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Symeres
Symeres is listed as a mid sized business research supplier in the Scientist.com network, with 6 sites in 4 countries and 1 service area.
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Sites
6
Countries
4
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Compound Integrity Analyze the identity and purity of small molecule drug candidates.
- Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Discovery Chemistry
- Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
Show all 12 in Discovery Chemistry
- HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
- Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
- Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Show all 46 services
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
Show all 19 in In Vitro ADME
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
- Reference Standards Find reference standards for assays, tests and services.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- New Request
Service areas:
Chemistry
Where it operates
Sites by country, with the cities in each.
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Netherlands 3 sites
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Czechia 1 site
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Finland 1 site
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Mercachem provides a range of chemical services, from exclusive synthetic and process chemistry services to support research and development services.
- Website
- www.symeres.com
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