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SGS Life Science Services

SGS Life Science Services is listed as a large business research supplier in the Scientist.com network, with 24 sites in 11 countries and 5 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 24

Countries 11

Type of company: Large business

Agricultural Sciences Compliance and Quality Control Measures

Master Seed Testing Test your Master Seed Bank or Master Virus Seed Stock (MVSS) to insure that the Working Virus Bank or Working Virus Seed Stock (WVSS) remains the same genotype and phenotype as the initial Master Seed Bank.
Residue Chemistry Pesticide residue and tolerance testing.

Agricultural Sciences Research & Development

Bacteriology PCR and MS-Based Bacterial Identification
Chemical and Physical Determination of chemical and physical properties of pesticide product.
DNA/Protein analysis Analyze DNA and proteins for allergens, pathogens and species identification.
Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties
Vaccines Testing transgenic plants as promising systems for vaccine production.

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Isotype Switching Modify antibody isotypes from any species to any human IgG isotype.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.

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Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
OmniRat Transgenic Animal Platform Produce humanized antibodies using a transgenic rat platform.
Pepscan Analysis Screen overlapping peptide sequences to identify linear epitopes.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.

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Bioimaging

Ab-Targeted Positron Emission Tomography Visualize sites of HIV replication that are difficult to access by tissue biopsies.
Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
In Vivo Positron Emission Tomography (PET) Imaging Image tumor progression or conduct biodistribution investigations in experimental animals injected with a radiolabeled molecular probe.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.

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In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Magnetic Resonance Imaging Use MRI to obtain chemical and physical information about molecules and map the internal structure of an object.
Medical Imaging Visualize and analyze internal structures in animal models or patients.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Photoactivated Localization Microscopy (PALM) Visualize and localize individual endogenous fluorophores.
Single Molecule Localization Microscopy Enable structural resolution of biological samples at the nanometer range using light in the visible spectrum.
SPECT-CT and PET-CT Imaging Get images that combine the spatial context of metabolic or biochemical activity with an anatomic image.
Thermal and Acoustic Imaging Measure the dielectric and optical properties of biological tissues corresponding to pathological states.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.

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Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
NBE Biomarkers Request information or a price quote for NBE Biomarkers services
Peptide Bioanalysis Analyze the structure of Peptides.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Authentication Verify the identity and purity of an experimental cell line or industrial culture.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

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Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Spectral Karyotyping Identify chromosomal abnormalties often not detected by traditional methods.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.
Yeast Cell Culture Grow yeast strains or species.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Atomic Absorption Analysis Measure the elemental composition of a diverse array of samples.
Atomic Force Microscopy Use atomic force microscopy to reveal information about the atomic topography and mechanical properties of a sample.
Centrifugal Precipitation Chromatography Separate analytes based on their solubility in ammonium sulfate solution.
Chemical Stability Measure the stability of small molecules in solution.

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Chiral Separation Purify therapeutically active isomers of drug candidates.
Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Computed Tomography Visualize the internal features of solid objects.
Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Energy Dispersive X-ray Spectroscopy Identify and estimate the elemental composition of a sample based on x-ray emission patterns.
Fluorescence Mediated Tomography Visualize the spatial distribution of fluorescencently labeled probes and substances.
GC MS Analysis Use gas chromatography coupled to mass spectrometry to analyze compound integrity.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Ion Exchange Chromatography Separate and detect analytes.
Light Sheet Fluorescence Microscopy Use a planar sheet of light to section transparent tissues and generate a 3D image.
Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Optical Tomographic Imaging Use multiply-scattered light to reconstruct images of illuminated objects.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Phase Contrast X-Ray Imaging Visualize dense and intricate samples with high spatial three-dimensional resolution.
Photostability Measure drug degradation rates after exposure to various light sources.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
Physicochemical Analysis Physicochemical Analysis of material or preparation evaluating (e.g.) particle size, composition, or compound structure.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Melting Point Analysis Assess protein stability by Differential Scanning Calorimetry (DSC) or Fluorimetry (Thermofluor) methods.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Stochastic Optical Reconstruction Microscopy (STORM) Visualize and localize individual fluorescent molecules.
Total Internal Reflection Fluorescence Microscopy Visualize single molecule fluorescence at a surface to produce high quality images with low background.
Ultrasound Tomography Use the transmission and acquisition of ultrasound waves to create a non-invasive technique for imaging.
X-ray Microscopy and Nanotomography (Nano-CT) Create two- and three-dimensional imaging of objects in real time.

Chemical and Compound Testing

Bacterial Water Analysis Analyzing water samples to identify the bacteria present.
Limulus Amebocyte Lysate (LAL) Test Detect bacterial endotoxins in raw materials used for the production of cosmetics products.
Nutritional Testing Analyze food safety, vendor specifications, foreign substance identification processes and nutritional labeling.
Product Testing Ensure product quality standards are met.
USP <2021> Microbial Enumeration Tests Estimate the total aerobic microbial count, total combined yeast and mold counts, and the presence of bile-tolerant gram-negative bacteria present in nutritional supplements.
USP <2022> Microbiological Procedures for Absence of Specified Microorganisms Determine the absence of objectionable organisms in nutritional supplements.

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USP <85> Bacterial Endotoxin Test Test to detect or quantify bacterial endotoxins that may be present in or on a sample.

Chemistry, Manufacturing and Controls (CMC)

API and drug product storage and release API and drug product storage and release
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
Bulk Raw Materials Acquire raw materials in large volumes at wholesale pricing.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services

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Compendial test methods Run Compendial test methods (e.g., KF)
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Drug Substance and Drug Product Characterization and Manufacturing Drug Substance and Drug Product Characterization and Manufacturing.
Emulsifiers & Solubilizers Acquire emulsifiers and solubilizers to use as ingredients in consumer healthcare products.
Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
ICH-compliant stability testing Perform ICH-compliant stability testing
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Tablet Manufacturing Use automatic or semi-automatic machinery to create various standard and non-standard tablets.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Clinical Consulting

Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Product Testing Consulting Expert advice to evaluate the effectiveness, quality, and legitimacy of a given item or good.
Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.
Comparator Drug Sourcing Streamline new drug development and clinical trials by comparing the efficacy of an experimental drug to a comparator drug.
IP Packaging Proper packaging of pharmaceutical products and goods is crucial to ensure the validity and quality of the product being supplied. Proper investigational product packaging is aided by the use of quality...

Data Science/Bioinformatics

Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.

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In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.
In Silico Nucleic Acid Microarray Analysis Use software to visualize and evaluate gene activity in response to various stimuli.
In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.
In Silico Protein Microarray Analysis Use software to visualize and evaluate protein function and expression on a large scale.
In Silico Protein Modification Analysis Use computational methods to predict the behavior of modified proteins.
In Silico Protein Sequence Analysis Use software to predict protein structural and functional features and secondary structure components.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
API Synthesis Synthesize small molecule candidates, proteins, peptides or large molecules according to GMP and cGMP guidelines.
Certified Standards Find certified standards for assays, tests and services.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Purchase Buy compounds, building blocks or compound libraries.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.

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Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Leachable and extractable testing Leachable and extractable testing
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
USP Testing Analytical Reagents Acquire chemical reagents, solution concentrates and volumetric solutions used to evaluate items in USP testing.
USP-NF Grade Chemicals Acquire chemicals that comply with United States Pharmacopeia and National Formulary standards.
UV and IR Profiling Analyze the integrity of a compound or large biomolecule.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
Cough Models Test the therapeutic efficacy of drug candidates in cough models.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.

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Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Ocular Inflammation Models Measure ocular inflammation in models of eye disorders such as uveitis and keratitis.
Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.

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RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.

Drug Metabolism and Pharmacokinetics (DMPK)

Biomarkers DMPK Biomarker DMPK and gene analysis services are critical tools in evaluating patients and discovery of new therapeutics.

Food Safety & Regulations

Water Activity Determine water activity in consumer healthcare products involving a USP or FCC monograph.

General in vivo Toxicology

Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.

General Marketing

Database Management Software Facilitate the collection, tracking and processing of biological facts, statistics and observations.

Human Biological Samples

Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...

In Vitro ADME

Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

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Cell Proliferation Measure cell number, cell viability and cell division.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro SPF (Sun Protection Factor) Testing Use in vitro test methods to measure the UVA protection performance of sun protection products.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Microbiology Study microbes and their role in human health.
Pathogen Assays Detect and distinguish viral, bacteria and fungal strains and species.
Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.

In Vitro Pharmacology

In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Zebrafish Embryo Toxicity Use a single animal species to create one models of toxicity.

In Vivo Pharmacokinetics

In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.

Lab Supplies, Facilities, and Equipment

Lab Equipment Installation & Calibration Install new or refurbish used laboratory equipment and calibrate to reference standards.
Lab Equipment Maintenance & Repair Conduct repairs for laboratory equipment or routine and preventative maintenance.

Management Optimization & Development Strategies

REACH Regulation Design Consultation for products within the European Union

Market Access

Market Research & Business Intelligence Run market feasibility studies, establish customer needs, improve product performance and analyze competition.

Medical Communications

Medical Publications Make clear and accurate presentations of scientific and technical data.

New Product Development

Vitamins Analysis Analyze vitamins in foods and dietary supplements either by HPLC or titration.

Other Specialty Toxicology

Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.
Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Microdilution Testing Simultaneously quantify the susceptibility of a microbial species or strain to multiple anti-microbial agents.
Raw Materials Testing Verify that raw materials are sterile and not contaminated by mycoplasma, virus or other microorganisms.
Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.

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Tumorigenicity Testing Test tumor-forming properties of cell products.
United States Pharmacopeia (USP) Testing Use USP standards to ensure quality of pharmaceuticals, supplements and food ingredients.
Viral Testing Characterize viral products for functional activity and possible contamination.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Product Development

Personal Care Product Development Services including the formulation, manufacturing, or designing of a personal/consumer care product or packaging.

Protein Sciences

Analytical Ultracentrifugation Characterize the interactions and properties of macromolecules in solution.
Carbohydrate Isolation Obtain pure monosaccharides, pure polysaccharides or related derivatives from samples.
Carbohydrate Isolation Protocol Development Design and optimize protocols for carbohydrate isolation.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.

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Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Identification Uncover or confirm the identity of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Raw Materials

Conditioners & Emollients (Hair & Skin Care) Acquire conditioners and emollients to use as ingredients in consumer healthcare products.

REACH Services

OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Scientific Data Services

Bayesian Statistics Extract information from data sets that are subject to error or noise to see unobserved possibilities.
Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Data Infrastructure Design and deploy an information management solution suited to users' specific needs.
Data Quality Framework Manage data quality issues to maintain good quality data outputs.
Database Integration Convert bioinformatics results from multiple data sources (DSs) into a single operational format.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.

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Epigenomics Data Analysis Quantify and analyze DNA methylation and/or DNA binding protein data sets.
In Silico Genomics/Transcriptomics Data Analysis Interpret DNA sequencing and microarray data.
In Silico Metagenomics/Metatranscriptomics Data Analysis Use software to analyze genomic information from multiple environmental sources.
Machine Learning/ AI Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)
Marker Analyses Identify associations between genetic markers and traits of interest to determine markers responsible for human diseases.
Molecular Dynamics Software Run simulations that determine time-dependent behaviors of molecular systems.
Molecular Phylogenetics Analyze hereditary molecular differences in genomic sequences to compare genomes.
Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
Pharmaco-genomics Genetic polymorphism contribution to inter-individual variability in drugs' responses and/or adverse events.
Scientific Data Visualization Exploration and reporting of data by means of graphs and plots.
Systems Biomedicine Analyze complex interactions in biological systems with interdisciplinary scientific teams.
Systems Network Analysis Analyze and visualize molecular pathways including gene regulatory, protein-protein and drug-target networks.
Systems Pharmacology Understand how drugs interact with different molecular and cellular systems within biological models.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Characteristic Testing Characterization of physical and chemical properties of raw materials
Consumer Care Testing and Substantiation Test personal care products using analytical, in vitro, and microbial test services
Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Human Repeat Insult Patch Test (HRIPT) Examples of which include Topical Irritation, Allergenicity, Phototoxicity and Photoallergy testing.

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In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Microbiological Sterility Testing Test the presence of viable microorganisms.
Non-Acnegenicity & Non-Comedogenicity Test Test whether a cosmetic product is likely to cause acne and comedones (pimples).
Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
Ocular Irritation Test Use human subjects to determine whether a cosmetic product or ingredient can cause ocular irritation.
OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.
OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.
OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
Raw Material Microbiological Testing Examples of which include Microbial Content using USP <61> and <62> and other standards, LAL Endotoxin, Ames Mutagenicity and Sterility.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Safety In-Use Studies Safety-in-use studies assess the potential for a product to elicit adverse reactions under normal use conditions.
Sebum Production Testing to evaluate the oil production in the skin
USP 51 Cosmetic Preservative Efficacy Test Evaluate the antimicrobial stabilization of a cosmetic product as per USP 51.
USP <61> Microbial Limits Test Determine whether a substance or preparation complies with an established specification for microbiological quality.
USP <62> Microbial Limits Test Determine the presence or absence of specific microorganisms.
UVA Protection Efficacy Evaluation of UVA protection using JCIA or ISO 24442

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Service areas:

Biology Chemistry DMPK Toxicology Clinical

Germany Aachen, Berlin, Munich, Taunusstein, Wiesbaden 5 sites
France Saint-Benoit, Villeneuve-la-Garenne, ZA Pierre Loti 3 sites
Switzerland Baar, Birsfelden, Plan-Les-Ouates 3 sites
United States Bloomfield, Fairfield, Lincolnshire 3 sites
Canada Markham, Mississauga 2 sites

Showing 5 of 11 countries.

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SGS Life Science Services is a network of contract testing laboratories, with 21 laboratories in 12 countries, offering a services for the quality control of raw materials, APIs, excipients and finished products.

Professional associations: AAPS, BioNJ, MDBio
Website: www.sgs.com/pharma

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