Supplier site
Group of sites (click to zoom)

Scientist.com supplier network (site locations)

Research supplier

WuXi AppTec

WuXi AppTec is listed as a large business research supplier in the Scientist.com network, with 21 sites in 2 countries and 1 service area.

View WuXi AppTec on Scientist.com

Email me this page as a PDF

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 21

Countries 2

Logo WuXi AppTec, via Wikimedia Commons, Public domain. Shown to identify the organization; it may be a registered trademark.

Type of company: Large business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.

Show all 14 in Antibodies 8 more

In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Integrated Antibody Development Package-US Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
OmniRat Transgenic Animal Platform Produce humanized antibodies using a transgenic rat platform.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Recombinant Antibody Production Request services related to antibody production services.

Bioimaging

Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
In Vivo Positron Emission Tomography (PET) Imaging Image tumor progression or conduct biodistribution investigations in experimental animals injected with a radiolabeled molecular probe.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
Mass Spectrometry Imaging Visualize the spatial distribution of molecules, as biomarkers, metabolites, peptides or proteins by their molecular masses
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Show all 8 in Bioimaging 2 more

Positron Emission Tomography (PET) Imaging Use PET imaging with radioactive agent to visualize and measure metabolic processes in the body.
Scanning Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.

Show all 447 services 435 more

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.

Show all 28 in Biomarkers 22 more

Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Genomics Genomic services including applications to DNA (*sanger sequencing, whole genome amplification, library screening, cloning, sub-cloning, and DNA isolation*) and RNA (*microRNA analysis, RNA isolation, qRT-PCR, mRNA...
HCS Assay Development Requesting services related to HCS assay development.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.

Show all 13 in Cell Culture and Characterization 7 more

Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
cGMP Cell Banking Request information or a price quote for cGMP Cell Banking services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Stem Cell Methodologies Study Stem Cell characteristics.

Chemical and Compound Analysis

Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Fluorescence Mediated Tomography Visualize the spatial distribution of fluorescencently labeled probes and substances.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.

Show all 14 in Chemical and Compound Analysis 8 more

GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Ion Exchange Chromatography Separate and detect analytes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemical and Compound Testing

Batch Release Request information or a price quote for Batch Release services
Clinical Urinalysis Analyze protein loss and kidney dysfunction and run urine chemistry panels.

Chemistry, Manufacturing and Controls (CMC)

API and Drug Product Stability Testing API and Drug Product Stability Testing.
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
Bulk Raw Materials Acquire raw materials in large volumes at wholesale pricing.
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.

Show all 13 in Chemistry, Manufacturing and Controls (CMC) 7 more

Drug product packaging and labeling Drug product packaging and labelling
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Fill and Finish Processing Confirm final product sterility, formulation and packaging in the biopharmaceutical process.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Milling, grinding, spray-drying Milling, grinding, spray-drying
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Tablet Manufacturing Use automatic or semi-automatic machinery to create various standard and non-standard tablets.

Clinical Consulting

PK PD Modeling & Analysis Examine the relationship between drug metabolism and therapeutic efficacy.

Discovery Chemistry

Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Chiral Synthesis Synthesize a compound by a method that favors formation of a specific enantiomer or diastereomer.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Finding Service Enter the compound name, CAS # or SMILES string in the box below or upload an Excel, Word or SD file with a list of compounds.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.

Show all 23 in Discovery Chemistry 17 more

Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Leachable and extractable testing Leachable and extractable testing
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.

Show all 77 in Disease Models 71 more

Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Bone Models Measure therapeutic endpoints in animal models of bone disorders.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Cartilage Repair Models Measure therapeutic endpoints in animal models of cartilage repair.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Cough Models Test the therapeutic efficacy of drug candidates in cough models.
Cyp2f2 Knockout Mouse Study Cyp2f2-mediated lung metabolism.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
Electroencephalogram EEG Models Record electrical activity along the scalp of animal models or human patients.
Emesis Models Measure therapeutic endpoints in animal models of emesis.
Excitotoxicity Models Measure therapeutic endpoints in animal models with excitotoxic pathology.
Eye Pain Models Measure therapeutic endpoints in animal models of eye pain.
Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.
Hepatitis C Virus Models Measure therapeutic endpoints in animal models of Hepatitis C virus infection.
IGA Glomerulonephritis Models Measure therapeutic endpoints in animal models of IgA glomerulonephritis.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Influenza Models Measure therapeutic endpoints in animal models of influenza.
Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
Kidney Transplant Models Measure therapeutic endpoints in kidney transplant models.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Malaria Models Measure therapeutic endpoints in animal models of malaria.
Microdialysis Models Measure the effect of drug candidates on neurotransmission in rat or mouse models.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Obese Primates Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Obstructive Sleep Apnea Rat Study pathologic cardiac changes of obstructive sleep apnea (OSA) in a rat model.
Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
Osteoporosis Models Measure therapeutic endpoints in animal models of osteoporosis.
Otitis Media Models Measure therapeutic endpoints in animal models of otitis media.
Otology Models Measure vertigo, tinnitus, otitis media and hearing loss in animal models.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
Tinnitus Models Measure therapeutic endpoints in animal models of tinnitus.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
ddPCR-Based Plasma Genotyping Perform noninvasive tumor genotyping.
De Novo Genome Sequencing Determine the DNA sequence of uncharacterized genomes.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.

Show all 37 in DNA & RNA 31 more

DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RAD Sequencing Examine a small percentage of the target genome.
Restriction Fragment Length Polymorphism Identification Uses gel electrophoresis to identify differences in restriction fragment lengths produced by enzymatic digestion of DNA.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
RNAscope In Situ Assays Profile single-cell gene expression in situ.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Targeted Sequencing/Resequencing Detect variations in a genome subset.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Whole Genome Amplification (WGA) Amplify an entire genome from a single cell.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.

General in vivo Toxicology

Carcinogenicity Study - Mouse Conduct a repeat dose, chronic carcinogenicity study in mice to determine the tendency of your compound to produce tumors.
Carcinogenicity Study - Rat Conduct a repeat dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dose Range Finding Study - Dog /Canine Conduct a study to determine the dose range of your compound in dogs/canines.
Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Show all 11 in General in vivo Toxicology 5 more

IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Repeat Dose Toxicity Study - Dog / Canine Conduct a repeat dose study in dogs to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

In Vitro ADME

Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.

Show all 17 in In Vitro ADME 11 more

HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.

Show all 17 in In Vitro Assays 11 more

ELISpot Assay and Testing Detect low levels of antigens.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Microbiology Study microbes and their role in human health.
Pathogen Assays Detect and distinguish viral, bacteria and fungal strains and species.
Viral Clearance Assays Measure the capacity to remove or inactivate infectious agents during the manufacturing process.

In Vitro Pharmacology

ATP Competitive Study Determine whether or not a compound is competitive with ATP.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Cellular Thermal Shift Assay Use a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.

Show all 53 in In Vitro Pharmacology 47 more

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.
Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.
In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Target Characterization Characterize potential drug targets during the drug discovery process.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
Mouse Lymphoma Assay Assay for DNA damage in cells exposed to test substances.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.

Show all 12 in In Vivo Pharmacokinetics 6 more

Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
C57BL/6 Mouse Use a single animal species to create one or more disease models for cancer stem cell tumors, hemophilia and leukemia.
Custom Model Development Develop a custom disease model.
Fresh Functional Human Tissue Safety Assays Use fresh functional human tissue to assess pre-clinical safety of test compounds.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.

Show all 17 in Model Development 11 more

Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
Non-Human Primate Models Use a single animal species to create one or more disease models.
PiggyBac Transgenic Mouse Service Obtain single-copy transgenic embryos with consistent expression of any desired transgene.
Pseudopregnant CD1 Mouse Use a single animal species to create gene-modified mouse models.
Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Neurotoxicology

Single Dose Acute Neurotoxicity Study - Other Species Conduct a single dose study in other species to determine the neurotoxicty of your compound.
Single Dose Acute Neurotoxicity Study - Rat Conduct a single dose study in rats to determine the neurotoxicty of your compound.

Non-Human Biospecimen

Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Animal Hypoxia Models Measure therapeutic endpoints in hypoxic animal models.
Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
Lung PDX Measure therapeutic endpoints in patient-derived xenografts of pulmonary cancer.
Murine Adenocarcinoma 16 (MAC16) Murine Test for therapeutic efficacy of drug candidates in muscle wasting models.

Show all 12 in Oncology Models 6 more

NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Product Orders

BioTx General Biotherapeutics analyze therapeutics and drugs via biological means and recombinant DNA. Pre-clinical sample bioanalysis and le...
Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.

Show all 36 in Protein Sciences 30 more

Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Lentivirus Production Develop lentiviruses and production protocols.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
NMR Determine molecular and protein structure, and validate sample integrity.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Phage Display Use in vitro screening method to identify protein binding partners.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Engineering Alter the features or properties of a protein for a specific purpose.
Protein Expression In Plant Cells Express recombinant proteins in plant cells.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein mapping Interrogate the entire sequence of a protein.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Services Protein analysis and tagging are key steps in understanding the effects of compounds and treatments on your target disease outc...
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Radioanalysis

Stand-alone Radioanalysis of Animal Pre-clinical Samples Conduct analysis of radioactive samples from preclinical radiolabeled studies.

REACH Services

OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.

Safety Pharmacology

CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Cytokine Release Syndrome In Vivo assessment of cytokine release syndrome liability in a humanized mouse
Endocrine Disruptor Screening Use biochemical, cell based or in vivo assays to identify and quantify endocrine-modulating agents.
Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Jacketed External Telemetry (JET) Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Locomotor Activity Assessment Study - Rat Conduct a study to determine the psychostimulant or sedative activity or your compound in rats.

Show all 13 in Safety Pharmacology 7 more

Microelectrode Array Neurotoxicity Assays Use microelectrode array to measure neurotoxicity-related activities.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Repeat Dose Neurotoxicity Study - Other Species Conduct a repeat dose study in other species to determine the neurotoxicity of your compound.
Repeat Dose Neurotoxicity Study - Rat Conduct a repeat dose study in rats to determine the neurotoxicity of your compound.
Respiratory Toxicology Assess difficulty breathing, altered respiration, blood gas changes and blood pH issues due to adverse reactions.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.

Specialty Dosing Routes

Single Dose Acute Intranasal Study - Dog / Canine Conduct a single dose intranasal study in dogs/canines to determine the toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Other services

Natural Product Fermentation Produce large amounts of natural products.
New Request  
New Supplier Request Please provide supplier contact details below. Note: to ensure efficient on-boarding and track progress, you will be added in our initial communication to the supplier.

Service areas:

Chemistry

China Shanghai, Nantong, Wuhan, 苏州, Changzhou, Chengdu and 5 more 17 sites
United States Indianapolis, Marietta, Natick, San Diego 4 sites

WuXi AppTec is a leading global pharmaceutical, biologics, and medical device outsourcing company with operations in China and the US. We provide laboratory and manufacturing services from discovery to commercialization, helping shorten time to market and lower the cost of R&D. Our GMP and GLP facilities in China and the US (>2 million sq. ft.) are recognized by worldwide regulatory authorities (FDA, EMA, TGA, sFDA, KFDA, JMHLW and OECD). WuXi AppTec is listed (WX) on the NYSE with a market cap of >$1 billion. Chemistry With unparalleled capacity and expertise in chemistry, we offer a full...

Show the full description

Our GMP and GLP facilities in China and the US (>2 million sq. ft.) are recognized by worldwide regulatory authorities (FDA, EMA, TGA, sFDA, KFDA, JMHLW and OECD).
WuXi AppTec is listed (WX) on the NYSE with a market cap of >$1 billion.

Chemistry
With unparalleled capacity and expertise in chemistry, we offer a full range of services from synthetic chemistry to chiral separations, from small molecule synthesis to peptide and peptidomimetics, from nucleoside to fluorinated building blocks, from milligram preparation to kilogram GLP scale-up, from reagent service to compound management, all led by experts of their respective fields.

We provide services in:

Synthetic Chemistry - custom synthesis, library design, fluorine chemistry, nucleosides
Analytical Chemistry - impurity analysis, physicochemical property, method development
Chiral Separation and Large-Scale Purification
Peptide Synthesis
Catalog Reagents - templates, reagent service, natural products
Compound Management

Biopharmaceutical Testing
GLP/GMP-compliant testing services for biologics. include cell line characterization, viral clearance validation, lot release, & stability studies.

Pharmaceutical Discovery & Development
Fully integrated discovery and development programs including chemistry, biology, ADME, DMPK, pharmacology & safety. More than 50 programs have been completed from discovery to manufacturing in as little as 2.5 years.

Toxicology
Suzhou GLP facility is the only lab in China with dual certification from OECD & sFDA. US GLP center specializes in medical devices, and gene & cell therapeutic biodistribution studies. All toxicology facilities are AAALAC accredited.

Bioanalytical
FDA-inspected laboratory in China has analyzed more than 500,000 clinical samples. Recently opened bioanalytical lab in the US.

Pharmaceutical and Biologics GMP Manufacturing
Pharmaceutical CMC services for intermediates & APIs, delivering more than 120 APIs & 160 Clinical Trial batches. GMP manufacturing is available for cell therapy & tissue-based products. More than 1,000 GMP lots have been produced.

Combination Products
Unique experience to support companies developing combination products (drug-coated stents, tissue-based products used for wound healing, etc.) requiring expertise and understanding of the regulatory requirements involving multiple regulatory agency approval(e.g., US FDA CBER/CDRH or CDER /CDRH).

Website: www.wuxiapptec.com

Work with WuXi AppTec on Scientist.com

For prices, more details, or to contact WuXi AppTec, visit Scientist.com.

View on Scientist.com