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GenScript

GenScript is listed as a large business research supplier in the Scientist.com network, with 14 sites in 5 countries and 3 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 14

Countries 5

Type of company: Large business

Antibodies

Affinity Maturation Use mutagenesis to optimize a complementary determining region and increase antibody affinity.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Isotype Switching Modify antibody isotypes from any species to any human IgG isotype.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.

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Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...
Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Hybridoma Production Produce monoclonal antibodies, involving mouse immunization, fusion, subcloning and antibody production.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
OmniRat Transgenic Animal Platform Produce humanized antibodies using a transgenic rat platform.
Pepscan Analysis Screen overlapping peptide sequences to identify linear epitopes.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Recombinant Antibody Production Request services related to antibody production services.
SARS-CoV-2 (COVID-19) Antibodies Search for available SARS-COV-2 antibodies
SARS-CoV-2 (COVID-19) Protein and Antigen Search for available SARS-CoV-2 proteins and antigens
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.
Yeast Display Discover or optimize eukaryotic proteins and antibodies that contain post translational modifications

Biomarkers

Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.

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Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.

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Cell Culture and Characterization

Bacterial Cell Culture Culture and Grow bacterial cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.

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Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.

Chemistry, Manufacturing and Controls (CMC)

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.

Consulting Network

Antibodies An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

Discovery Chemistry

Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.

Disease Models

Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Cough Models Test the therapeutic efficacy of drug candidates in cough models.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.

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Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.

DNA & RNA

Bacterial Plasmid Vector Create a transgene with an insert size of <10kb.
cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
cDNA library construction Generate a library of recombinant cDNA clones.
Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
DNA Amplification Amplify DNA from minimal concentrations of starting material.

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DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
DNA Reagents Request information or a price quote for DNA Reagents services
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
Plant siRNA Design Create selective and potent small interfering RNA constructs for plant gene analysis or crop improvement.
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
Polymerase Chain Reaction (PCR) Amplify a DNA sequence by PCR.
qPCR Analysis Measure the accumulation of PCR products in real time.
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.

In Vitro ADME

Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
SARS-CoV-2 (COVID-19) Assays Search for Available SARS-CoV-2 Assays

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Serine Protease Assay Detect apoptosis by measuring protease activity.

In Vitro Pharmacology

Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.

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In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
SELEX Select and identify highly specific aptamers with binding affinities comparable to traditional antibodies.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.

Non-Human Biospecimen

Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.

Oncology Models

Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Product Orders

BioTx General Biotherapeutics analyze therapeutics and drugs via biological means and recombinant DNA. Pre-clinical sample bioanalysis and le...
BioTx Reagents Biotherapeutic reagents are materials required for conducting therapeutics research. CROs provide reagents for antibody, DNA, p...
Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.

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Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
Lentivirus Production Develop lentiviruses and production protocols.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Native Protein Purification Purify native proteins from sources such as tissue & serum.
Neoantigen Development Develop neoantigens for oncological therapeutics for vaccine development.
NMR Determine molecular and protein structure, and validate sample integrity.
Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Phage Display Use in vitro screening method to identify protein binding partners.
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Reagents Request information or a price quote for Protein Reagents services
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.

Other services

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Service areas:

Biology Pharmacology Toxicology

United States Piscataway, Pennington, Redmond 8 sites
Netherlands 2288 EG, Leiden 2 sites
United Kingdom Oxford 2 sites
China Nanjing 1 site
Singapore Singapore 1 site

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GenScript is a leading biology CRO focusing exclusively on early drug discovery and development services. Built on their assembly-line mode, one-stop solution, continuous improvement, and stringent IP protection, GenScript provides a comprehensive portfolio of services that include Bio-Reagent, Bio-Assay, Lead Optimization, and Antibody Drug Development which can be effectively integrated into your value chain and your operations. Headquartered in New Jersey, USA, GenScript has over 800 employees, many of them are seasoned R&D scientists from leading western pharmaceutical and biotech companies with extensive experience in advancing drug discovery and development programs. They strive with competence and confidence to meet your demand for developing pre-clinical drug candidates time-efficiently and cost-effectively. With proven track record, GenScript is your ideal and reliable innovation partner in drug discovery.

Website: www.genscript.com

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