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Resolian
Resolian is listed as a mid sized business research supplier in the Scientist.com network, with 3 sites in 2 countries and 5 service areas.
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Sites
3
Countries
2
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Biomarkers
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Peptide Bioanalysis Analyze the structure of Peptides.
Show all 8 in Biomarkers
- Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
- Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Chemical and Compound Analysis
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
- Inductively Coupled Plasma (ICP) Analysis Characterize ultra-small levels of multiple solid analytes simultaneously.
- Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
Show all 11 in Chemical and Compound Analysis
- Nano-High Performance Liquid Chromatography Separate and detect low levels of analytes.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
- Structural Spectroscopy Assess conformational transitions that proteins undergo in response to changes in their environment.
Show all 54 services
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
In Vitro ADME
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Show all 20 in In Vitro ADME
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Multidrug Resistance Identify potential causes of drug-drug interactions.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vitro Assays
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
In Vitro Pharmacology
- Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
- Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Model Development
- Fresh Functional Human Tissue Permeability Assays Use fresh functional human tissue to assess tissue permeability with various compounds.
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
- Protein Binding Determine drug-protein binding interactions
- Protein Sequencing Determine the amino acid sequence of protein or peptide.
REACH Services
- OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
Other services
- New Request
Service areas:
Biology
Chemistry
DMPK
Pharmacology
Toxicology
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
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United Kingdom 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Alliance Pharma is a contract research organization (CRO) that specializes in advanced bioanalytical research services for both small and large molecule drugs, as well as drug metabolism studies for pharmaceutical and biotechnology companies. Our facility is located at 17 Lee Boulevard in Malvern, PA. A selection of services that Alliance Pharma provides: Method development, validation and sample analysis Using LC-MS/MS or immunoassay PK/TK immunoassays (ELISA, ECL, MSD, Gyros) Immunogenicity assays (anti-drug antibody screening, confirmation, titer assessment, and Nab determination)...
Show the full description
Alliance Pharma is a contract research organization (CRO) that specializes in advanced bioanalytical research services for both small and large molecule drugs, as well as drug metabolism studies for pharmaceutical and biotechnology companies. Our facility is located at 17 Lee Boulevard in Malvern, PA.
A selection of services that Alliance Pharma provides:
- Method development, validation and sample analysis Using LC-MS/MS or immunoassay
- PK/TK immunoassays (ELISA, ECL, MSD, Gyros)
- Immunogenicity assays (anti-drug antibody screening, confirmation, titer assessment, and Nab determination)
- Cell-based bioassays (cytotoxicity, genotoxicity, reporter gene assays, and immunochemistry)
- Single and multiplex biomarker panels for RNAi, genotyping, gene expression, mutation, and methylation
- Drug metabolism studies
- Professional associations
- AAPS, MassBio, PABio
- Website
- www.resolian.com
Work with Resolian on Scientist.com
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