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Almac
Almac is listed as a large business research supplier in the Scientist.com network, with 5 sites in 2 countries and 2 service areas.
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Sites
5
Countries
2
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Antibodies
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Bioimaging
- Mass Spectrometry Imaging Visualize the spatial distribution of molecules, as biomarkers, metabolites, peptides or proteins by their molecular masses
Biomarkers
- Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Show all 9 in Biomarkers
- Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
- Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
- Whole Transcriptome Amplification Amplify total RNA from a single cell.
Chemical and Compound Analysis
- Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
- Chemical Stability Measure the stability of small molecules in solution.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- Compound Integrity Analyze the identity and purity of small molecule drug candidates.
- Denaturing High Performance Liquid Chromatography Separate mixtures of denatured and reannealed oligos to identify single nucleotide substitutions, deletions and insertions.
- Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Show all 19 in Chemical and Compound Analysis
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
- Ion Exchange Chromatography Separate and detect analytes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
- Photostability Measure drug degradation rates after exposure to various light sources.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- Spray Drying Convert a liquid into a powder by rapidly drying the mixture and removing the moisture component.
- Structural Chemistry Examine the relationship between protein structure and function.
Show all 86 services
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Compendial test methods Run Compendial test methods (e.g., KF)
- Drug product packaging and labeling Drug product packaging and labelling
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Show all 12 in Chemistry, Manufacturing and Controls (CMC)
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Powder Filling Use manual, automatic or semi-automatic machinery to package a variety of powder and granules.
- Product Insert Packaging Use product insert or leaflets to inform patients, satisfy regulatory requirements or extend a coupon offer.
- Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Clinical Trials
- Comparator Drug Sourcing Streamline new drug development and clinical trials by comparing the efficacy of an experimental drug to a comparator drug.
Companion Diagnostics
- Cervical Cancer CDx Design and validate companion diagnostics for cervical cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
- Osteoarthritis CDx Design and validate companion diagnostics for osteoarthritis that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
- Pancreatic Cancer CDx Design and validate companion diagnostics for pancreatic cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
- Rheumatoid Arthritis (RA) CDx Design and validate companion diagnostics for RA that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Discovery Chemistry
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
- Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
- USP Testing Analytical Reagents Acquire chemical reagents, solution concentrates and volumetric solutions used to evaluate items in USP testing.
DNA & RNA
- Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
- De Novo Transcriptome Sequencing Identify new genes without the need for a reference genome sequence.
- Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
- miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
- Nanostring nCounter Use single molecule imaging to count molecules directly and without enzymatic amplification.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Show all 13 in DNA & RNA
- RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
- RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- RNAscope In Situ Assays Profile single-cell gene expression in situ.
- Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
- Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Human Biological Samples
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
In Vitro ADME
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
In Vitro Pharmacology
- Protease Assay Measure protease activity in biochemical and cell-based assays.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Market Access
- Marketing and Commercialization Identify, promote and prove the value of a particular drug to key stakeholders.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- PEG Protein Conjugation Improve the therapeutic or pharmacokinetic properties of a protein by pegylation.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Protein Purification Isolate native or recombinant proteins from a sample.
Scientific Data Services
- Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
- Marker Analyses Identify associations between genetic markers and traits of interest to determine markers responsible for human diseases.
- Metabolomics Data Analysis Use metabolites to identify any potential biomarkers or novel therapeutic targets that may play a role in the mechanisms responsible for the progression of a disease.
- Omics Informatics Consulting Services for the analysis of large-scale molecular data sets.
- Small RNA Gene Expression Quantify and analyze miRNA, piRNA, siRNA as well as other small nuclear RNAs from small-RNA-seq raw input data sets.
Testing Services
- Characteristic Testing Characterization of physical and chemical properties of raw materials
- Raw Material Microbiological Testing Examples of which include Microbial Content using USP <61> and <62> and other standards, LAL Endotoxin, Ames Mutagenicity and Sterility.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Other services
- New Request
Service areas:
Biology
Chemistry
Where it operates
Sites by country, with the cities in each.
-
United Kingdom 3 sites
-
United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Almac offers scaffold synthesis, API supplies, solid state chemistry, clinical/commercial manufacturing, and process optimization.
- Website
- www.almacgroup.com
Work with Almac on Scientist.com
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