Bicycle Therapeutics

Bicycle Therapeutics’ technology platform provides the unique ability to rapidly identify bicyclic peptides (bicycles) which have the potential to address targets not easily tractable with other modalities.

Bicycles have a structure that is much more highly constrained than monocycles or linear peptides, resulting in subnanomolar affinity. In addition the bicyclic structure results in a higher plasma stability.

The video below models the molecular dynamics of the same amino acid sequence as a linear peptide (left), as a monocycle (centre) and as a bicycle (right). The higher constraint of the bicycle results in the three side chains being more frequently in the correct orientation for binding to the target.