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Pacific Diagnostics

Pacific Diagnostics is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Small business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.

Show all 30 in Biomarkers 24 more

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Cytogenetics Examine the structure and function of the cell, especially chromosomes.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
Whole Transcriptome Amplification Amplify total RNA from a single cell.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
Microsatellite Instability Analysis Compare allelic profiles and detect genomic instability.

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Resin-based Histology Perform sectioning and histological analysis of epoxy/acrylic/polycarbonate-embedded samples.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.
Yeast Cell Culture Grow yeast strains or species.

Show all 118 services 105 more

Chemical and Compound Analysis

UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Clinical Protocol Design & Development Creation of clinical protocol document which details how a clinical trial is designed, relating to to the methodology, hypothesis, and operation of clinical trial to ensure the safety of the patients is...
Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.

Clinical Trials

Case Report Monitoring & Auditing Ensure the adequate collection and traceability of clinical data in preparation for review by the FDA.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.
Clinical Trial Design Develop study-related protocols, case report forms (CRFs) and database tools for records management.
Site Selection Select clinical trial sites with clinicians who recruit, enroll, treat and evaluate trial patients.

Data Science/Bioinformatics

Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
In Silico Nucleic Acid Microarray Analysis Use software to visualize and evaluate gene activity in response to various stimuli.

DNA & RNA

Amplicon - HLA Typing Use an amplicon sequencing method to identify allelic variation within the HLA genes.
Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
Amplified Fragment Length Polymorphism Detection Detect DNA polymorphisms based upon restriction enzyme digestion and PCR.
Bisulfite Sequencing (RRBS) Analyze genome-wide methylation profiles on a single nucleotide level.
cDNA library construction Generate a library of recombinant cDNA clones.
Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.

Show all 47 in DNA & RNA 41 more

ChIP-Sequencing Use chromosome immunoprecipitation to identify DNA-protein binding sites in a genome.
ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
De Novo Transcriptome Sequencing Identify new genes without the need for a reference genome sequence.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Extraction Extract DNA from an original source.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA-lipid interaction analysis Investigate cellular dynamics based on changes in fluorescent properties.
Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
Genotyping Examine a DNA sequence to identify specific genetic varients .
In Situ Hybridization Localize specific nucleic acid targets using labeled complementary probes.
Linear Based RNA Amplification Perform rapid non-PCR RNA amplificaton.
Metagenomic Sequencing Sequence genetic material recovered directly from environmental samples
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
Methylation Specific PCR Determine the methylation status of a CpG site without the need for base-specific endonucleases.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
mtDNA Sequencing Use next-generation sequencing (NGS) technology to detect and analyze mitochondrial mutations.
Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Restriction Fragment Length Polymorphism Identification Uses gel electrophoresis to identify differences in restriction fragment lengths produced by enzymatic digestion of DNA.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Targeted Bisulphite Sequencing Reveal changes in DNA methylation associated with nuclear reprogramming.
Targeted Sequencing/Resequencing Detect variations in a genome subset.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Amplification (WGA) Amplify an entire genome from a single cell.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

In Vitro Assays

Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Microbiology Study microbes and their role in human health.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

In Vitro Pharmacology

SELEX Select and identify highly specific aptamers with binding affinities comparable to traditional antibodies.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Market Access

Market Access Materials Find general strategies and methods used to market a pharmaceutical product or device.
Market Research & Business Intelligence Run market feasibility studies, establish customer needs, improve product performance and analyze competition.

Medical Communications

Medical Publications Make clear and accurate presentations of scientific and technical data.
Medical Writing and Editing/Manuscript Development Communicate scientific, technical and health-related information to a range of audiences.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Data and Text Mining Derive structured data from free text in order to become accessible for data-mining algorithms.
Database Integration Convert bioinformatics results from multiple data sources (DSs) into a single operational format.
Molecular Phylogenetics Analyze hereditary molecular differences in genomic sequences to compare genomes.
Software Tools Software tool for statistical analysis, data mining, genome annotation or NGS data analysis.

Other services

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Service areas:

Biology Clinical

United States Irvine, irvine 2 sites

Pacific Diagnostics offers a broad range of high-complexity diagnostic testing including oncology testing and stem cell line characterization services.

Website: www.researchdx.com

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