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Research supplier
Across Barriers
Across Barriers is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 2 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Cell Culture Culture primary or immortalized cell lines.
Chemical and Compound Analysis
- Adsorption/Desorption Studies Obtain data on groundwater risk assessment.
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chemical Stability Measure the stability of small molecules in solution.
- Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Show all 7 in Chemical and Compound Analysis
- UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.
Chemistry, Manufacturing and Controls (CMC)
- API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
- API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Clinical Trials
- Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Show all 31 services
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
- Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Show all 7 in In Vitro ADME
- Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.
In Vitro Assays
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
Protein Sciences
- Protein Binding Determine drug-protein binding interactions
Testing Services
- Elevated Temperature Stability Determine the stability of a product at elevated temperature.
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
- In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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Germany 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
As an international operating contract research organization Across Barriers GmbH offers a wide range of services in the field of preclinical development, biopharmaceutics, (bio-) analytics and formulation development. It includes drug screening, drug delivery, compatibility and ICH stability services ranging from early development to Lifecycle Management. We are striving for establishing successful partnerships with companies of all sizes which are operating in different sectors of the pharmaceutical, cosmetics, chemical and biotechnology industries. Using tissues and cell cultures...
Show the full description
As an international operating contract research organization Across Barriers GmbH offers a wide range of services in the field of preclinical development, biopharmaceutics, (bio-) analytics and formulation development. It includes drug screening, drug delivery, compatibility and ICH stability services ranging from early development to Lifecycle Management. We are striving for establishing successful partnerships with companies of all sizes which are operating in different sectors of the pharmaceutical, cosmetics, chemical and biotechnology industries. Using tissues and cell cultures in the preclinical research (ADMET) consequently marks an intelligent and innovative step towards a faster, safer and less expensive development of modern active substances and formulations. We have implemented the following ADME models: - Dermal (Human and animal) - Ocular - Ungual - Gastrointestinal tract - Nasal, buccal - Blood- Brain Barrier - Respiratory tract
- Website
- www.acrossbarriers.de
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