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Creative Biolabs

Creative Biolabs is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 6 service areas.

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Type of company: Small business

Agricultural Sciences Research & Development

Vaccines Testing transgenic plants as promising systems for vaccine production.

Antibodies

Affinity Maturation Use mutagenesis to optimize a complementary determining region and increase antibody affinity.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.

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Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Hybridoma Production Produce monoclonal antibodies, involving mouse immunization, fusion, subcloning and antibody production.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.
Yeast Display Discover or optimize eukaryotic proteins and antibodies that contain post translational modifications

Bioimaging

Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.

Biomarkers

Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.

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Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Atomic Force Microscopy Use atomic force microscopy to reveal information about the atomic topography and mechanical properties of a sample.
Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Isothermal Titration Calorimetry An ITC assay will be established and optimised for the affinity measurement of test substance to target molecule.

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Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.
Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemistry, Manufacturing and Controls (CMC)

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Formulation Services Assistance when determining the look, texture, fragrance of a product with compatibility with product packaging, knowledge of competitive performance traits and product shelf life.

Clinical Trials

Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Developmental and Reproductive Toxicology (DART)

Bioelectronics Evaluate an application (e.g. device) that integrates biological materials and micro and nano-electronics.
Juvenile Toxicity Study - Other Species Conduct a study to determine the differences in toxicity between immature and mature systems in other species.

Discovery Chemistry

Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Electroencephalogram EEG Models Record electrical activity along the scalp of animal models or human patients.
Excitotoxicity Models Measure therapeutic endpoints in animal models with excitotoxic pathology.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.

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In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
Optogenetics (rodent behavioral testing) Use light to selectively control the molecular events in cells of living organisms.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
Stroke Models Measure therapeutic endpoints in animal models of stroke.

DNA & RNA

DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
Genotyping Examine a DNA sequence to identify specific genetic varients .
In Situ Hybridization Localize specific nucleic acid targets using labeled complementary probes.
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.

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siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.

Effectiveness

Antimicrobial Pharmacodynamics Ascertain the effectiveness of an antimicrobial compound and test levels of antibiotic resistance against specific bacterial pathogens.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.

Human Biological Samples

Cell Line and Cellular Services Promotion for Cells and Cell lines
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...

In Vitro ADME

Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.

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Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.

In Vitro Pharmacology

Cellular Thermal Shift Assay Use a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
Target Identification Identify the target(s) of a biologically active substance.

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Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Model Development

Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Nanotechnology

Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.

Oncology Models

Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Protein Sciences

Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
PEG Protein Conjugation Improve the therapeutic or pharmacokinetic properties of a protein by pegylation.
Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.

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Phage Display Use in vitro screening method to identify protein binding partners.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.
Yeast Two Hybrid Search novel interactions or confirm hypothesized protein-protein interactions using pairwise assays.

Safety Pharmacology

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Repeat Dose Neurotoxicity Study - Other Species Conduct a repeat dose study in other species to determine the neurotoxicity of your compound.
Repeat Dose Neurotoxicity Study - Rat Conduct a repeat dose study in rats to determine the neurotoxicity of your compound.

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.

Other services

New Request

Service areas:

Biology Chemistry DMPK Pharmacology Toxicology Clinical

United States SHIRLEY 1 site

Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world. Creative Biolabs was founded by scientists who are dedicated to the conquering of cancer. We believe to build up...

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Creative Biolabs was founded by scientists who are dedicated to the conquering of cancer. We believe to build up a custom-service-centered business model is important for optimizing the drug development process, leveraging accessible resources, and forming a team of various background to conduct drug discovery in future. Our commitment to this long-term goal motivates us to deliver the highest quality results to our clients with speed.

We provide services in:

Protein services, such as PEGylation and protein directed evolution
Antibody production services, including custom labeling
Immunoassays, including ELISAs
Tissue Arrays
Antibody Engineering, featuring our Bio-fishing platform for phage display

Website: www.creative-biolabs.com

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