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PsychoGenics

PsychoGenics is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 2 countries and 4 service areas.

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Sites 2

Countries 2

Type of company: Mid sized business

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.

Show all 16 in Biomarkers 10 more

Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Peptide Bioanalysis Analyze the structure of Peptides.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Cell Culture and Characterization

Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.

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Chemical and Compound Analysis

Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.

Chemistry, Manufacturing and Controls (CMC)

Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services

Clinical Trials

Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Data Science/Bioinformatics

Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.

Disease Models

Alzheimer's Disease Models Measure therapeutic endpoints in animal models of Alzheimer's disease.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Comparative Pharmacology Compare drug responses across species for improved reliability in translational studies.
Electroencephalogram EEG Models Record electrical activity along the scalp of animal models or human patients.

Show all 36 in Disease Models 30 more

fa/fa Zucker Diabetic Rats Use a single animal species to create one or more disease models for diabetes and obesity.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Microdialysis Models Measure the effect of drug candidates on neurotransmission in rat or mouse models.
Microsurgery in Rodents Outsource microsurgeries projects required for testing new therapies on a rodent model.
Morris Water Maze Investigate spatial learning and memory in rodents.
MPTP-Induced Parkinson’s Disease (PD) The MPTP-induced Parkinson’s disease (PD) model is a chemically induced animal model widely used in neurobiological research
Neurological Neurological Pharmacology CROs specialize in in vivo high-throughput model systems to profile pre-clinical candidates for treat...
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.

DNA & RNA

Genotyping Examine a DNA sequence to identify specific genetic varients .
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.

Drug Development

Bioinformatics Consulting Consulting Services for the science of collecting and analyzing complex biological data

Food Safety & Regulations

Dietary Exposure & Intake Assessments Estimate how much of a food chemical a population, or population sub-group, consumes.

In Vitro ADME

Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

In Vitro Pharmacology

Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Model Development

Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Oncology Models

Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Protein Sciences

ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Protein Binding Determine drug-protein binding interactions
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Safety Pharmacology

Abuse and Dependence Liability Testing Determine the abuse or dependence potential of a therapeutic.
Abuse Liability Determine the dependence potential of a therapeutic.
CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Conditioned Place Preference or Aversion Study - Mouse Conduct a study to establish the aversion or conditioned place preference and determine the motivational effect of your compound in mice.
Conditioned Place Preference or Aversion Study - Rat Conduct a study to establish the aversion or conditioned place preference and determine the motivational effect of your compound in rats.
Implanted Telemetry Study - Other Species Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in other species.

Show all 13 in Safety Pharmacology 7 more

Implanted Telemetry Study - Rat Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in rats.
Locomotor Activity Assessment Study - Rat Conduct a study to determine the psychostimulant or sedative activity or your compound in rats.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Safety Pharmacology Latin Square Study - Other Species Conduct a safety pharmacology study with a Latin square design in other species.
Seizure Liability Study - Other Species Conduct a study to determine the seizure risk of your compound in other species.
Seizure Liability Study - Rat Conduct a study to determine the seizure risk of your compound in rats.
Telemetry Use implantable or external devices to study physiological parameters in model organisms

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
Machine Learning/ AI Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)
Systems Network Analysis Analyze and visualize molecular pathways including gene regulatory, protein-protein and drug-target networks.
Systems Pharmacology Understand how drugs interact with different molecular and cellular systems within biological models.

Specialty Dosing Routes

Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Rat Conduct a repeat dose intranasal study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Rats Conduct a repeat dose intravenous infusion study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.

Other services

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Service areas:

Biology DMPK Pharmacology Toxicology

Czechia Brno 1 site
United States Paramus 1 site

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PsychoGenics has operated as a contract research organization and a drug discovery company since 1999. PsychoGenics is a leader in a high throughput in vivo drug discovery where it has developed proprietary technologies to facilitate in vivo fast throughput drug efficacy screening and lead optimization. The company also offers preclinical testing in models of inflammatory and neuropathic pain (including chemotherapy-induced and peripheral neuropathy models), affective and neurodegenerative disorders (AD, PD, ALS, MS and others), neurodevelopmental disorders (autism spectrum, Fragile X, Rett, Down Syndrome, etc.), spinal cord and traumatic brain injury, state of the art microdialysis and bioanalytics, knockout and transgenic models phenotyping, advanced routes of drug delivery and other capabilities. The synergy between our proprietary technologies and CRO business have driven the development of long term relationships with more than 120 pharmaceutical, biotechnology and not-for-profit organizations, which frequently evolve into drug discovery partnerships.

Professional associations: BioNJ
Website: www.psychogenics.com

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