemistry

Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.

Show all 8 in Discovery Chemistry 2 more

QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.

DNA & RNA

qPCR Analysis Measure the accumulation of PCR products in real time.

General Marketing

Database Management Software Facilitate the collection, tracking and processing of biological facts, statistics and observations.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).

Show all 27 in In Vitro ADME 21 more

CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro SPF (Sun Protection Factor) Testing Use in vitro test methods to measure the UVA protection performance of sun protection products.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.

In Vitro Pharmacology

ATP Competitive Study Determine whether or not a compound is competitive with ATP.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
Substrate Competitive Study Determine whether or not a compound is competitive with a substrate.

Show all 8 in In Vitro Pharmacology 2 more

Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Other Specialty Toxicology

Phototoxicity Determine whether drug treatment causes light-activated toxic effects.

Protein Sciences

Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Protein Binding Determine drug-protein binding interactions

Raw Materials

Oral Health Care Product Ingredients Acquire ingredients for making oral healthcare products.

REACH Services

OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.

Scientific Data Services

In Silico Genomics/Transcriptomics Data Analysis Interpret DNA sequencing and microarray data.
In Silico Metagenomics/Metatranscriptomics Data Analysis Use software to analyze genomic information from multiple environmental sources.

Testing Services

Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Human Repeat Insult Patch Test (HRIPT) Examples of which include Topical Irritation, Allergenicity, Phototoxicity and Photoallergy testing.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Ocular Irritation Test Use human subjects to determine whether a cosmetic product or ingredient can cause ocular irritation.
OECD 442C: Direct Peptide Reactivity Assay (DPRA) Determine whether a test article satisfies the protein-binding criterion for skin sensitizers.
OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.

Show all 11 in Testing Services 5 more

OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
Skin Elasticity Testing Measure the skin's ability to resist pressure (firmness) and its ability to return to its original position pre- and post-treatment.
Skin Lightening Product Test Measure qualitative and quantitative changes in skin pigmentation under the influence of the test sample.
Tolerance Test Under Dermatologic Control Evaluate the acceptability and skin tolerance of a cosmetic product.
Trans-Epidermal Water Loss (TEWL) Use a sensing electrode encased in a chimney to measure the relative humidity percentage at the skin surface.

Other services

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Service areas:

DMPK Toxicology

France Saint-Grégoire 1 site

Xenoblis offers ADMET services including skin/intestinal permeability studies, blood brain barrier studies, genotoxicity, cytotoxicity, metabolite characterization, and protein binding studies.

Website: www.eurosafe.com

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