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QIMR Berghofer Medical Research Institute

QIMR Berghofer Medical Research Institute is listed as an academic core research supplier in the Scientist.com network, with 1 site in 1 country.

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Type of company: Academic core

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Immunodetection Use antibodies to identify a protein or antigen.

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
In-vivo Fluorescence In-vivo fluorescence enables visualisation and the study of biological processes in live organisms by using fluorescent markers.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.

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Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Spatial Metabolomics The study of the spatial distribution and localization of metabolites within biological tissues using advanced imaging and analytical techniques.

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Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
H & E Services For requesting services related to H&E Services

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Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Resin-based Histology Perform sectioning and histological analysis of epoxy/acrylic/polycarbonate-embedded samples.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
STR Profiling - Microsatellite Short Tandem Repeat Confirm cell line identity and detect cross-contamination.

Chemical and Compound Testing

Product Testing Ensure product quality standards are met.

Chemistry, Manufacturing and Controls (CMC)

Fill and Finish Processing Confirm final product sterility, formulation and packaging in the biopharmaceutical process.

Clinical Trials

Clinical Trial Design Develop study-related protocols, case report forms (CRFs) and database tools for records management.
Human Challenge Trials (CHIM) Human Challenge Trials (CHIM) are research studies where volunteers are deliberately exposed to a pathogen under controlled conditions to study the effects and potential treatments or vaccines.
Statistical Analysis Planning Technical and detailed elaboration of the principal features of the analysis described in the protocol, and includes detailed procedures for executing the statistical analysis of the primary and secondary variables...

Data Science/Bioinformatics

Clinical Biomarker Analysis An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Translational Machine Learning/AI Complex analytical approaches to find patterns and make predictions in drug discovery projects.

Disease Models

Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Cognition Models Measure therapeutic endpoints in animal models of cognition.

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Endometriosis Models Measure therapeutic endpoints in animal models of endometriosis.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.
Hepatitis C Virus Models Measure therapeutic endpoints in animal models of Hepatitis C virus infection.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Malaria Models Measure therapeutic endpoints in animal models of malaria.
Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Plasmodium-Infected Mosquitoes Order live sporozoite-infected Anopheles stephensi mosquitoes.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
DNA Extraction Extract DNA from an original source.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
qPCR Analysis Measure the accumulation of PCR products in real time.

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RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
Spatial Transcriptomics Determine the sub-cellular localization of mRNA molecules. Use this to identify cellular heterogeneity in tissues, tumors, immune cells and the subcellular distribution of transcripts.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Farm & Livestock Solutions

Virology Virus isolation for identification of new and emerging viruses.

Human Biological Samples

Cell Line and Cellular Services Promotion for Cells and Cell lines
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human Neural Stem Cells Acquire human neural stem cells isolated from brain tissue.
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptotic Cell Staining Detect apoptotic cells in culture.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.

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Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.

In Vitro Pharmacology

Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.

In Vitro Toxicology

Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.

In Vivo Pharmacokinetics

In Vivo Immunogenicity Study An in vivo immunogenicity study evaluates a substance's ability to trigger an immune response within a living organism.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Market Access

Population Health Analytics Aggregation of patient data across multiple health information technology resources, the analysis of that data into a single, actionable patient record, and the actions through which care providers can improve both...

Model Development

3D Blood-Brain Barrier Model Use an in vitro 3D blood–brain barrier model for real-time visualization of cellular and barrier functions.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Oncology Models

CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Experimental Metastatic Models Measure therapeutic endpoints in animal models of experimental metastatic cancer.
Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Xenografts Xenografts derived from oncological samples.

Safety Pharmacology

Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Genome Data Analysis Analyze genomic DNA, RNA and protein sequence data.
Machine Learning/ AI Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)

Website: qimrb.edu.au

Australia Herston 1 site

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