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Genome Biologics
Genome Biologics is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country.
View Genome Biologics on Scientist.com
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Biomarkers
- Lipoprotein Associated Phospholipase A2 Testing Assess vascular inflammation and determine the risk for atherosclerosis or arterial plaque rupturing.
Cell Culture and Characterization
- Microphysiological system (MPS)/organoid analytics microTMA produced from fixed microtissues (MPS)
- Microphysiological Systems/organoid transcriptomics Microphysiological Systems/organoid transcriptomics
Disease Models
- Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
- Disease Simulation Modeling Disease Simulation Modeling
- Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
Show all 9 in Disease Models
- Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
- Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
- Ventricular Tachycardia Models Measure therapeutic endpoints in animal models of ventricular tachycardia.
DNA & RNA
- DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
- DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
- Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
- Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
- miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
- RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
Show all 10 in DNA & RNA
- RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
- shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
- siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Show all 55 services
Effectiveness
- In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.
Human Biological Samples
- Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
- Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
In Vitro Assays
- Cell Proliferation Measure cell number, cell viability and cell division.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
In Vitro Pharmacology
- Aptamer Products Obtain pre-made aptamers for specific target binding.
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
- In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Show all 9 in In Vitro Pharmacology
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Target Identification Identify the target(s) of a biologically active substance.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- Cardiac Channels Measure the arrhythmia producing potential of test compounds.
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
- Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
- Microelectrode Array Cardiotoxicity Assays Use microelectrode array to measure cardiotoxicity-related activities.
Show all 7 in In Vitro Toxicology
- Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
In Vivo Pharmacokinetics
- Cardiac Safety Assessment Assess cardiotoxicity using microelectrode assay technology.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
- Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
- Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Oncology Models
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Protein Sciences
- Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Target Animal and Human Food Safety
- Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.
Testing Services
- In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
-
Germany 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Genome Biologics is a Biotherapeutics company headquartered in Germany with a strong background and proven track record in in silico drug screening, in vivo preclinical drug testing and state-of-the-art transgenic technologies.
Established by industrial and academic experts and supported by leading academic institutions, CROs and the pharmaceutical industry, Genome Biologics combines the power of Artificial Intelligence based machine learning with big data, genomics and molecular science to rapidly identify drug-disease matches and generate complex in-vivo disease models.
- Website
- www.genomebiologics.com
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