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Metabolon, Inc.

Metabolon, Inc. is listed as a mid sized business research supplier in the Scientist.com network, with 3 sites in 2 countries and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 3

Countries 2

Type of company: Mid sized business

Agricultural Sciences Compliance and Quality Control Measures

Ecological Toxicity testing for terrestrial and aquatic animals and plants.
Endocrine Screening Screening to determine risk due to disruption of the endocrine system.
Exposure Tests which assess human health impact upon exposure of product.
GMO Seed Testing Evaluate whether or not a seed has been genetically altered from its native state.
National Pollutant Discharge Elimination System Analyze tests according to permits issued by the National Pollutant Discharge Elimination System permitting authority.
Pesticide Product Testing Use laboratory assays to evaluate the efficacy, safety and selectivity of a pesticide under GLP standards.

Show all 12 in Agricultural Sciences Compliance and Quality Control Measures 6 more

Product Performance Antimicrobial efficacy and invertebrate control agent testing.
Product Properties Determination of physical and chemical properties of product
Production and Preservation Assistance with the transfer of primary products to end consumer.
Residue Chemistry Pesticide residue and tolerance testing.
Seed Genetic Purity Test (Non-Hybrid) Utilize sensitive and robust methods to evaluate the genetic purity of non-hybrid seed lots.
Whole Effluent Toxicity Methods Perform Whole Effluent Toxicity tests to determine toxicity of wastewater effluent.

Agricultural Sciences Research & Development

Agro-product Storage Stability Testing Monitor agro-product changes over time to optimize packaging, storage conditions and product longevity.
Agrochemical Analytical Method Development Engineer sensitive and selective methods that meet GLP validation requirements to assess different agrochemical properties.
Agrochemical Identification Product identification and composition of pesticides; which includes fungicides, insecticide, herbicides and nematicides analysis.
Agrochemical Physio-Chemical Testing Conduct extensive property characterization of agrochemicals for geo-specific product approval and registration.
Animal Feed Supplements Test for mineral nutrients and medicinal compounds for the prevention or control of disease.
Biofortification Efficacy and effectiveness studies in the enhancement of nutrients in plants

Show all 17 in Agricultural Sciences Research & Development 11 more

Chemical and Physical Determination of chemical and physical properties of pesticide product.
Crop and Seed Genetic Engineering Genetics screens using microarrays, transcriptomics, or gene sequencing to find the best genes to be selected for improved crop varieties.
General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.
GMO and GE Viability Measure the viability and germination rate of genetically engineered organisms
Hormone & Soil Conditioning Agents Detection of emerging chemicals of concern.
Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties
Molecular Markers Use of molecular diagnostics to analyze biological markers in the genome and proteome.
Pesticide Conduct field trials to determine environmental risk assessment and associated studies pertaining to residue, efficacy, soil dissipation and the like.
Qo Inhibitors (Quinone Outside Inhibitors) Determine anti-fungal activity against a wide range of fungal diseases.
Soil Science Test for microbial inoculants that promote plant health
Synthetic Fertilizers Determination of heavy metals and other toxic compounds in addition to composition.

Show all 193 services 181 more

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Autoantibody Testing Screen for the presence of an autoimmune disorder.
Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.

Show all 33 in Biomarkers 27 more

Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Bone Resorption Assay Functionally analyze osteoclast activity in vitro.
Cell Membrane Lipidomics Study the pathways and networks of membrane lipids.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Lipoprotein Associated Phospholipase A2 Testing Assess vascular inflammation and determine the risk for atherosclerosis or arterial plaque rupturing.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Microfluidics-Based Biomarker Isolation and Detection Isolate and detect rare biomarkers in blood samples, such as CTCs, cfDNA, and exosomes.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Myeloperoxidase Testing Detect inflammatory markers and determine the risk for atherosclerosis or arterial plaque rupturing.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Cell Culture and Characterization

Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.
Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Spent Media Analysis Measure chemical alterations, such as variations in amino acids, glucose, contaminants, and metabolites, in a cell culture medium throughout the culturing process.

Chemical and Compound Analysis

Chemical Stability Measure the stability of small molecules in solution.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Show all 7 in Chemical and Compound Analysis 1 more

Sample Bioanalysis Determination of concentration of an analyte in biological sample.

Chemical and Compound Testing

Bacterial Water Analysis Analyzing water samples to identify the bacteria present.
Limulus Amebocyte Lysate (LAL) Test Detect bacterial endotoxins in raw materials used for the production of cosmetics products.
USP <2021> Microbial Enumeration Tests Estimate the total aerobic microbial count, total combined yeast and mold counts, and the presence of bile-tolerant gram-negative bacteria present in nutritional supplements.
USP <2022> Microbiological Procedures for Absence of Specified Microorganisms Determine the absence of objectionable organisms in nutritional supplements.
USP <85> Bacterial Endotoxin Test Test to detect or quantify bacterial endotoxins that may be present in or on a sample.

Chemistry, Manufacturing and Controls (CMC)

API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Compendial test methods Run Compendial test methods (e.g., KF)

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.

Data Science/Bioinformatics

Clinical Biomarker Analysis An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Discovery Biomarker Analytics An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.

Discovery Chemistry

LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.

Disease Models

Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Microbiome-Based Skin Disease Technology Modify the skin microbiome and deliver therapeutic proteins to the target.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Pharmacogenetics Consulting Access genomic services required for clinical trials, such as genotyping, genetic variation testing and DNA isolation.
Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.

Drug Metabolism and Pharmacokinetics (DMPK)

Biomarkers DMPK Biomarker DMPK and gene analysis services are critical tools in evaluating patients and discovery of new therapeutics.

Farm & Livestock Solutions

Animal Feed Analysis Test the content and quality of nutrients and biologically active substances in animal feeds. Some analysis that is conducted on feed include; dry matter, crude ash, ash insoluble in acid (sand), crude protein, crude...
Herd Productivity Improving reproductive efficiency, productions yields, maintenance of healthy animals by routine biosecurity screening and testing.
Phosphorus Buffering Index Assess the ability of soil to bind phosphorus to predict availability for plant uptake.
Soil Alkalinity Testing Determine soil alkalinity to assess plant suitability or amend soil pH.
Soil Environmental Testing Measure environmental contaminants using soil sample analysis.
Soil Fertility Testing Evaluate soil growth potential based on nutrient deficiencies or toxicities.

Show all 9 in Farm & Livestock Solutions 3 more

Soil Testing Use various tests to characterize a soil sample.
Viral Molecular Diagnostic Determination of genetic markers for virus identification. Detect common infectious agents and foreign animal diseases that may threaten animal or human health.
Virology Virus isolation for identification of new and emerging viruses.

Human Biological Samples

Human Exosomes Request services related to the creation and development of human exosomes

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.

Show all 28 in In Vitro ADME 22 more

Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
Human Blood Brain Barrier on a Chip (BBBoC) Create a blood–brain barrier multicellular model to test drug delivery to the brain.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Reference Standards Find reference standards for assays, tests and services.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Pathogen Assays Detect and distinguish viral, bacteria and fungal strains and species.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

In Vitro Pharmacology

High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
Target Identification Identify the target(s) of a biologically active substance.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine Conduct a bile duct cannulation (BDC) study in dogs/canines to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Monkey / Non-human Primate Conduct a bile duct cannulation (BDC) study in monkeys/non-human primates to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Other Species Conduct a bile duct cannulation (BDC) study in other species to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
In Vivo Radiolabeled Metabolism Determine the qualitative and quantitative metabolism and/or degradation of an active ingredient in animals.

Show all 22 in In Vivo ADME 16 more

Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Minipig Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in minipigs.
Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Mass Balance Study - Other Species Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in other species.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Milk Secretion Study - Other Species Conduct a study to determine the extent of milk secretion of your radioactive compound in other species.
Milk Secretion Study - Rat Conduct a study to determine the extent of milk secretion of your radioactive compound in rats.
Ocular Distribution Study - Dog / Canine Conduct a study to determine the distribution of your compound in ocular tissues of the dog/canine.
Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Ocular Distribution Study - Other Species Conduct a study to determine the distribution of your compound in ocular tissues of other species.
Ocular Distribution Study - Rabbit Conduct a study to determine the distribution of your compound in ocular tissues of the rabbit.
Ocular Distribution Study - Rat Conduct a study to determine the distribution of your compound in ocular tissues of the rat.
Placental Transfer Study - Other Species Conduct a study to determine the extent of placental transfer in other species by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Placental Transfer Study - Rabbit Conduct a study to determine the extent of placental transfer in rabbits by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Placental Transfer Study - Rat Conduct a study to determine the extent of placental transfer in rats by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Show all 16 in In Vivo Pharmacokinetics 10 more

Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Protein Sciences

LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.

Radioanalysis

Stand-alone Radioanalysis of Animal Pre-clinical Samples Conduct analysis of radioactive samples from preclinical radiolabeled studies.

REACH Services

Acute Toxicity Study - Parasitic Wasps (Aphidius rhopalosiphi) This study is designed to estimate the acute toxicity of substances to Parasitic Wasps (Aphidius rhopalosiphi), including an option for reproductive toxicity.
Acute Toxicity Study - Soil Mites This study is designed to estimate the acute toxicity of substances to Soil Mites, including an option for reproductive toxicity.

Real World Evidence & Data

Clinical Phenotype Data Obtain phenotypic data and observations on patients such as the clinical manifestation of the disease, clinical and behavioral parameters, symptoms, and laboratory test results.

Safety Pharmacology

Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

Scientific Data Services

Marker Analyses Identify associations between genetic markers and traits of interest to determine markers responsible for human diseases.
Metabolomics Data Analysis Use metabolites to identify any potential biomarkers or novel therapeutic targets that may play a role in the mechanisms responsible for the progression of a disease.
Microbiome Data Analysis Determine the population composition of a microbial community and analyze its contribution to human or animal health.

Testing Services

Microbiological Sterility Testing Test the presence of viable microorganisms.
USP <61> Microbial Limits Test Determine whether a substance or preparation complies with an established specification for microbiological quality.
USP <62> Microbial Limits Test Determine the presence or absence of specific microorganisms.

Other services

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Service areas:

Biology Chemistry

United States Morrisville 2 sites
Germany Hallbergmoos 1 site

Metabolon is a metabalomics service provider offering global metabolism analysis including primary and secondary metabolism and complex lipid analysis. Our patented platform provides a global analysis of complex biological samples for the discovery of markers and pathways associated with drug action and disease. This differentiated approach enables the identification of biomarkers useful for the development of a wide range of diagnostics and provides insight into complex biochemical processes such as drug action, toxicology and bioprocess optimization. Metabolon’s fee-for-service business...

Show the full description

Metabolon’s fee-for-service business is focused on product-based global biochemical profiling solutions provided to pharmaceutical and biotechnology companies as well as funded government and academic institutions engaged in product development activities.
We provide comprehensive biochemical profiling for a wide variety of applications, including drug safety and efficacy studies, bioprocess optimization and consumer product development. We are currently working with 14 of the top 15 pharmaceutical companies and many biotechnology companies.

Professional associations: AAPS, American Association for Cell Biology, American Society for Biochemistry and Molecular Biology (ASBMB)
Website: www.metabolon.com

Minority-owned

US small-business federal-contractor designation, self-certified in the U.S. federal System for Award Management (SAM.gov). Coverage is limited to matched U.S. small-business suppliers, so an absent designation is not evidence of its absence.

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