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Sapien Biosciences

Sapien Biosciences is listed as a small business research supplier in the Scientist.com network, with 3 sites in 1 country.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 3

Countries 1

Type of company: Small business

Antibodies

Immunodetection Use antibodies to identify a protein or antigen.

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.

Biomarkers

Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Cytogenetics Examine the structure and function of the cell, especially chromosomes.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.

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Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Osteoclasts Measure osteoclast activity and bone resorption in human, mouse or rat assays.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.

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Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
H & E Services For requesting services related to H&E Services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
Microsatellite Instability Analysis Compare allelic profiles and detect genomic instability.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.

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Chemical and Compound Analysis

Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...

Developmental and Reproductive Toxicology (DART)

Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Discovery Chemistry

Natural Product Screening Screen large natural product collections for therapeutic activity.

Disease Models

Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

Amplified Fragment Length Polymorphism Detection Detect DNA polymorphisms based upon restriction enzyme digestion and PCR.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
Methylation Specific PCR Determine the methylation status of a CpG site without the need for base-specific endonucleases.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.

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Restriction Fragment Length Polymorphism Identification Uses gel electrophoresis to identify differences in restriction fragment lengths produced by enzymatic digestion of DNA.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
Sequence Based Methylation Analysis Detect DNA methylation sites within cytosine-phosphate-guanine (CpG) dinucleotides at single base-pair resolution.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.

HEOR

Patient Treatment Patterns Assessment of treatment processes and patterns within clinical practice.
Therapy Switch Insight into the reasoning of patients switching treatments and the outcomes of the switch.

Human Biological Samples

Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
HBS Alzheimer's Acquire fresh, frozen, or fixed Alzheimer's tissues or other related Alzheimer's HBS.
HBS Amyotrophic Lateral Sclerosis (ALS) For requesting HBS Amyotrophic Lateral Sclerosis (ALS).
HBS Asthma For requesting HBS Asthma.
HBS Chronic Obstructive Pulmonary Disease (COPD) Acquire fresh, frozen, or fixed COPD tissue or for requesting other COPD human biospecimen samples.

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HBS Diabetes For requesting HBS Diabetes.
HBS Huntington's For requesting HBS Huntington's.
HBS Leukemia For requesting HBS Leukemia
HBS Parkinson's For requesting HBS Parkinson's
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human Ascites Acquire fresh/frozen Ascites based on patient demographics, disease stage, treatment and history.
Human Biofluids Acquire fresh/frozen biofluids based on patient demographics, disease stage, history and treatment.
Human Bone Marrow Aspirates Acquire fresh/frozen Bone Marrow mononuclear cells based on patient demographics, disease stage, treatment and history.
Human Bone Marrow Cells Acquire fresh, frozen, or fixed normal bone marrow based on patient demographics and history.
Human Cell Lysates For requesting human Cell lysates.
Human Cerebral Spinal Fluid (CSF) Acquire fresh/frozen normal cerebrospinal fluid based on patient demographics and history.
Human DNA Acquire human DNA.
Human DNA & RNA Acquire fresh/frozen Human DNA & RNA based on patient demographics, disease stage, treatment and history
Human Fixed Tissue Acquire Human fixed tissue based on patient demographics, disease stage, history and treatment.
Human Frozen Tissue For requesting frozen human tissue.
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Saliva Acquire fresh/frozen normal saliva based on patient demographics and history.
Human Synovial Fluid Acquire fresh/frozen normal synovial fluid based on patient demographics and history.
Human Tears Acquire fresh/frozen Tears based on patient demographics, disease stage, treatment and history.
Human Urine Acquire fresh/frozen normal urine based on patient demographics and history.
Human Vitreous Humor Acquire fresh/frozen normal vitreous humor based on patient demographics and history.
Stomach Cancer Human Fixed Tissue Acquire fixed Stomach Cancer tissue based on patient demographics, disease stage, treatment and history.

In Vitro ADME

Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

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Cell Proliferation Measure cell number, cell viability and cell division.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
Microbiology Study microbes and their role in human health.
Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

In Vitro Pharmacology

Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.

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In Vitro Oncology Models Use cell-based and biochemical models of cancer.

In Vitro Toxicology

Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.

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Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.
Zebrafish Embryo Toxicity Use a single animal species to create one models of toxicity.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Model Development

Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.

Old Category HEOR, RWE, Market Access

Non-Interventional Studies Examine different aspects of drug usage, including efficacy and safety, under real-life conditions.

Other Specialty Toxicology

Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.
Phototoxicity Determine whether drug treatment causes light-activated toxic effects.
Tumorigenicity Testing Test tumor-forming properties of cell products.

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Real World Evidence & Data

Clinical Phenotype Data Obtain phenotypic data and observations on patients such as the clinical manifestation of the disease, clinical and behavioral parameters, symptoms, and laboratory test results.
Exploratory Study Explore study design, outcomes, data-collection method, and selection of population for a topic that needs more research information.
Real World Evidence (RWE) Studies Studies (prospective or retrospective) utilizing data obtained from "real world settings" , and is outside the tight controls of a clinical trial design.
Real-World Data Acquire real-world data from patients' electronic medical records including clinical information generated during the course of healthcare.
Real-World Evidence Acquire clinical data from patients' medical records to analyze trends and the frequency of occurrence of different medical conditions.
Registries - Disease Database containing, through utilizing observational research methods, standardized data about patients who have the same disease.

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Registries - Patient Database containing, through utilizing observational research methods, standardized data about patients who have the same condition, disease, or exposure and is used to evaluate an outcome
Retrospective Exploratory Studies Retrospective exploratory studies
RWD - Diagnostics/Laboratory Includes information on laboratory procedures/results.
RWD - Electronic Medical Record (EMR) Digital version of a patient's medical or health chart containing demographic, clinical, medical, and other treatment information.
RWD - Genomics Genomic data collected from a patients with different diseases, can be derived from a range of sources.
RWD - Oncology Data from oncology patients, can include clinical treatment, diagnosis, among others.
RWE/RWD Observational Research Research method for documenting clinical, economic, and or humanistic outcomes of actual medical practice absent the constraints of a more formal experimental design. See also Pragmatic Clinical Trials.

Safety Pharmacology

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.

Scientific Data Services

Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.

Other services

New Request  
Observational Research Gain valuable insights into the association between a drug treatment and its outcomes such as long-term effectiveness and safety.

India Hyderabad 3 sites

Sapien Biosciences is a joint venture between Apollo Hospitals & Saarum Innovations to create a world-class bio-bank and personalized medicine company that leverages Apollo’s leadership position in healthcare and Saarum’s cutting-edge life sciences research expertise for novel clinical and R&D applications. Sapien’s primary objective is to build a high-quality bio-repository that integrates ethically consented human samples with associated medical, pathological & diagnostic data and leverage this resource to develop & deliver high-end diagnostic applications. Further Sapien will partner...

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Sapien’s primary objective is to build a high-quality bio-repository that integrates ethically consented human samples with associated medical, pathological & diagnostic data and leverage this resource to develop & deliver high-end diagnostic applications. Further Sapien will partner with healthcare enterprises and drug discovery companies globally to study disease epidemiology, validate new diagnostics, identify new drug targets and evaluate new drugs.

Sapien has exclusive access to the entire Apollo network for its bio-banking needs but will partner with additional research-oriented hospitals and clinics for their personalized medicine and bio-banking needs. Further Sapien has entered into an alliance with Apollo Hospitals that allows Sapien to front-end Apollo’s personalized medicine initiatives. This allows Sapien to bring novel cutting-edge diagnostics to Apollo, either on its own or in collaboration with best-of-breed institutions world-wide thereby enabling world-class healthcare and improving patient outcomes.

Sapien Biosciences is launching its first & novel personalized medicine test,‘myPLATELET‘ which determines patients’ response to their blood-thinning medicationand supports decision-making by their cardiologists to personalize therapy for better outcomes. This is the only test in India that combines both genetic and platelet function response to enable tailored anti-platelet therapy for each patient.

Also in development are other tests designed to assess genetic risk factors for major diseases, predict response to treatments etc. Sapien is engaging with leading collaborator companies to launch such innovative personalized medicine tests.

Website: sapienbio.co.in

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