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TCG LifeSciences
TCG LifeSciences is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country and 4 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Agricultural Sciences Research & Development
- Agro-product Storage Stability Testing Monitor agro-product changes over time to optimize packaging, storage conditions and product longevity.
- Agrochemical Analytical Method Development Engineer sensitive and selective methods that meet GLP validation requirements to assess different agrochemical properties.
Biomarkers
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Chemical and Compound Analysis
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chemical Stability Measure the stability of small molecules in solution.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- Compound Integrity Analyze the identity and purity of small molecule drug candidates.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Show all 8 in Chemical and Compound Analysis
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Chemical and Compound Testing
- Product Testing Ensure product quality standards are met.
Show all 88 services
Chemistry, Manufacturing and Controls (CMC)
- Bulk Manufacturing Find facilities for large-scale mass production.
- Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Discovery Chemistry
- Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
- Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.
Show all 13 in Discovery Chemistry
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
- Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
Disease Models
- Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
- Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
- Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
- General Pain Models Measure therapeutic endpoints in animal models of general pain.
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Show all 14 in Disease Models
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
- Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
- Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
- Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
- Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
- Pain Models Test therapeutic efficacy of drug candidate in pain model.
- Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.
General in vivo Toxicology
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Show all 16 in In Vitro ADME
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Multidrug Resistance Identify potential causes of drug-drug interactions.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Reference Standards Find reference standards for assays, tests and services.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- Glucose Release Assay Determine free glucose levels in biological samples.
Show all 8 in In Vitro Assays
- HTS Assay Development Develop assays to use in high throughput screening.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
In Vitro Pharmacology
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
- In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
In Vitro Toxicology
- Cardiac Channels Measure the arrhythmia producing potential of test compounds.
- Cytotoxicity Test for effects on cell viability and proliferation
In Vivo Pharmacokinetics
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Oncology Models
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
-
India 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
TCG Lifesciences Limited (formerly "Chembiotek Research International") is a leading contract research services company in the area of early drug discovery and development. We started our operations in the year 2001 in India, currently we have our presence in United States, Europe, Japan and Australia. We have a strong talent pool of 800+ qualified and trained scientists, drawn from the best national and international institutes and industry. Spread over 250,000 sq. ft. of space our services span from specific solutions to integrated discovery projects across multiple therapeutic areas...
Show the full description
TCG Lifesciences Limited (formerly "Chembiotek Research International") is a leading contract research services company in the area of early drug discovery and development. We started our operations in the year 2001 in India, currently we have our presence in United States, Europe, Japan and Australia.
We have a strong talent pool of 800+ qualified and trained scientists, drawn from the best national and international institutes and industry.
Spread over 250,000 sq. ft. of space our services span from specific solutions to integrated discovery projects across multiple therapeutic areas with focus on Central Nervous System (CNS), Inflammation & Pain, Metabolic Disorders and Infectious Diseases. Our research infrastructure includes world class chemistry and biology laboratories, animal facility, electrophysiology laboratory, BSL 2 and 3 laboratory, and cGMP facilities at our R&D centers in Kolkata and Pune, India.
Vision
Partner with global pharma and biotechnology companies and collaboratively discover new molecules to address the unmet medical needs. Collaborate with bio-medical researchers, research institutions and academia to accelerate generation of knowledge and leverage innovation and technology platforms.
Sponsor
We are a part of ‘The Chatterjee Group’ (TCG), a global investment conglomerate headquartered in New York with strategic investments of over USD 1 Billion. The group is established by Dr. Purnendu Chatterjee. TCG is internationally known for generating significant capital appreciation through long term strategic investments, both in the private and public sectors. .
- Professional associations
- AAPS, ACS, BioFlorida, BioNJ, DCAT, MassBio, NCBIO, SCBIO
- Website
- www.tcgls.com
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