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Oncodesign Services

Oncodesign Services is listed as a mid sized business research supplier in the Scientist.com network, with 6 sites in 3 countries and 3 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 6

Countries 3

Type of company: Mid sized business

Agricultural Sciences Research & Development

Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties

Antibodies

AlphaLISA Quantification of analytes with high sensitivity, wider dynamic range and no wash steps involved.
Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.

Show all 12 in Antibodies 6 more

Antibody Therapy Efficacy In vivo assessment of monoclonal/bispecific antibody efficacy in a humanized mouse
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Immunodetection Use antibodies to identify a protein or antigen.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
SARS-CoV-2 (COVID-19) Antibodies Search for available SARS-COV-2 antibodies

Bioimaging

Ab-Targeted Positron Emission Tomography Visualize sites of HIV replication that are difficult to access by tissue biopsies.
Bioimaging Visualize biological process non-invasively in real time.
Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
In Vivo Positron Emission Tomography (PET) Imaging Image tumor progression or conduct biodistribution investigations in experimental animals injected with a radiolabeled molecular probe.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.

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In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.
In-vivo Fluorescence In-vivo fluorescence enables visualisation and the study of biological processes in live organisms by using fluorescent markers.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Magnetic 3D Bioprinting Fabricate spheroids representative of native cellular environments and easy to handle.
Magnetic Resonance Imaging Use MRI to obtain chemical and physical information about molecules and map the internal structure of an object.
Medical Imaging Visualize and analyze internal structures in animal models or patients.
Positron Emission Tomography (PET) Imaging Use PET imaging with radioactive agent to visualize and measure metabolic processes in the body.
SPECT-CT and PET-CT Imaging Get images that combine the spatial context of metabolic or biochemical activity with an anatomic image.
Ultrasonography diagnostic imaging technique, or therapeutic application of ultrasound.

Show all 651 services 638 more

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.

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Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
HCS Assay Development Requesting services related to HCS assay development.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Peptide Bioanalysis Analyze the structure of Peptides.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
TUNEL Assay Detect in situ DNA fragmentation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.

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Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Custom 3D Microtissue Development Convert cell lines into highly functional 3D microtissues using scaffold-free self-assembly.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Lipofection Transfection of DNA/RNA using lipofection reagents to create lipoplexes.
Microsatellite Instability Analysis Compare allelic profiles and detect genomic instability.
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
STR Profiling - Microsatellite Short Tandem Repeat Confirm cell line identity and detect cross-contamination.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.
Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.
Yeast Cell Culture Grow yeast strains or species.

Chemical and Compound Analysis

Accelerator Mass Spectrometry Detect trace levels of naturally-occurring radionuclides and stable nuclides.
Adsorption/Desorption Studies Obtain data on groundwater risk assessment.
Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Centrifugal Precipitation Chromatography Separate analytes based on their solubility in ammonium sulfate solution.

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Chemical Stability Measure the stability of small molecules in solution.
Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Computed Tomography Visualize the internal features of solid objects.
Denaturing High Performance Liquid Chromatography Separate mixtures of denatured and reannealed oligos to identify single nucleotide substitutions, deletions and insertions.
Diffuse Wave Spectroscopy Evaluate the micro-rheological properties of particles in opaque and concentrated media.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Dynamic Mechanical Analysis Measure mechanical properties of solids and polymer melts as a function of time, temperature and frequency.
Electron Diffraction Measurement (microED) Use electron diffraction patterns to characterize the crystallographic properties of a sample.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Energy Dispersive X-ray Spectroscopy Identify and estimate the elemental composition of a sample based on x-ray emission patterns.
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
Field Desorption Mass Spectrometry Use high potential fields to detect intact molecular ions of an analyte.
Filler Content Analysis Evaluate filler material to optimize product performance and process conditions.
Focused Ion Beam Apply a highly focused beam of gallium ions to remove material at high spatial resolution.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Ion Exchange Chromatography Separate and detect analytes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
Low Energy X-ray Emission Spectrometry (LEXES) Use a low energy electron beam to selectively analyze elements at or near a sample surface.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
Nano-High Performance Liquid Chromatography Separate and detect low levels of analytes.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Tomographic Imaging Use multiply-scattered light to reconstruct images of illuminated objects.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Phase Contrast X-Ray Imaging Visualize dense and intricate samples with high spatial three-dimensional resolution.
Photostability Measure drug degradation rates after exposure to various light sources.
Physicochemical Analysis Physicochemical Analysis of material or preparation evaluating (e.g.) particle size, composition, or compound structure.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.
Protein Melting Point Analysis Assess protein stability by Differential Scanning Calorimetry (DSC) or Fluorimetry (Thermofluor) methods.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Raman Spectroscopy Use spectroscopic technique to observe vibrational, rotational and other low-frequency modes in a system.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Small Angle X-Ray Scattering Obtain low-resolution structures of biopolymers in solution using an x-ray beam.
Solid State Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solid samples.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Solution Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solution samples.
Static Light Scattering Use scattered light intensity to determine the average molecular weight of biopolymers.
Structural Chemistry Examine the relationship between protein structure and function.
Structural Elucidation Determine chemical structure of a compound. Characterization techniques include mass spectrometry, infrared spectroscopy and X-ray crystallography.
Structural Spectroscopy Assess conformational transitions that proteins undergo in response to changes in their environment.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.
Total Reflections X-Ray Fluorescence Analyze liquid or smooth solid surfaces to detect ultra-trace levels of particles, residues and impurities.
Viscosity Testing Evaluate the fluid flow properties of liquids for product evaluation and quality control.
X-Ray Fluorescence (XRF) Identify and quantify the elemental composition of solid and liquid samples.
X-ray Photoelectron Spectroscopy (XPS) Analyze the surface composition and chemistry of ultra-thin layers of a sample.

Chemistry, Manufacturing and Controls (CMC)

Crystallization studies Crystallization studies
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Formulation Services Assistance when determining the look, texture, fragrance of a product with compatibility with product packaging, knowledge of competitive performance traits and product shelf life.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Subcellular Fraction Test System Obtain human, minipig, mouse, or rat dermal microsomes as in-stock standard test systems for the development of safer topical and transdermal products.
Thermo Scientific iCAP Q ICP-MS Expand your analytical capabilities with this complete trace elemental analysis solution for your high-throughput lab.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.

Clinical Trials

Nutraceuticals Clinical Research Trials Conduct clinical trials to test the efficacy and safety of nutraceuticals.
Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Companion Diagnostics

Cervical Cancer CDx Design and validate companion diagnostics for cervical cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Osteoarthritis CDx Design and validate companion diagnostics for osteoarthritis that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Pancreatic Cancer CDx Design and validate companion diagnostics for pancreatic cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

Data Science/Bioinformatics

Discovery Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data for its users.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.

Discovery Chemistry

Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.

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DNA Encoded Library (DEL) capabilities The rapid screening of vast chemical libraries by encoding millions of small molecules with unique DNA sequences, facilitating the identification of potential drug candidates.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Time of Flight Mass Cytometry (CyTOF™) Detect and quantify up to 34 different proteins simultaneously on a single-cell level.
Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
UV and IR Profiling Analyze the integrity of a compound or large biomolecule.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.

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Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Bone Models Measure therapeutic endpoints in animal models of bone disorders.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Endometriosis Models Measure therapeutic endpoints in animal models of endometriosis.
Fecal Microbiota Transplantation (FMT) - Mouse Use germ-free mice to evaluate the properties of complex or defined gut microbiota following fecal microbiota transplantation (FMT). Axenic (germ-free) mice transplanted with donor microbiota can be utilized to assess...
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Microbiome-Based Skin Disease Technology Modify the skin microbiome and deliver therapeutic proteins to the target.
Microsurgery in Rodents Outsource microsurgeries projects required for testing new therapies on a rodent model.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Amplicon - HLA Typing Use an amplicon sequencing method to identify allelic variation within the HLA genes.
Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
De Novo Transcriptome Sequencing Identify new genes without the need for a reference genome sequence.

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Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Extraction Extract DNA from an original source.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
Metagenomic Sequencing Sequence genetic material recovered directly from environmental samples
Methylation Specific PCR Determine the methylation status of a CpG site without the need for base-specific endonucleases.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Non-Bisulfite DNA Methylation Analysis Analyze DNA methylation by methods such as differential enzymatic cleavage or affinity capture
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
Poly (A) tail Length Profiling (PAL-Seq) Conduct high-throughput sequencing of individual mRNA poly (A) tails.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
RNAi Pathway Analysis Use high-throughput RNAi genetic screens to elucidate relevant signaling pathways.
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Effectiveness

In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

Farm & Livestock Solutions

Virology Virus isolation for identification of new and emerging viruses.

General in vivo Toxicology

Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
Effective Dose (ED), 50% Toxicity Test Quantify the diluted toxin needed to induce sub-lethal effects upon constant exposure in half of test organisms.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Nonclinical Study Management Provide nonclinical study management services to pharmaceutical and biotech companies. The services can be customized to meet the clients needs.
Nonclinical Study Monitoring Provide nonclinical study monitors throughout the US and Canada to monitor in vivo and in vitro studies are CROs

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Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Dog / Canine Conduct a repeat dose study in dogs to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Monkey / Non-human Primate Conduct a repeat dose study in monkey/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Other Species Conduct a repeat dose study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Short-Term Toxicity Tests Acquire preliminary data about the concentrations, exposure duration and effects of a toxin on organisms.
Single Dose Acute Toxicity Study - Dog / Canine Conduct a single dose study in Dogs and Canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Monkey / Non-human Primate Conduct a single dose study in Monkeys and Non-human Primates to determine the toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Custom FFPE cell line blocks Custom IHC compatible FFPE cell line blocks and sections
Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
HBS Asthma For requesting HBS Asthma.
HBS Autoimmune Diseases For requesting Autoimmune Diseases HBS.
HBS NASH For requesting HBS NASH

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Human 3D cultures Provision of 3D culture of Human Primary Cells
Human Biopsy Cell Models Request human biopsy cell models.
Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.

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CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
Human Blood Brain Barrier on a Chip (BBBoC) Create a blood–brain barrier multicellular model to test drug delivery to the brain.
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
3Screen™ 3D In Vitro Services 3Screen™ Platform enables complete 3D cell culture characterization.
Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.

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Assay Development Construct or create new assays or modify existing ones.
Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
ELISpot Assay and Testing Detect low levels of antigens.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Epigenetic Profiling In Vitro Assays Test for epigenetic modifications and indicator levels via in vitro assays.
Glucose Release Assay Determine free glucose levels in biological samples.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
ImmunoSEQ Assay Unmask the identity of millions of T- and B-cell receptors in a single sample using bias-controlled multiplex PCR amplification, high-throughput sequencing, and sophisticated bioinformatics.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro CAR-T Therapy Chimeric Antigen Receptor T-cell therapy: specialized form of immunotherapy
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Microbiology Study microbes and their role in human health.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Pathogen Assays Detect and distinguish viral, bacteria and fungal strains and species.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
SARS-CoV-2 (COVID-19) Assays Search for Available SARS-CoV-2 Assays
Serine Protease Assay Detect apoptosis by measuring protease activity.
Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.
Viral Clearance Assays Measure the capacity to remove or inactivate infectious agents during the manufacturing process.
Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
ATP Competitive Study Determine whether or not a compound is competitive with ATP.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Cellular Thermal Shift Assay Use a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.

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Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.
Human BCL Assays Use biochemical, cell-based or in vivo assays to measure BCL activity.
Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Mutant B-Raf Assays Use biochemical, cell based or in vivo assays to measure mutant B-Raf enzyme activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Nucleoside Transporter Assays Use biochemical, cell-based or in vivo assays to measure nucleoside transporter activity.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
Reversibility Study Determine whether or not a compound inhibits an enzyme reversibly.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
Substrate Competitive Study Determine whether or not a compound is competitive with a substrate.
Target Characterization Characterize potential drug targets during the drug discovery process.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
CH50 Assays Measure the functional activity of the classical complement activation pathway in serum or other fluid samples.
Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.

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Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Short Time Exposure (STE) Test Use in vitro eye irritation tests to assess cytotoxicity in SIRC cells (rabbit corneal cell line).
Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine Conduct a bile duct cannulation (BDC) study in dogs/canines to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
In Vivo Radiolabeled Metabolism Determine the qualitative and quantitative metabolism and/or degradation of an active ingredient in animals.
Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Minipig Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in minipigs.

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Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Mass Balance Study - Other Species Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in other species.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Milk Secretion Study - Rat Conduct a study to determine the extent of milk secretion of your radioactive compound in rats.
Ocular Distribution Study - Dog / Canine Conduct a study to determine the distribution of your compound in ocular tissues of the dog/canine.
Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Ocular Distribution Study - Other Species Conduct a study to determine the distribution of your compound in ocular tissues of other species.
Ocular Distribution Study - Rabbit Conduct a study to determine the distribution of your compound in ocular tissues of the rabbit.
Ocular Distribution Study - Rat Conduct a study to determine the distribution of your compound in ocular tissues of the rat.
Placental Transfer Study - Rat Conduct a study to determine the extent of placental transfer in rats by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Qualitative Whole Body Autoradiography Request information or a price quote for Qualitative WBA services
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
Quantitative Whole Body Autoradiography (QWBA) - Non-rodent Species Conduct a study to determine the tissue distribution of your compound radiolabeled compound in non-rodent species.
Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Mouse Efficacy Monotherapy Use mouse models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

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Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
Disease Model Database For sourcing disease models.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
NMRI Mouse Use a single animal species to create one or more disease models for cachexia and hemophilia.

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Non-Human Primate Models Use a single animal species to create one or more disease models.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
Pre-clinical Animal Surgery Conduct surgey in animals used as pre-clinical models.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Nanotechnology

Drug Delivery Technology Create microstructures that enhance drug metabolism properties.
Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.
Nanoparticle Conjugation and Functionalization Modify biomolecules to enhance structure and function.

Non-Human Biospecimen

Mouse Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rat Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Animal Hypoxia Models Measure therapeutic endpoints in hypoxic animal models.
Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Digestive System PDX Patient derived xenografts relating to organs and components of the digestive system. This includes, but is not limited to the Stomach, Intestines, Liver, Colon, Colorectal samples and Gastric samples.

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Endocrine System Xenograft Xenografts derived from organs and glands of the Endocrine system. This include samples from the Pituitary Gland, Thyroid, and Adrenals.
Ex-Vivo PDX Screening Ex-vivo PDX screening is used to evaluate the effectiveness of various drugs on tumor cells.
Experimental Metastatic Models Measure therapeutic endpoints in animal models of experimental metastatic cancer.
Hematological Cancer PDX Design and validate companion diagnostics for hematological cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
Pancreas Xenograft Measure therapeutic endpoints in pancreatic models of cancer.
Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Reproductive System PDX Patient derived xenografts relating to reproductive systems. This includes PDX from reproductive organs such as the Ovaries, Cervix, Breasts, Testes, Prostate, and Scrotum.
Reproductive System Xenografts Xenografts relating and derived from the reproductive systems. This includes samples from the ovaries, cervix, vulva, uterus, testes, scrotum, and prostate.
Urinary System PDX Patient Derived Xenografts relating to organs that comprise the Urinary system. This includes, but is not limited to, samples from the Kidneys, Liver, and Bladder.
Urinary System Xenografts Xenografts derived from organs of the Urinary system. This includes, but is not limited to, xenografts from the Bladder, Kidney, and Urethra.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.
Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Tumorigenicity Testing Test tumor-forming properties of cell products.
Viral Testing Characterize viral products for functional activity and possible contamination.

Pharmacology

In Vivo Pharmacology Study the effects of drug candidates in animal models

Pharmacovigilance

Adverse Event (AE) and Serious Adverse Event (SAE) Reporting Report unfavourable and unintended events (e.g.: abnormal laboratory results, symptoms or disease associated with treatments) to regulatory bodies via the FDA's Adverse Event Reporting System (FAERS) or other...

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.

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Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Integrated Protein Production Package Process an entire Protein Production Pipeline Project including: Gene/Oligo Synthesis, Cloning/Subcloning, Protein Expression, Protein Purification, Protein Analysis, and Protein Products from our bundle of suppliers
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
NMR Determine molecular and protein structure, and validate sample integrity.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein mapping Interrogate the entire sequence of a protein.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
SILAC Enable incorporation of isotopic labels in proteins for mass spectrometry-based quantitative proteomics.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Radioanalysis

Stand-alone Radioanalysis of Animal Pre-clinical Samples Conduct analysis of radioactive samples from preclinical radiolabeled studies.

REACH Services

Ex Vivo REACH Assays Perform testing on cells or tissues cultured directly from a test organism
OECD 452: Chronic Toxicity Studies Evaluate the direct and indirect impact of prolonged and repeated toxin exposure to test organisms.

Safety Pharmacology

Cytokine Release Syndrome In Vivo assessment of cytokine release syndrome liability in a humanized mouse
Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Respiratory Toxicology Assess difficulty breathing, altered respiration, blood gas changes and blood pH issues due to adverse reactions.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Cloud Computing Request on-demand computer resources specifically relating to large data storage and computing power.
Data Infrastructure Design and deploy an information management solution suited to users' specific needs.
LIM/eLab Notebook Services LIM/eLab Notebook Services
Microbiome Data Analysis Determine the population composition of a microbial community and analyze its contribution to human or animal health.
Scientific Pipeline Implementation Design, develop and deploy data analyses workflows.

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Software Tools Software tool for statistical analysis, data mining, genome annotation or NGS data analysis.
System Development Plan, create and deploy an information system.

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Intrathecal/Intraspinal Toxicology Conduct a study to determine the toxicity and toxicokinetic behavior of your compound when delivered via the intrathecal space.
Lethal Dose (LD), 50% Toxicity Test Measure acute toxicity by identifying the amount of pure toxin required to kill half of the experimental subjects.
Repeat Dose Inhalation Study - Other Species Conduct a repeat dose inhalation study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Inhalation Study - Rat Conduct a repeat dose inhalation study in rats to determine the toxicity and toxicokinetic behavior of your compound.

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Repeat Dose Intranasal Study - Dog / Canine Conduct a repeat dose intranasal study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Monkey / Non-human Primate Conduct a repeat dose intranasal study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Other Species Conduct a repeat dose intranasal study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Rat Conduct a repeat dose intranasal study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Dog / Canine Conduct a repeat dose intravenous infusion study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Monkey / Non-human Primate Conduct a repeat dose intravenous infusion study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Other Species Conduct a repeat dose intravenous infusion study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Rats Conduct a repeat dose intravenous infusion study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Inhalation Study - Other Species Conduct a single dose inhalation study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Inhalation Study - Rat Conduct a single dose inhalation study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Dog / Canine Conduct a single dose intranasal study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Other Species Conduct a single dose intranasal study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Dog / Canine Conduct a single dose intravenous infusion study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Other Species Conduct a single dose intravenous infusion study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Rats Conduct a single dose intravenous infusion study in rats to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to dogs/canines.
Topical Dermal Toxicity and/or Toxicokinetic Study - Minipig Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to minipigs.
Topical Dermal Toxicity and/or Toxicokinetic Study - Monkeys/Non-human Primates Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to monkeys/non-human primates.
Topical Dermal Toxicity and/or Toxicokinetic Study - Mouse Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to mice.
Topical Dermal Toxicity and/or Toxicokinetic Study - Other Species Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to other species.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rabbit Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rabbits.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rat Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rats.

Target Animal and Human Food Safety

Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
OECD 439: Skin Irritation Test (SIT) Reconstructed Human Epidermis Test (RhE) Method - An in vitro testing method designed to identify chemicals and/or mixtures capable of inducing moderate skin irritation.
Tolerance Test Under Dermatologic Control Evaluate the acceptability and skin tolerance of a cosmetic product.
Trans-Epidermal Water Loss (TEWL) Use a sensing electrode encased in a chimney to measure the relative humidity percentage at the skin surface.

Other services

Human Dendritic Cell (hDC) Model Test and validate the immune-modulating compounds in DC immune pathway models.
Labskin - 3D Skin Model Obtain a full-thickness human skin model.
New Request

Service areas:

Pharmacology Oncology Preclinical Models

France Dijon, Fontenay-aux-Roses cedex, Villebon-sur-Yvette 4 sites
Netherlands Leiden 1 site
United States New York 1 site

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Founded in 1995 and headed by Dr. Philippe Genne, *Oncodesign®* is a pioneer in preclinical assessment of anti-cancer therapy, a market that it has led for many years. Oncodesign's mission consists of discovering effective anti-cancer therapies. Its scientific expertise in pharmacology, imaging and medicinal chemistry, in addition to strong project management skills, support its two strategic activities of experimentation and discovery conducted in partnership with pharmaceutical and biotechnology companies. The experimentation activity is organized in three technological platforms: * *PREDICT®* specializes in conventional _in vitro_ and _in vivo_ pharmacology * *Chi-Mice®* focuses on the development of _in vivo_ chimeric patient-derived models * *Pharmimage®* is dedicated to multi-modal, non-invasive pharmaco-imaging. * *ONCOFLORA* offers better understanding of gut microbiota for cancer therapeutics and nutritional diets * *ONCOCARDIO* assess cardiotoxicity of anticancer drugs _in vitro_, _ex vivo_, and _in vivo_ On the basis of these three platforms, Oncodesign markets a broad range of products and services (fee for service), for the assessment, validation, targeting and diagnostic linking of anticancer therapies (small molecules, natural products, antibodies, gene therapy, vaccination, hormone therapy, radiotherapy, etc.). Using our three platforms and our team of experts, we offer services in: * *Xenograft models* - Orthotopic, metastatic, patient-derived, skingraft * *Imaging* - Pharmaco-imaging, MRI, PET CT, SPECT, biodistribution * *In vitro testing* - cell lines, ADCC/CDC h3. We're Here to Help!
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Professional associations: AAPS
Website: www.oncodesign-services.com

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