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KCAS
KCAS is listed as a mid sized business research supplier in the Scientist.com network, with 5 sites in 3 countries and 1 service area.
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Sites
5
Countries
3
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Agricultural Sciences Research & Development
- Molecular Markers Use of molecular diagnostics to analyze biological markers in the genome and proteome.
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Biomarkers
- Autoantibody Testing Screen for the presence of an autoimmune disorder.
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Show all 25 in Biomarkers
- Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
- Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
- Microfluidics-Based Biomarker Isolation and Detection Isolate and detect rare biomarkers in blood samples, such as CTCs, cfDNA, and exosomes.
- NBE Biomarkers Request information or a price quote for NBE Biomarkers services
- Peptide Bioanalysis Analyze the structure of Peptides.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
- Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
- Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
- Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Cell Culture and Characterization
- Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
- Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Chemical and Compound Analysis
- Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
- Atomic Absorption Analysis Measure the elemental composition of a diverse array of samples.
- Bioanalysis Bioanalysis involves the determination of the concentration of test compounds in biological samples including plasma, urine, an...
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Show all 12 in Chemical and Compound Analysis
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Nano-High Performance Liquid Chromatography Separate and detect low levels of analytes.
- NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Show all 89 services
Chemistry, Manufacturing and Controls (CMC)
- Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Clinical Trials
- Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
- Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.
Data Science/Bioinformatics
- Clinical Biomarker Analysis An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
- Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
DNA & RNA
- ddPCR-Based Plasma Genotyping Perform noninvasive tumor genotyping.
- Methylation Specific PCR Determine the methylation status of a CpG site without the need for base-specific endonucleases.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Human Biological Samples
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
In Vitro ADME
- Cell Fractionation Isolate organelles and subcellular components.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Show all 7 in In Vitro ADME
- Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- ELISpot Assay and Testing Detect low levels of antigens.
- HTS Assay Development Develop assays to use in high throughput screening.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Show all 9 in In Vitro Assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
- Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Show all 7 in In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Nanotechnology
- Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.
Protein Sciences
- Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
- Cytokines Find recombinant cytokines or cytokine assays.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Show all 8 in Protein Sciences
- Quantitative MS Quantify small and large molecules in the pg/ml range
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Other services
- New Request
Service areas:
DMPK
Where it operates
Sites by country, with the cities in each.
-
United States 3 sites
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Australia 1 site
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France 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
KCAS is a bioanalytical and immunoanalytical contract research organization (CRO) focused on developing and validating robust small molecule, large molecule and biomarker methods for preclinical and clinical studies. Over the past 35 years, our scientific team has developed 4,600+ non-proprietary and 900+ generic assays. To learn more about KCAS Bioanalytical Services, please visit www.kcasbio.com.
- Professional associations
- AAPS, KansasBio, MassBio
- Website
- www.kcasbio.com
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