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AIBioTech

AIBioTech is listed as a new startup research supplier in the Scientist.com network, with 1 site in 1 country and 4 service areas.

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Type of company: New startup

Antibodies

Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...

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Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
In Silico Humanization Predict epitope binding specificity, increase in vivo half-life and allow rapid modeling and humanization of antibodies.

Bioimaging

Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Nano-Imaging Visualize and characterize samples at the nano-scale.

Biomarkers

Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Cytogenetics Examine the structure and function of the cell, especially chromosomes.

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Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Genomics Genomic services including applications to DNA (*sanger sequencing, whole genome amplification, library screening, cloning, sub-cloning, and DNA isolation*) and RNA (*microRNA analysis, RNA isolation, qRT-PCR, mRNA...
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Insulin Autoantibodies (IAA) Testing Detect the risk or presence of type 1 diabetes in early childhood.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Osteoclasts Measure osteoclast activity and bone resorption in human, mouse or rat assays.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.

Show all 288 services 274 more

Cell Culture and Characterization

Bacterial Cell Culture Culture and Grow bacterial cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Authentication Verify the identity and purity of an experimental cell line or industrial culture.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Services Most drug research projects routinely use a variety of cell research services including cell line construction, analysis of cells.

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Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Single Cell DNA Sequencing Examine genetic variations in a single cell.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Chemical Stability Measure the stability of small molecules in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.

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GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
Natural Product Libraries Find microbial, botanical and marine sources of natural products.
NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Photostability Measure drug degradation rates after exposure to various light sources.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemical and Compound Testing

Nutritional Testing Analyze food safety, vendor specifications, foreign substance identification processes and nutritional labeling.

Chemistry, Manufacturing and Controls (CMC)

Analytical Development and Validation Request services related to Analytical Development and Validation
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.

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Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.

Data Science/Bioinformatics

In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Nucleic Acid Microarray Analysis Use software to visualize and evaluate gene activity in response to various stimuli.

Developmental and Reproductive Toxicology (DART)

Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Certified Standards Find certified standards for assays, tests and services.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.

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Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Natural Product Screening Screen large natural product collections for therapeutic activity.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
UV and IR Profiling Analyze the integrity of a compound or large biomolecule.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.
Hepatitis C Virus Models Measure therapeutic endpoints in animal models of Hepatitis C virus infection.
Malaria Models Measure therapeutic endpoints in animal models of malaria.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.

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Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.

DNA & RNA

Amplicon - HLA Typing Use an amplicon sequencing method to identify allelic variation within the HLA genes.
Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
cDNA library construction Generate a library of recombinant cDNA clones.
Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
ChIP-Sequencing Use chromosome immunoprecipitation to identify DNA-protein binding sites in a genome.

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ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
De Novo Genome Sequencing Determine the DNA sequence of uncharacterized genomes.
DNA Extraction Extract DNA from an original source.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
Genotyping Examine a DNA sequence to identify specific genetic varients .
In Situ Hybridization Localize specific nucleic acid targets using labeled complementary probes.
Metagenomic Sequencing Sequence genetic material recovered directly from environmental samples
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
non-coding RNA Synthesis Prepare non-coding RNA in vitro.
Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
Poly (A) tail Length Profiling (PAL-Seq) Conduct high-throughput sequencing of individual mRNA poly (A) tails.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
RNAi Pathway Analysis Use high-throughput RNAi genetic screens to elucidate relevant signaling pathways.
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Targeted Sequencing/Resequencing Detect variations in a genome subset.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Amplification (WGA) Amplify an entire genome from a single cell.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.

General Marketing

Database Management Software Facilitate the collection, tracking and processing of biological facts, statistics and observations.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.

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Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.

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High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Human Immuno-deficiency Virus Infection CDx Design and validate companion diagnostics for HIV infection that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
Microbiology Study microbes and their role in human health.
Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

In Vitro Pharmacology

Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.

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In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.

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Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.
Zebrafish Embryo Toxicity Use a single animal species to create one models of toxicity.

In Vivo Pharmacokinetics

Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Model Development

Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.

Nanotechnology

Nanoparticle Synthesis Create nano-level structures with unique features.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.

Other Specialty Toxicology

Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Phototoxicity Determine whether drug treatment causes light-activated toxic effects.
Raw Materials Testing Verify that raw materials are sterile and not contaminated by mycoplasma, virus or other microorganisms.
Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.
Tumorigenicity Testing Test tumor-forming properties of cell products.
Viral Testing Characterize viral products for functional activity and possible contamination.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Product Orders

BioTx General Biotherapeutics analyze therapeutics and drugs via biological means and recombinant DNA. Pre-clinical sample bioanalysis and le...
Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.

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Phage Display Use in vitro screening method to identify protein binding partners.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Analysis Analyze the structure, activity, interactions and distribution of proteins.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Engineering Alter the features or properties of a protein for a specific purpose.
Protein Products Find native and recombinant proteins and peptides.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Yeast Two Hybrid Search novel interactions or confirm hypothesized protein-protein interactions using pairwise assays.

REACH Services

OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
OECD 475: Mammalian Bone Marrow Chromosomal Aberration Test The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese...
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.
REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Safety Pharmacology

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Data and Text Mining Derive structured data from free text in order to become accessible for data-mining algorithms.
Database Integration Convert bioinformatics results from multiple data sources (DSs) into a single operational format.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
In Silico Genomics/Transcriptomics Data Analysis Interpret DNA sequencing and microarray data.

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Software Tools Software tool for statistical analysis, data mining, genome annotation or NGS data analysis.
Systems Biomedicine Analyze complex interactions in biological systems with interdisciplinary scientific teams.
Systems Network Analysis Analyze and visualize molecular pathways including gene regulatory, protein-protein and drug-target networks.

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Service areas:

Biology Chemistry DMPK Toxicology

United States Richmond 1 site

AIBioTech provides drug discovery and diagnostic development organizations a broad range of world-class laboratory services to bring new products to market. p<>. Located in a 32,000 square foot laboratory in Richmond, Virginia, AIBioTech is a comprehensive life-sciences Contract Research Organization which provides reliable expertise and cutting-edge technologies that are not available from other companies. p<>. As an expert core laboratory, we provide consultation on experimental design and offer comprehensive services under GLP and non-GLP compliance. These services are offered...

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AIBioTech provides drug discovery and diagnostic development organizations a broad range of world-class laboratory services to bring new products to market.

p<>. Located in a 32,000 square foot laboratory in Richmond, Virginia, AIBioTech is a comprehensive life-sciences Contract Research Organization which provides reliable expertise and cutting-edge technologies that are not available from other companies.

p<>. As an expert core laboratory, we provide consultation on experimental design and offer comprehensive services under GLP and non-GLP compliance. These services are offered individually or can be integrated to support product development from discovery-to-market with full Regulatory Support under FDA GLP Guidelines 21 CFR 58.

p<>. AIBioTech offers integrated programs in many areas, including: Molecular Biology, Immunochemistry, Protein Expression and Characterization, Peptide Synthesis and purification, Mass Spectrometry and other Bio-analytical services, Assay Development and Validation, Microbiology, Virology and Biosafety testing (up to BSL3 facilities), Clinical Testing Services, Clinical Support Services, Genetic Identity and Forensic Analysis.

Some services that we provide are:

Cardiac Genetics - Factor V Leiden Assay, ApoE Genotyping
Antibody Structural Characterization - spectral analysis, chain separation, thermal stability
Peptide Production - individual, multiple arm, epitope peptides
Biophysical Characterization - SEC, circular dichroism, spectroscopy
Biodefense Management and Testing - pathogen testing, fungi identification
Sanger Sequencing - performed with AB 3100, 3130, 3500
HPV Genotyping - detect 14 prevalent HPV genotypes

Website: www.grangergenetics.com

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