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Curia

Curia is listed as a large business research supplier in the Scientist.com network, with 7 sites in 1 country and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 7

Countries 1

Type of company: Large business

Antibodies

Immunodetection Use antibodies to identify a protein or antigen.
Recombinant Antibody Production Request services related to antibody production services.
Yeast Display Discover or optimize eukaryotic proteins and antibodies that contain post translational modifications

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.
Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.

Biomarkers

Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Cell Culture Culture primary or immortalized cell lines.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.

Show all 152 services 138 more

Chemical and Compound Analysis

Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Co Crystallization Co-crystallize drug candidates and target proteins for use in x-ray diffraction studies.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Compound Purification Purify compounds using preparative HPLC, exchange resins, filtration and crystallization.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.

Show all 23 in Chemical and Compound Analysis 17 more

Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Inductively Coupled Plasma (ICP) Analysis Characterize ultra-small levels of multiple solid analytes simultaneously.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
Natural Product Libraries Find microbial, botanical and marine sources of natural products.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Photostability Measure drug degradation rates after exposure to various light sources.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Spray Drying Convert a liquid into a powder by rapidly drying the mixture and removing the moisture component.
Structural Chemistry Examine the relationship between protein structure and function.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemical and Compound Testing

Batch Release Request information or a price quote for Batch Release services
Impact Testing Measure the ability of a material to resist high-rate loading for product safety and longevity.
Puncture Strength Testing Use compressive tests to determine the rupture properties of a material.

Chemistry, Manufacturing and Controls (CMC)

Analytical Development and Validation Request services related to Analytical Development and Validation
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Fill and Finish Processing Confirm final product sterility, formulation and packaging in the biopharmaceutical process.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.

Show all 10 in Chemistry, Manufacturing and Controls (CMC) 4 more

GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Clinical Consulting

Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.

Discovery Chemistry

Certified Standards Find certified standards for assays, tests and services.
Chiral Synthesis Synthesize a compound by a method that favors formation of a specific enantiomer or diastereomer.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.

Show all 20 in Discovery Chemistry 14 more

Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Natural Product Screening Screen large natural product collections for therapeutic activity.
Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
UV and IR Profiling Analyze the integrity of a compound or large biomolecule.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).

Show all 25 in In Vitro ADME 19 more

CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.

Show all 8 in In Vitro Assays 2 more

In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

In Vitro Pharmacology

Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.

Show all 11 in In Vitro Pharmacology 5 more

Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Other Specialty Toxicology

Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Raw Materials Testing Verify that raw materials are sterile and not contaminated by mycoplasma, virus or other microorganisms.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Product Orders

BioTx General Biotherapeutics analyze therapeutics and drugs via biological means and recombinant DNA. Pre-clinical sample bioanalysis and le...

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Lentivirus Production Develop lentiviruses and production protocols.

Show all 18 in Protein Sciences 12 more

NMR Determine molecular and protein structure, and validate sample integrity.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Protein Binding Determine drug-protein binding interactions
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Scientific Data Services

Automated Image Analysis Automated Image Analysis
Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.

Testing Services

In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Other services

Natural Product Fermentation Produce large amounts of natural products.
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Service areas:

Biology Chemistry

United States Buffalo, Albany, Hayward, Lebanon, Rensselaer, San Carlos 7 sites

For more than 20 years, Albany Molecular Research Inc. (AMRI) has provided fully integrated drug discovery, development and manufacturing services – all while adapting to the rapidly changing needs of our customers within the pharmaceutical, biotechnology and related industries. With locations in the United States, Europe and Asia, AMRI offers you a versatile and strategic way of partnering with us that is designed to deliver reduced risk, greater flexibility and a better return on investment. AMRI has successfully partnered R&D programs and is actively seeking to out-license its remaining...

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With locations in the United States, Europe and Asia, AMRI offers you a versatile and strategic way of partnering with us that is designed to deliver reduced risk, greater flexibility and a better return on investment. AMRI has successfully partnered R&D programs and is actively seeking to out-license its remaining programs for further development.

Welcome to AMRI and a whole new world of contract research, development and manufacture.

With AMRI you have full access to all our resources, including leading technologies, global facilities and a record of accountability. With AMRI, you can create a customized business model to meet your goals without the need to compromise on quality, productivity or timelines.

Choosing AMRI means you receive:

Strong intellectual input for creative customer solutions
Integrated global chemistry and biology services
Seamless technology transfer at every stage from early discovery to commercial production
Partnering and out-licensing opportunities for proprietary research programs.

Professional associations: DCAT
Website: www.curiaglobal.com

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