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Jubilant Biosys
Jubilant Biosys is listed as a mid sized business research supplier in the Scientist.com network, with 4 sites in 2 countries and 3 service areas.
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Sites
4
Countries
2
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Biomarkers
- Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Cell Culture and Characterization
- Cell Services Most drug research projects routinely use a variety of cell research services including cell line construction, analysis of cells.
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Chemical and Compound Analysis
- Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Show all 90 services
Chemical and Compound Testing
- Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- Regulatory Starting Materials Sourcing regulatory starting materials (RSM)
Discovery Chemistry
- Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
- Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
- Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Show all 17 in Discovery Chemistry
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
- Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
- Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
- Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
- Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
Disease Models
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
DNA & RNA
- DNA Services From whole genome sequencing to large scale DNA and oligonucletotide synthesis, DNA services have become routine tools in drug ...
- RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
General in vivo Toxicology
- Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
- Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Show all 19 in In Vitro ADME
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- Mouse Lymphoma Assay Assay for DNA damage in cells exposed to test substances.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
- Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Show all 9 in In Vivo Pharmacokinetics
- Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Protein Binding Determine drug-protein binding interactions
- Protein Purification Isolate native or recombinant proteins from a sample.
- Protein Services Protein analysis and tagging are key steps in understanding the effects of compounds and treatments on your target disease outc...
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
REACH Services
- OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
- OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- New Request
Service areas:
Biology
Chemistry
DMPK
Where it operates
Sites by country, with the cities in each.
-
India 3 sites
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France 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Jubilant Biosys & Chemsys are part of Jubilant Life Sciences group providing innovative drug discovery solutions to the global pharmaceutical industry.With well enabled capabilities in Oncology, Metabolic Disorders, CNS, Pain and Inflammation, Jubilant Biosys has rapidly emerged as a leading collaborator for pharmaceutical and biotechnology companies worldwide. In each of these therapeutic areas, Jubilant has developed in-depth expertise in discovery informatics, medicinal chemistry, structural biology, biology, in vivo and in vitro biology and translational sciences. Combined with strong...
Show the full description
Jubilant Biosys & Chemsys are part of Jubilant Life Sciences group providing innovative drug discovery solutions to the global pharmaceutical industry.With well enabled capabilities in Oncology, Metabolic Disorders, CNS, Pain and Inflammation, Jubilant Biosys has rapidly emerged as a leading collaborator for pharmaceutical and biotechnology companies worldwide. In each of these therapeutic areas, Jubilant has developed in-depth expertise in discovery informatics, medicinal chemistry, structural biology, biology, in vivo and in vitro biology and translational sciences. Combined with strong clinical development and manufacturing capabilities, Jubilant has emerged as a fully integrated company with end-to-end solutions for drug discovery and development. Jubilant’s end to end research capabilities:
• Target class: GPCRs, Kinases, ion-channels, NHRs,Proteases, Epigenetics
• Broad Technology base: Many biochemical and cell based technologies
• Experience with in-vivo pharmacology and toxicology relevant to the diseases
• Integrated and robust preclinical and “early stage POC” portfolio management (CMC included) capabilities focused on outcomes
• Efficient Late Stage services and commercialization capabilities.
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- Website
- www.jubilantbiosys.com
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