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Research supplier
BioFocus
BioFocus is listed as a mid sized business research supplier in the Scientist.com network, with 4 sites in 3 countries and 4 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Biomarkers
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Chemical and Compound Analysis
- Co Crystallization Co-crystallize drug candidates and target proteins for use in x-ray diffraction studies.
Chemistry, Manufacturing and Controls (CMC)
- Formulation Development Optimize bioavailability, stability, salt forms, plasma stability and excipient release in vivo.
In Vitro Assays
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Microbiology Study microbes and their role in human health.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Protein Sciences
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Service areas:
Where it operates
Sites by country, with the cities in each.
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United Kingdom 2 sites
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Switzerland 1 site
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
BioFocus aims to expand its partners’ drug pipelines by accelerating the gene-to-drug candidate discovery process. This is achieved through a comprehensive discovery platform, which includes target discovery in human primary cells, focused as well as diverse compound libraries, _in vitro _and cell-based screening, structural biology, medicinal chemistry, ADME/PK services, supported by unique chemogenomic and informatics tools, and compound library acquisition, storage and distribution services. As a service division of Galapagos, BioFocus has over 250 employees in three countries worldwide...
Show the full description
BioFocus aims to expand its partners’ drug pipelines by accelerating the gene-to-drug candidate discovery process. This is achieved through a comprehensive discovery platform, which includes target discovery in human primary cells, focused as well as diverse compound libraries, _in vitro _and cell-based screening, structural biology, medicinal chemistry, ADME/PK services, supported by unique chemogenomic and informatics tools, and compound library acquisition, storage and distribution services. As a service division of Galapagos, BioFocus has over 250 employees in three countries worldwide.
We provide services in:
- Permeability: PAMPA, Bi-directional Caco-2
- Stability: Hepatocyte, microsomal, aqueous, plasma
- High Content Screening: apoptosis, motility, epigenetic, imaging
- ADME: protein binding, equilibrium dialysis, PK
- Structural Biology: protein production, x-ray crystallography
As of March 31, BioFocus has been acquired by Charles River Laboratories
- Website
- www.biofocus.com
Work with BioFocus on Scientist.com
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