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Aragen

Aragen is listed as a large business research supplier in the Scientist.com network, with 10 sites in 2 countries and 4 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 10

Countries 2

Type of company: Large business

Agricultural Sciences Research & Development

Agro-product Storage Stability Testing Monitor agro-product changes over time to optimize packaging, storage conditions and product longevity.
Agrochemical Analytical Method Development Engineer sensitive and selective methods that meet GLP validation requirements to assess different agrochemical properties.
Agrochemical Physio-Chemical Testing Conduct extensive property characterization of agrochemicals for geo-specific product approval and registration.
General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...

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Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.

Biomarkers

Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.

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Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Show all 207 services 191 more

Cell Culture and Characterization

Bacterial Cell Culture Culture and Grow bacterial cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Services Most drug research projects routinely use a variety of cell research services including cell line construction, analysis of cells.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

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Insect Tissue Culture Grow insect cells.

Chemical and Compound Analysis

API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Ion Exchange Chromatography Separate and detect analytes.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.

Show all 14 in Chemical and Compound Analysis 8 more

NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structural Chemistry Examine the relationship between protein structure and function.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemistry, Manufacturing and Controls (CMC)

API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Bulk Manufacturing Find facilities for large-scale mass production.
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services

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Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.

Discovery Chemistry

Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.

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Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.

Disease Models

Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
General Pain Models Measure therapeutic endpoints in animal models of general pain.

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Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
Malaria Models Measure therapeutic endpoints in animal models of malaria.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
DNA Library Creation Construct cDNA, plasmid and genomic DNA libraries.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...

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Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.

General in vivo Toxicology

Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.

Human Biological Samples

Master Cell Banking Characterize, expand, cryopreserve, store and track cell samples.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).

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CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Fully Automated Assays Develop and perform assays that require no manual steps
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.

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High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Pathogen Assays Detect and distinguish viral, bacteria and fungal strains and species.

In Vitro Pharmacology

Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.

Show all 15 in In Vitro Pharmacology 9 more

In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Reversibility Study Determine whether or not a compound inhibits an enzyme reversibly.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Test for effects on cell viability and proliferation

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Disease Model Database For sourcing disease models.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Product Orders

BioTx General Biotherapeutics analyze therapeutics and drugs via biological means and recombinant DNA. Pre-clinical sample bioanalysis and le...
Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Cytokines Find recombinant cytokines or cytokine assays.
Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.

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Protein Binding Determine drug-protein binding interactions
Protein Engineering Alter the features or properties of a protein for a specific purpose.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

REACH Services

In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests

Safety Pharmacology

Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
PAO Stability Trial Assess the stability of a consumer product under certain storage conditions.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Other services

New Request  
RNA Isolation Purify RNA from pre-clinical and clinical samples.

Service areas:

Biology DMPK Pharmacology Toxicology

India Nacharam, Hyderabad, Bengaluru, Hyderabad, Pune, Visakhapatnam 8 sites
United States Morgan Hill 2 sites

Aragen Bioscience offers cell line development, protein expression and purification, molecular biology, cell biology immunology, and diverse in vivo services to the biotech and pharmaceutical industries. Our corporate offices and in vitro laboratories are located in Morgan Hill, California at the south end of Silicon Valley. Aragen and its predecessor, Sierra BioSource, have been operating in the San Francisco Bay Area since 1993. The research experts at Aragen Bioscience have extensive industrial biotechnology experience for your application. Aragen Bioscience offers a full range of custom...

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The research experts at Aragen Bioscience have extensive industrial biotechnology experience for your application. Aragen Bioscience offers a full range of custom research services from routine to complex.

Each of these services can be applied to the research, optimization and development phase of a project. Aragen Bioscience services are highly collaborative, well-documented and timely; giving you control over the entire process. Our customer dedicated research teams ensure your project gets the attention and focus that will lead to success.

Website: www.aragen.com

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