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ChemPartner

ChemPartner is listed as a large business research supplier in the Scientist.com network, with 5 sites in 2 countries and 5 service areas.

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Sites 5

Countries 2

Type of company: Large business

Agricultural Sciences Research & Development

Chronic Whole Effluent Toxicity(WET) Test Identify the effluent dilution that impairs growth, development or reproduction in aquatic organisms in 7 or more days of exposure.

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Isotype Switching Modify antibody isotypes from any species to any human IgG isotype.
Antibody Phage Display Screen for Ab–protein, Ab–peptide, and Ab–DNA interactions by using bacteriophages that express antibodies.

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Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Therapy Efficacy In vivo assessment of monoclonal/bispecific antibody efficacy in a humanized mouse
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
Immunodetection Use antibodies to identify a protein or antigen.
In Silico Humanization Predict epitope binding specificity, increase in vivo half-life and allow rapid modeling and humanization of antibodies.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
OmniRat Transgenic Animal Platform Produce humanized antibodies using a transgenic rat platform.
Pepscan Analysis Screen overlapping peptide sequences to identify linear epitopes.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.

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Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Islet Cell Autoantibodies (ICA) Testing Detect Type 1 diabetes-related autoantibodies.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Protein Glycosylation Mapping Technique Map glycosylation sites in proteins using liquid chromatography and mass spectrometry.
Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

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Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Authentication Verify the identity and purity of an experimental cell line or industrial culture.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.

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Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Stem Cell Methodologies Study Stem Cell characteristics.

Chemical and Compound Analysis

Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.

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NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.
Protein Melting Point Analysis Assess protein stability by Differential Scanning Calorimetry (DSC) or Fluorimetry (Thermofluor) methods.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Solid State Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solid samples.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Spray Drying Convert a liquid into a powder by rapidly drying the mixture and removing the moisture component.
Structural Chemistry Examine the relationship between protein structure and function.

Chemistry, Manufacturing and Controls (CMC)

Analytical Development and Validation Request services related to Analytical Development and Validation
API and Drug Product Stability Testing API and Drug Product Stability Testing.
API and drug product storage and release API and drug product storage and release
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Bulk Manufacturing Find facilities for large-scale mass production.

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Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Crystallization studies Crystallization studies
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
ICH-compliant stability testing Perform ICH-compliant stability testing
Integrated Antibody Development Package-Europe Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...
Integrated Antibody Development Package-UK Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...
Milling, grinding, spray-drying Milling, grinding, spray-drying
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Subcellular Fraction Test System Obtain human, minipig, mouse, or rat dermal microsomes as in-stock standard test systems for the development of safer topical and transdermal products.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Companion Diagnostics

Cervical Cancer CDx Design and validate companion diagnostics for cervical cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Osteoarthritis CDx Design and validate companion diagnostics for osteoarthritis that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Pancreatic Cancer CDx Design and validate companion diagnostics for pancreatic cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Rheumatoid Arthritis (RA) CDx Design and validate companion diagnostics for RA that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

Data Science/Bioinformatics

In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Protein Modification Analysis Use computational methods to predict the behavior of modified proteins.
Proteome Data Analysis Find tools for analysis of homology and similarity, protein function and structural properties.
Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.

Developmental and Reproductive Toxicology (DART)

Bioelectronics Evaluate an application (e.g. device) that integrates biological materials and micro and nano-electronics.
Embryo-Fetal Development (EFD) Study (Segment II) Test drug candidate in Segment II toxicology services.
Enhanced Pre/Post-Natal Development Study (ePPND) - Monkey / Non-human Primate Conduct a study that combines in utero and postnatal assessments of your compound in monkeys/non-human primates.
Fertility and Embryonic Development Study (Segment I) - Mouse Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in mice.
Juvenile Toxicity Study - Dog / Canine Conduct a study to determine the differences in toxicity between immature and mature systems in dogs.
Juvenile Toxicity Study - Other Species Conduct a study to determine the differences in toxicity between immature and mature systems in other species.

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Juvenile Toxicity Study - Rat Conduct a study to determine the differences in toxicity between immature and mature systems in rats.
Pre/Post-Natal Development (PPND) Study (Segment III) - Mouse Conduct a study to quantify the effect of your compound on fetal development, parturition, and post-natal development in mice.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.

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Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Auto-immune Hepatitis Models Measure therapeutic endpoints in animal models with auto-immune hepatitis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.

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Comparative Pharmacology Compare drug responses across species for improved reliability in translational studies.
Cyp2f2 Knockout Mouse Study Cyp2f2-mediated lung metabolism.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Disease Simulation Modeling Disease Simulation Modeling
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
Excitotoxicity Models Measure therapeutic endpoints in animal models with excitotoxic pathology.
Fecal Microbiota Transplantation (FMT) - Mouse Use germ-free mice to evaluate the properties of complex or defined gut microbiota following fecal microbiota transplantation (FMT). Axenic (germ-free) mice transplanted with donor microbiota can be utilized to assess...
General Pain Models Measure therapeutic endpoints in animal models of general pain.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Obese Primates Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
SHR/NCrl Rat Use a single animal species to create one or more disease models fior hematopoesis.
Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
qPCR Analysis Measure the accumulation of PCR products in real time.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.

Drug Development

Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.

General in vivo Toxicology

Carcinogenicity Study - Mouse Conduct a repeat dose, chronic carcinogenicity study in mice to determine the tendency of your compound to produce tumors.
Carcinogenicity Study - Rat Conduct a repeat dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dose Range Finding Study - Dog /Canine Conduct a study to determine the dose range of your compound in dogs/canines.
Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
Effective Dose (ED), 50% Toxicity Test Quantify the diluted toxin needed to induce sub-lethal effects upon constant exposure in half of test organisms.

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IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Repeat Dose Toxicity Study - Dog / Canine Conduct a repeat dose study in dogs to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Monkey / Non-human Primate Conduct a repeat dose study in monkey/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Other Species Conduct a repeat dose study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Short-Term Toxicity Tests Acquire preliminary data about the concentrations, exposure duration and effects of a toxin on organisms.
Single Dose Acute Toxicity Study - Dog / Canine Conduct a single dose study in Dogs and Canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Monkey / Non-human Primate Conduct a single dose study in Monkeys and Non-human Primates to determine the toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.

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Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression

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Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
ELISpot Assay and Testing Detect low levels of antigens.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Human Immuno-deficiency Virus Infection CDx Design and validate companion diagnostics for HIV infection that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Immunofocus™ Predict the response to anti PD1/PDL1 directed therapies.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Serine Protease Assay Detect apoptosis by measuring protease activity.

In Vitro Pharmacology

B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.

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Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
SELEX Select and identify highly specific aptamers with binding affinities comparable to traditional antibodies.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.

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Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Microelectrode Array Cardiotoxicity Assays Use microelectrode array to measure cardiotoxicity-related activities.
ToxTracker assay An assay for detection of signaling pathways underlying carcinogenicity/genotoxicity.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine Conduct a bile duct cannulation (BDC) study in dogs/canines to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Monkey / Non-human Primate Conduct a bile duct cannulation (BDC) study in monkeys/non-human primates to support the absorption, distribution, metabolism and excretion profiling of your compound.
Expired Air Study - Mouse Conduct a study to collect expired air and monitor its radioactivity content in mice.
Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Minipig Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in minipigs.

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Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Mass Balance Study - Other Species Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in other species.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Ocular Distribution Study - Dog / Canine Conduct a study to determine the distribution of your compound in ocular tissues of the dog/canine.
Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Show all 17 in In Vivo Pharmacokinetics 11 more

Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rabbit Conduct a pharmacokinetic screening study in rabbits that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
Disease Model Database For sourcing disease models.
In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.

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NMRI Mouse Use a single animal species to create one or more disease models for cachexia and hemophilia.
Non-Human Primate Models Use a single animal species to create one or more disease models.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
PiggyBac Transgenic Mouse Service Obtain single-copy transgenic embryos with consistent expression of any desired transgene.
Pre-clinical Animal Surgery Conduct surgey in animals used as pre-clinical models.
Pseudopregnant CD1 Mouse Use a single animal species to create gene-modified mouse models.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Neurotoxicology

Single Dose Acute Neurotoxicity Study - Other Species Conduct a single dose study in other species to determine the neurotoxicty of your compound.
Single Dose Acute Neurotoxicity Study - Rat Conduct a single dose study in rats to determine the neurotoxicty of your compound.

Non-Human Biospecimen

Dog / Canine Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Dog / Canine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Dog / Canine Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Monkey / Non-Human Primate / NHP Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

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Mouse Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Non-Human Biospecimen Finder Explore listings of Non-Human Biological Samples from the suppliers on the scientist.com NHBS database.
Rabbit Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Digestive System PDX Patient derived xenografts relating to organs and components of the digestive system. This includes, but is not limited to the Stomach, Intestines, Liver, Colon, Colorectal samples and Gastric samples.
Endocrine System PDX Patient derived xenografts related to the endocrine system. PDX related to glands controlling hormone regulation such as the Pituitary glands, Thyroid Glands, Adrenals, and Pancreas.
Endocrine System Xenograft Xenografts derived from organs and glands of the Endocrine system. This include samples from the Pituitary Gland, Thyroid, and Adrenals.

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Experimental Metastatic Models Measure therapeutic endpoints in animal models of experimental metastatic cancer.
Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
Murine Adenocarcinoma 16 (MAC16) Murine Test for therapeutic efficacy of drug candidates in muscle wasting models.
NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.
Nervous System Xenografts Xenografts relating to the Nervous system. This includes samples from the Head, Neck, Brain, and Nerves.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
Reproductive System PDX Patient derived xenografts relating to reproductive systems. This includes PDX from reproductive organs such as the Ovaries, Cervix, Breasts, Testes, Prostate, and Scrotum.
T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.
Urinary System PDX Patient Derived Xenografts relating to organs that comprise the Urinary system. This includes, but is not limited to, samples from the Kidneys, Liver, and Bladder.
Urinary System Xenografts Xenografts derived from organs of the Urinary system. This includes, but is not limited to, xenografts from the Bladder, Kidney, and Urethra.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Cutaneous Phototoxicity Study - Guinea Pig Conduct a study in guinea pigs to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Cutaneous Phototoxicity Study - Mouse Conduct a study in mice to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Cutaneous Phototoxicity Study - Other Species Conduct a study in other species to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Cutaneous Phototoxicity Study - Rat Conduct a study in rats to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Hypoaspis Toxicity Tests Use Hypoaspis mortality to measure the short-term impact of a single or multiple exposure(s) to a test chemical.

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Ototoxicity Study - Monkey / Non-human Primate Conduct a study in monkeys/non-human primates to determine the potential for your compound to cause hearing loss.
Ototoxicity Study - Mouse Conduct a study in mice to determine the potential for your compound to cause hearing loss.
Ototoxicity Study - Other Species Conduct a study in other species to determine the potential for your compound to cause hearing loss.
Phototoxicity Determine whether drug treatment causes light-activated toxic effects.
Semi-Static Acute Toxicity Test Measure toxicity endpoints in aquatic organisms exposed to renewed test solutions at defined intervals of an experiment.
Static Acute Toxicity Test Measure toxicity endpoints in aquatic organisms exposed to a non-renewed test solution for the entire experiment.

Product Orders

Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Analytical Ultracentrifugation Characterize the interactions and properties of macromolecules in solution.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.

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Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
Low Density Lipoprotein (LDL) Uptake Assay Investigate low density lipoprotein uptake and regulation at the cellular level.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
PEG Protein Conjugation Improve the therapeutic or pharmacokinetic properties of a protein by pegylation.
Peptide Derivatives Acquire chemicals that are peptide derivatives.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Phage Display Use in vitro screening method to identify protein binding partners.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Engineering Alter the features or properties of a protein for a specific purpose.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein mapping Interrogate the entire sequence of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

REACH Services

Ex Vivo REACH Assays Perform testing on cells or tissues cultured directly from a test organism
Hazard, Exposure and Risk Assessment Evaluate the known hazard of a test compound in conjunction with the expected quantity and frequency of exposure.
In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 402: Acute Dermal Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test chemical by dermal route.
OECD 403: Acute Inhalation Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation.
OECD 406: Skin Sensitisation This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application.

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OECD 407: Repeated Dose 28-day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 410: Repeated Dose Dermal Toxicity: 21/28-day Study This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance.
OECD 411: Subchronic Dermal Toxicity: 90-day Study This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance.
OECD 412: Subacute Inhalation Toxicity: 28-Day Study This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data...
OECD 413: Subchronic Inhalation Toxicity: 90-day Study This revised Test Guideline 413 (TG 413) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a period of 90 days, and to provide data for quantitative...
OECD 414: Prenatal Developmental Toxicity Study This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism.
OECD 416: Two-Generation Reproduction Toxicity This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive...
OECD 417: Toxicokinetics Study Obtain data on absorption, distribution, metabolism, and elimination of test substances.
OECD 420: Acute Oral Toxicity - Fixed Dose Procedure A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use...
OECD 421: Reproduction/Developmental Toxicity Screening Test The test substance is administered in graduated doses to several groups of males and females.
OECD 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.
OECD 423: Acute Oral toxicity - Acute Toxic Class Method The acute toxic class method set out in this Guideline is a stepwise procedure with the use of 3 animals of a single sex per step. Depending on the mortality and/or the moribund status of the animals, on average 2-4...
OECD 425: Acute Oral Toxicity: Up-and-Down Procedure The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling...
OECD 426: Developmental Neurotoxicity Study A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development.
OECD 429: Skin Sensitisation (Local Lymph Node Assay) Assess the skin sensitization potential of chemicals.
OECD 436: Acute Inhalation Toxicity – Acute Toxic Class Method The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according...
OECD 451: Carcinogenicity Studies The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test...
OECD 452: Chronic Toxicity Studies Evaluate the direct and indirect impact of prolonged and repeated toxin exposure to test organisms.
OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
OECD 475: Mammalian Bone Marrow Chromosomal Aberration Test The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese...
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.

Safety Pharmacology

Abuse and Dependence Liability Testing Determine the abuse or dependence potential of a therapeutic.
Conditioned Place Preference or Aversion Study - Mouse Conduct a study to establish the aversion or conditioned place preference and determine the motivational effect of your compound in mice.
Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Jacketed External Telemetry (JET) Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Jacketed External Telemetry (JET) Study - Minipig Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in minipigs.
Microelectrode Array Neurotoxicity Assays Use microelectrode array to measure neurotoxicity-related activities.

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Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Repeat Dose Neurotoxicity Study - Other Species Conduct a repeat dose study in other species to determine the neurotoxicity of your compound.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Safety Pharmacology Latin Square Study - Monkey / Non-human Primate Conduct a safety pharmacology study with a Latin square design in monkeys/non-human primates.
Telemetry Use implantable or external devices to study physiological parameters in model organisms

Scientific Data Services

Epigenomics Data Analysis Quantify and analyze DNA methylation and/or DNA binding protein data sets.
T Cell Epitope Mapping Use peptide libraries make it possible to rapidly identify the epitopes of T-Cells, T-Cell clones, T-Helper Cell Clones, T-cell lines, and unpurified T-cells.

Specialty Dosing Routes

Intracameral Implant Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct an intracameral implant toxicity study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Intracameral Implant Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct an intracameral implant toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Intracameral Implant Toxicity and/or Toxicokinetic Study - Other Species Conduct an intracameral implant toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct an intravitreal ocular toxicity study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Minipig Conduct an intravitreal ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct an intravitreal ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.

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Intravitreal Toxicity and/or Toxicokinetic Study - Other Species Conduct an intravitreal ocular toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Rabbit, Non-pigmented (New Zealand White; NZW) Conduct an intravitreal ocular toxicity study in non-pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Rabbit, Pigmented (Dutch Belted, New Zealand Red) Conduct an intravitreal ocular toxicity study in pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Lethal Dose (LD), 50% Toxicity Test Measure acute toxicity by identifying the amount of pure toxin required to kill half of the experimental subjects.
Repeat Dose Intranasal Study - Dog / Canine Conduct a repeat dose intranasal study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Monkey / Non-human Primate Conduct a repeat dose intranasal study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Dog / Canine Conduct a repeat dose intravenous infusion study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Monkey / Non-human Primate Conduct a repeat dose intravenous infusion study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Dog / Canine Conduct a single dose intranasal study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Dog / Canine Conduct a single dose intravenous infusion study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to dogs/canines.
Topical Dermal Toxicity and/or Toxicokinetic Study - Minipig Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to minipigs.
Topical Dermal Toxicity and/or Toxicokinetic Study - Monkeys/Non-human Primates Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to monkeys/non-human primates.
Topical Dermal Toxicity and/or Toxicokinetic Study - Mouse Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to mice.
Topical Dermal Toxicity and/or Toxicokinetic Study - Other Species Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to other species.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rabbit Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rabbits.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rat Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rats.
Topical Ocular Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct a topical ocular toxicity study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Minipig Conduct a topical ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct a topical ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Mouse Conduct a topical ocular toxicity study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Non-pigmented (New Zealand White; NZW) Conduct a topical ocular toxicity study in non-pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rat Conduct a topical ocular toxicity study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.
Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.
Phototoxicity and Photosensitization Screening Screen a consumer healthcare product for irritancy and/or allergy potential following exposure to UV light.
Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.

Other services

3D Vascularized Tumor Microenvironment Use microfluidic technology for the in vitro generation of living 3D perfused organ microenvironments.
In Vitro Neurodegenerative Disease Platform Use an IVND platform to screen different compounds/drugs in a finely controlled synaptopathies scenario.
New Request  
Qube - High Throughput Screening Screen large compound libraries for ion channel blockers and modulators.

Service areas:

Biology Chemistry DMPK Pharmacology Toxicology

China Shanghai, Chengdu Shi, Qidong 4 sites
United States WATERTOWN 1 site

ChemPartner is a leading contract research organization (CRO) providing a broad range of high-quality, integrated services across both drug discovery and drug development to help pharmaceutical and biotechnology companies discover and develop novel drug candidates efficiently. The Company today has a team of nearly 2000 skilled scientists in 1 million square feet of state-of-the-art research facilities and office space, including 71,500 sq.ft. (6,645 m2) animal facilities (AAALAC Full Accreditation) and 350,000 sq.ft. (32,600 m2) pharmaceutical development facilities including cGMP quality...

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