Organovo

Organovo is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

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Countries 1

Logo Organovo, via Wikimedia Commons, Public domain. Shown to identify the organization; it may be a registered trademark.

Type of company: Small business

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.

Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.

Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
HBS NASH For requesting HBS NASH
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...

Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.

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Cytotoxicity Test for effects on cell viability and proliferation
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

Organotypic Small Intestinal Tissue Model Use a 3D co-culture model of human intestine for drug toxicity, permeability, drug-drug interaction and metabolism studies.

Service areas:

Biology Equipment

Organovo offers three-dimensional bioprinting technology to design and create functional human tissues.

Work with Organovo on Scientist.com

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