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Marin Biologic Laboratories
Marin Biologic Laboratories is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 2 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody Detection Quantitate, localize and visualize proteins and other antigens.
- Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
- Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
- Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Biomarkers
- Autoantibody Testing Screen for the presence of an autoimmune disorder.
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
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- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
- Osteoclasts Measure osteoclast activity and bone resorption in human, mouse or rat assays.
Cell Culture and Characterization
- Cell Culture Culture primary or immortalized cell lines.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
- Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Show all 69 services
Chemical and Compound Analysis
- Ion Exchange Chromatography Separate and detect analytes.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Discovery Chemistry
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
DNA & RNA
- qPCR Analysis Measure the accumulation of PCR products in real time.
- RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
Human Biological Samples
- Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- Human Bone Marrow Cells Acquire fresh, frozen, or fixed normal bone marrow based on patient demographics and history.
- Human Whole Blood Acquire fresh/frozen normal whole blood based on patient demographics and history.
In Vitro ADME
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
- Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Show all 12 in In Vitro Assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
- Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
- Serine Protease Assay Detect apoptosis by measuring protease activity.
- Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.
In Vitro Pharmacology
- Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
- Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
Show all 10 in In Vitro Pharmacology
- Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
- Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
- Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Cytotoxicity Test for effects on cell viability and proliferation
- Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
- Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
- Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Native Protein Purification Purify native proteins from sources such as tissue & serum.
- Protein Binding Determine drug-protein binding interactions
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein Services Protein analysis and tagging are key steps in understanding the effects of compounds and treatments on your target disease outc...
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Other services
- Cell Arrays Build, use and analyze cell-based and cell-lysate-based microarrays.
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
p<>. Marin Biologic Laboratories provides solutions in protein analytical and biological assays and other services for our many clients. Marin Biologic develops, validates, and performs a variety of assays for lot release potency, PK and PD studies, host antibody (Anti-Drug Antibodies), bioassays for drug bioactivity, and humoral and cellular immunity assays. We also offer molecular biology services, and protein production, purification and analysis. Marin Biologic Laboratories is FDA inspected and can perform these tests with or without GLP/GMP conditions. We would like to help meet your...
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p<>. Marin Biologic Laboratories provides solutions in protein analytical and biological assays and other services for our many clients. Marin Biologic develops, validates, and performs a variety of assays for lot release potency, PK and PD studies, host antibody (Anti-Drug Antibodies), bioassays for drug bioactivity, and humoral and cellular immunity assays. We also offer molecular biology services, and protein production, purification and analysis. Marin Biologic Laboratories is FDA inspected and can perform these tests with or without GLP/GMP conditions. We would like to help meet your requirements in a timely and cost effective way.
p<>. Marin Biologic Laboratories is a contract laboratory for pharmaceutical and biotech industries. We have been operating for 16 years and we take pride in our science as well as the quality of our communication. We specialize in development and validation of cell based assays and immunoassays as well as enzyme assays, protein and RNA expression, transfections, protein purification, and radioactivity methods.
p<>. We have developed and performed a variety of human and murine cellular immunology assays ex vivo, macrophage/monocyte activation, lymphocyte proliferation and cytokine production and cell surface markers (FACS analysis), NK, ADCC, cytotoxic T lymphocyte (CTL), complement killing, etc. Our niche is to take projects encompassing several fields such as biochemistry, molecular and cell biology and bring them to a rapid and successful conclusion. Companies with seemingly intractable problems of imprecision in bioassays, detecting low levels of protein analytes, or interference by blood and other biological matrices have turned to us for solutions.
p<>. Our staff has developed and validated ELISA and bioassays for numerous Ab projects, plus some related candidates (Fab, Fab2, PEG conjugates). This included potency assays for drug (ELISA at IND, bio at Phase III), for PK in animals and humans, host antibodies to the product, free vs bound drug in plasma, endogenous plasma target proteins, tox/PD/efficacy markers, etc. Marin Biologic has developed, qualified, validated, run or transferred over 50 ELISA and bioassays in the past 3 years, some were GLP or GMP.
p<>. So that we may be prompt in our communication, please include Dr. Tania Weiss, our President and CEO, [removed], and Scott Rosenberg, Administrative Assistant, [removed], on your emails.
Peter Ralph, Ph.D.
VP Science and Technology
Marin Biologic Laboratories, Inc.
378 Bel Marin Keys Blvd.
Novato, CA 94949
Phone [removed]
FAX [removed]
www.marinbio.com
- Professional associations
- BayBio
- Website
- www.marinbio.com
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