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Eurofins Discovery

Eurofins Discovery is listed as a large business research supplier in the Scientist.com network, with 13 sites in 6 countries and 4 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 13

Countries 6

Type of company: Large business

Agricultural Sciences Research & Development

Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.

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Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
OmniRat Transgenic Animal Platform Produce humanized antibodies using a transgenic rat platform.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Recombinant Antibody Production Request services related to antibody production services.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.

Bioimaging

Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Thermal and Acoustic Imaging Measure the dielectric and optical properties of biological tissues corresponding to pathological states.

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Biomarkers

Autoantibody Testing Screen for the presence of an autoimmune disorder.
Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body

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Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Peptide Bioanalysis Analyze the structure of Peptides.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Protein Glycosylation Mapping Technique Map glycosylation sites in proteins using liquid chromatography and mass spectrometry.
TUNEL Assay Detect in situ DNA fragmentation.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

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Endotoxin Characterization Identify specific molecular structure (e.g., Lipid A profiling), determine bacterial source/strain, and assess biological potency of endotoxins
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.

Chemical and Compound Analysis

Adsorption/Desorption Studies Obtain data on groundwater risk assessment.
Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Chemical Stability Measure the stability of small molecules in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.

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Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Ion Exchange Chromatography Separate and detect analytes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
Nano-High Performance Liquid Chromatography Separate and detect low levels of analytes.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Photostability Measure drug degradation rates after exposure to various light sources.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structural Chemistry Examine the relationship between protein structure and function.

Chemical and Compound Testing

USP <2021> Microbial Enumeration Tests Estimate the total aerobic microbial count, total combined yeast and mold counts, and the presence of bile-tolerant gram-negative bacteria present in nutritional supplements.

Chemistry, Manufacturing and Controls (CMC)

Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.

Clinical Consulting

Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Product Testing Consulting Expert advice to evaluate the effectiveness, quality, and legitimacy of a given item or good.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Data Science/Bioinformatics

Discovery In Silico Proteome Analysis Used to understand the global protein environment, specifically drug-protein interactions.

Developmental and Reproductive Toxicology (DART)

Embryo-Fetal Development (EFD) Study (Segment II) Test drug candidate in Segment II toxicology services.
Fertility and Embryonic Development Study (Segment I) Test drug candidate in Segment I toxicology services.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.

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Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Natural Product Screening Screen large natural product collections for therapeutic activity.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Time of Flight Mass Cytometry (CyTOF™) Detect and quantify up to 34 different proteins simultaneously on a single-cell level.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Auto-immune Hepatitis Models Measure therapeutic endpoints in animal models with auto-immune hepatitis.

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Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cough Models Test the therapeutic efficacy of drug candidates in cough models.
Critical Care Models Diagnose and manage life-threatening conditions requiring sophisticated organ support and invasive monitoring.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
Emesis Models Measure therapeutic endpoints in animal models of emesis.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.
Hepatitis C Virus Models Measure therapeutic endpoints in animal models of Hepatitis C virus infection.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Influenza Models Measure therapeutic endpoints in animal models of influenza.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Malaria Models Measure therapeutic endpoints in animal models of malaria.
Microsurgery in Rodents Outsource microsurgeries projects required for testing new therapies on a rodent model.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Sepsis Models Measure therapeutic endpoints in animal models of sepsis.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Extraction Isolate total RNA or mRNA from cells or tissues

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RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.
Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

Food Safety & Regulations

Carbohydrate Testing Determine the types and concentrations of carbohydrates in foods for nutritional labeling, quality control, and for identifying possible adulteration.
Methylmercury Analysis Ensure methylmercury concentration in products is below the maximum allowable limits for consumer safety.

General in vivo Toxicology

Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human 3D cultures Provision of 3D culture of Human Primary Cells
Human Buffy Coats Acquire fresh/frozen Buffy Coats based on patient demographics, disease stage, treatment and history.
Human Cell Lysates For requesting human Cell lysates.
Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...

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Human Leukopaks Obtain enriched leukapheresis-derived products from normal peripheral blood.
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Plasma Acquire fresh/frozen human plasma
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
Human Serum Acquire fresh/frozen normal serum based on patient demographics and history.
Human Whole Blood For requesting Human Whole Blood

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.

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CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.

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Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
Glucose Release Assay Determine free glucose levels in biological samples.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
SARS-CoV-2 (COVID-19) Assays Search for Available SARS-CoV-2 Assays
Serine Protease Assay Detect apoptosis by measuring protease activity.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.

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Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
Human BCL Assays Use biochemical, cell-based or in vivo assays to measure BCL activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Cytotoxicity Test for effects on cell viability and proliferation

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Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Microelectrode Array Cardiotoxicity Assays Use microelectrode array to measure cardiotoxicity-related activities.
Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

Cardiac Safety Assessment Assess cardiotoxicity using microelectrode assay technology.
In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.

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Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Fresh Functional Human Tissue Ion Channel Activity Assays Use fresh functional human tissue to assess ion channel activity with various compounds.
Fresh Functional Human Tissue Vascular Permeability Assays Use fresh functional human tissue to assess vascular permeability with various compounds.
Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.

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Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Non-Human Biospecimen

Dog / Canine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Pig / Minipig / Porcine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Rat Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.

Oncology Models

Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
Reproductive System Xenografts Xenografts relating and derived from the reproductive systems. This includes samples from the ovaries, cervix, vulva, uterus, testes, scrotum, and prostate.

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Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Phototoxicity Determine whether drug treatment causes light-activated toxic effects.

Product Development

Personal/Consumer Care Product or Service Request relating to the creation, testing or manufacturing of a personal care/consumer health/cosmetic product, ingredient or raw material.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.

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Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Native Protein Purification Purify native proteins from sources such as tissue & serum.
PEG Protein Conjugation Improve the therapeutic or pharmacokinetic properties of a protein by pegylation.
Peptide Discovery Identifying and developing new peptides.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Phage Display Use in vitro screening method to identify protein binding partners.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein mapping Interrogate the entire sequence of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

REACH Services

Hazard, Exposure and Risk Assessment Evaluate the known hazard of a test compound in conjunction with the expected quantity and frequency of exposure.
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Real World Evidence & Data

RWD - Genomics Genomic data collected from a patients with different diseases, can be derived from a range of sources.

Safety Pharmacology

Abuse and Dependence Liability Testing Determine the abuse or dependence potential of a therapeutic.
Abuse Liability Determine the dependence potential of a therapeutic.
Endocrine Disruptor Screening Use biochemical, cell based or in vivo assays to identify and quantify endocrine-modulating agents.
Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

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Safety Screen Panel Assays Safety Pharmacology safety screen panel assays enable early identification of significant off-target interactions with your compound(s)
Seizure Liability Study - Other Species Conduct a study to determine the seizure risk of your compound in other species.
Seizure Liability Study - Rat Conduct a study to determine the seizure risk of your compound in rats.
Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.
Telemetry Use implantable or external devices to study physiological parameters in model organisms

Scientific Data Services

Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
Marker Analyses Identify associations between genetic markers and traits of interest to determine markers responsible for human diseases.
Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
Pharmaco-genomics Genetic polymorphism contribution to inter-individual variability in drugs' responses and/or adverse events.

Target Animal and Human Food Safety

Target Animal Safety (TAS) Studies Evaluate potential harmful effects associated with the use of a new animal drug in a controlled setting.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Skin Lightening Product Test Measure qualitative and quantitative changes in skin pigmentation under the influence of the test sample.

Other services

Biological Material For requesting cells and other propagatable material.
BioMAP® Human Phenotypic Cell-based Platform Use BioMAP® systems for lead selection and optimization, mechanism of action identification, and secondary and off-target activities.
New Request  
Qube - High Throughput Screening Screen large compound libraries for ion channel blockers and modulators.

Service areas:

Biology DMPK Pharmacology Toxicology

United States Fremont, San Diego, St Charles 5 sites
France Celle L'Evescault, Celle-L'Evescault, Lyon 3 sites
Taiwan New Taipei City 2 sites
India Hyderabad 1 site
Spain Fuente Álamo de Murcia 1 site

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Eurofins Cerep-Panlabs (Eurofins Pharma Discovery Services) was established in March 2013 as a result of the merger of Eurofins Panlabs and Eurofins Cerep, two leaders in drug discovery services. The merge provides a portfolio of hundreds of both in vitro and in vivo assays, offering the largest available pharmacological panel for drug screening and profiling.We set the benchmarks for quality, convenience, and expertise and are the most experienced pharmacology service company in continuous operation for over 40 years. The merger of both entities enhances valuable existing expertise...

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The merger of both entities enhances valuable existing expertise, knowledge and skills. Moreover, with over 350 people in four operational sites worldwide: Poitiers (France); Seattle, WA (USA); Shanghai (China) and Taipei (Taiwan), Eurofins Cerep-Panlabs offers logistics and functional solutions to perform studies with the highest quality to meet customer needs.

From conventional binding assays, to cellular disease models (oncology and immunology, in vitro toxicology) or the highly valued epigenetic targets, Eurofins Cerep-Panlabs covers complete customer requirements in all therapeutic area. The offer includes high throughput profiling and screening services as well as customized assay development.

In Vitro Pharmacology Profiling

Our In Vitro Pharmacology profiling/screening services cover a wide range of target classes including different receptors, GPCRs, various enzymes, transporters and ion channels and employ methods and assay types such as radioligand binding assays, calcium mobilization and cAMP measurement using TR-FRET, transporter/uptake assays, and bioluminescent and other fluorescent-based assays.

Receptors binding assays (GPCRs, nuclear receptors, growth factor and other transmembrane receptors)
Ion Channels (Ca2+, K+, Na+) and ligand-Gated Ion Channels (Glutamate, GABAA, 5-HT3)
Transporters (Adenosine, Choline, GABA, NE, DA, SERT)
Kinases (serine/threonine, tyrosine etc.)
Epigenetic & DNA-related enzymes and other enzymes
Specialized cellular assays (cell adhesion, cell migration, cell proliferation and cell viability etc.)
Foresight™ and BioPrint®, two proprietary databases to predict in vivo activity from in vitro data and anticipate adverse drug reactions at early stage

In Vivo Assays

We offer relevant in vivo screening models to evaluate the pharmacological effects of drug candidates in all major therapeutic categories, with an emphasis on Anti-infectives, Inflammation/Allergy, CNS disorders, and Oncology. We provide therapeutically focused disease models, incorporating the biomarkers and outcome measures that enable greater prediction of clinical success.

Anti-Infective
Cardiovascular
Central Nervous System
Gastrointestinal
Inflammation/Allergy
Metabolic/Endocrine
Oncology
Pain
Respiratory
Safety

Cellular Assays

We provide cell based assay services in Oncology, Immunology, and Functional Toxicology. These assays utilize primary human cells, as well as cancer cell lines, to generate quality data which enable the scientist to make educated decisions on efficacy, off target toxicity potential, relevant biomarkers of sensitivity, and resistance for their compounds.

Oncology: OncoPanel™ 240 provides multiparametric drug response data of a small molecule or biologics across a panel of genomically diverse cancer cell lines spanning all general cancer types.
Immunology: ImmunoSignal™provides validated cellular models to measure cytokines, chemokines and other secreted proteins.
Functional Toxicology: Functional toxicity assays utilize multiple cell types, including human liver cells, renal cells, dermal cells, stem cells, and other mammalian cells, to provide sensitive in vitro cell-based genetic and organ-specific toxicity testing.

ADME-Toxicity & Pharmacokinetics (PK)

Our ADME-Tox & PK services include in vitro ADME, in vitro toxicity and in vivo PK with over 240 assays for rapid evaluation of pharmaceutical properties and safety of drug compounds:

In Vitro ADME: screen compounds for Absorption, Distribution, Metabolism and Excretion properties through in vitro assays by using detection methods of LC-MS, LC-UV and plate readers (fluorescence, nephelometry)
In Vitro Toxicity: screen compounds for potential toxicity in the area of cardiac toxicity, cytotoxicity and Genetic toxicity by using technologies of automated and manual patch-clamp, HCA, UV and fluorescence plate readers
In Vivo PK: screen compounds for PK properties through in vivo models in rodents (mice and rats). In addition, we have also developed in vivo blood-brain barrier assays in rats and mice to evaluate the brain penetration of compounds.

Website: www.eurofinsdiscovery.com

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