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R&D Systems

R&D Systems is listed as a large business research supplier in the Scientist.com network, with 1 site in 1 country and 1 service area.

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Type of company: Large business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Isotype Switching Modify antibody isotypes from any species to any human IgG isotype.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.

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Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.

Bioimaging

Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.

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Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Protein Glycosylation Mapping Technique Map glycosylation sites in proteins using liquid chromatography and mass spectrometry.
SomaScan Proteomic Assay Measure 11,000 protein measurements from a 55-µL sample.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
TUNEL Assay Detect in situ DNA fragmentation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

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Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Chromosomal Characterization Establish karyotype/chromosome profile by cytogenetic analysis of cell preparation.
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.

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Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Insect Tissue Culture Grow insect cells.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Ion Exchange Chromatography Separate and detect analytes.

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Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.

Chemistry, Manufacturing and Controls (CMC)

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.

Discovery Chemistry

Compound Purchase Buy compounds, building blocks or compound libraries.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Time of Flight Mass Cytometry (CyTOF™) Detect and quantify up to 34 different proteins simultaneously on a single-cell level.

Disease Models

Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
cDNA library construction Generate a library of recombinant cDNA clones.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Sequencing Determine the nucleotide sequence of DNA samples.

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Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.

Human Biological Samples

HBS Alzheimer's Acquire fresh, frozen, or fixed Alzheimer's tissues or other related Alzheimer's HBS.
HBS Diabetes For requesting HBS Diabetes.
HBS Huntington's For requesting HBS Huntington's.
HBS Parkinson's For requesting HBS Parkinson's
Human Bone Marrow Aspirates Acquire fresh/frozen Bone Marrow mononuclear cells based on patient demographics, disease stage, treatment and history.
Human Breast Milk Acquire fresh/frozen normal breast milk based on patient demographics and history.

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Human Cerebral Spinal Fluid (CSF) Acquire fresh/frozen normal cerebrospinal fluid based on patient demographics and history.
Human HSC's For requesting human sourced hematopoetic stem cells
Human iPSC's For requesting human sourced induced pluripotent stem cells.
Human Leukopaks Obtain enriched leukapheresis-derived products from normal peripheral blood.
Human Nasal Fluid Acquire fresh/frozen normal nasal fluid based on patient demographics and history.
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Saliva Acquire fresh/frozen normal saliva based on patient demographics and history.
Human Semen Acquire fresh/frozen normal semen based on patient demographics and history.
Human Serum Acquire fresh/frozen normal serum based on patient demographics and history.
Human Tears Acquire fresh/frozen Tears based on patient demographics, disease stage, treatment and history.
Human Urine Acquire fresh/frozen normal urine based on patient demographics and history.
Human Whole Blood Acquire fresh/frozen normal whole blood based on patient demographics and history.

In Vitro ADME

Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

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Cell Proliferation Measure cell number, cell viability and cell division.
ELISpot Assay and Testing Detect low levels of antigens.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Microbiology Study microbes and their role in human health.
Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.

In Vitro Pharmacology

High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Product Orders

Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Carbohydrate Isolation Obtain pure monosaccharides, pure polysaccharides or related derivatives from samples.
Carbohydrate Isolation Protocol Development Design and optimize protocols for carbohydrate isolation.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
Cytokines Find recombinant cytokines or cytokine assays.

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ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Native Protein Purification Purify native proteins from sources such as tissue & serum.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Other services

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Service areas:

Biology

United States Minneapolis 1 site

R&D Systems provides assays, stem cells, flow cytometry, reagents, and a variety of kits.

Website: www.rndsystems.com/services

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