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Offspring Biosciences
Offspring Biosciences is listed as a small business research supplier in the Scientist.com network, with 3 sites in 1 country.
View Offspring Biosciences on Scientist.com
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Sites
3
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody Detection Quantitate, localize and visualize proteins and other antigens.
- Immunodetection Use antibodies to identify a protein or antigen.
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
- In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
- Medical Imaging Visualize and analyze internal structures in animal models or patients.
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
- Positron Emission Tomography (PET) Imaging Use PET imaging with radioactive agent to visualize and measure metabolic processes in the body.
Biomarkers
- Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Show all 20 in Biomarkers
- Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
- Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
- Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
- Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
- TUNEL Assay Detect in situ DNA fragmentation.
Show all 70 services
Cell Culture and Characterization
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Chemical and Compound Analysis
- Fluorescence Mediated Tomography Visualize the spatial distribution of fluorescencently labeled probes and substances.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Clinical Consulting
- Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Disease Models
- Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
- Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
- Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
- Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
Show all 10 in Disease Models
- Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
- Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
- Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
- Stroke Models Measure therapeutic endpoints in animal models of stroke.
DNA & RNA
- In Situ Hybridization Localize specific nucleic acid targets using labeled complementary probes.
- RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
- RNAscope In Situ Assays Profile single-cell gene expression in situ.
- Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Human Biological Samples
- HBS Alzheimer's Acquire fresh, frozen, or fixed Alzheimer's tissues or other related Alzheimer's HBS.
- Human TMA For requesting Human Tissue MicroArrays
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
- Human Custom TMA For requesting Human Custom Microarray Services
- Immunofocus™ Predict the response to anti PD1/PDL1 directed therapies.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Show all 7 in In Vitro Assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Target Characterization Characterize potential drug targets during the drug discovery process.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vivo ADME
- Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Oncology Models
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
- Oncology Xenografts Xenografts derived from oncological samples.
Safety Pharmacology
- Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
-
Sweden 3 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
. . Offspring Biosciences is provider of contract research services for advanced molecular pathology-based analyses About us Highly experienced team with solid skills from work as internal service providers at a major pharmaceutical company. We know what is required to deliver highly reliable and informative data for critical Stop-Go decisions in modern drug development. Scientific skills Our core competence is within research on inflammatory and neurological disorders (Alzheimer's and Parkinson's disease, Multiple sclerosis) and chronic pain states. However, our services and techniqual...
Show the full description
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Offspring Biosciences is provider of contract research services for advanced molecular pathology-based analyses
About us
- Highly experienced team with solid skills from work as internal service providers at a major pharmaceutical company. We know what is required to deliver highly reliable and informative data for critical Stop-Go decisions in modern drug development.
Scientific skills
- Our core competence is within research on inflammatory and neurological disorders (Alzheimer's and Parkinson's disease, Multiple sclerosis) and chronic pain states. However, our services and techniqual portfolio has wide applicability and we have also experience from working with projects targeting diabetes and cancer. Our team has recently been expanded with a scientist that brings solid experience from histopathological analyses supporting development of treatments for skin disorders.
Services
- Full study deliveries (design, execution and analysis)
- Target validation studies in tissues from pre-clinical disease models and in human tissues
- Profiling of SMD and biopharmceutical drug binding properties
- Quantitative evaluation of effect in pre-clinical treatment studies
- Supporting translational research activities
- Critical review of literature regarding quality, gap and risk analysis
- Expanded services via strategic collaborations (eg. in vivo pharmacology, evaluations by animal and human pathologists, bioanalysis, radiochemistry, whole body autoradiography, toxicological assessments
Techniques
- Chromogenic in situ hybridization histochemistry with unique performance (RNAScope)
- Robot-assisted immunohistochemistry analysis, up to 4x multiplexed IHC, ultra sensitive TSA detection and in situ PLA
- Cutting edge Quantitative Image Analysis based on stereology
- Aquisition and pathological evaluations of human tissues
- Efficient Tissue Processing, including generation and application of tissue microarrays
- Stringent QC of samples, thorough validation/calibration of bio-tools and lab equipment
- Histological stainings
- Digital whole slide image scanning
- Pathological assessments
- Website
- www.offspringbiosciences.com
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