Focus Synthesis

Focus Synthesis offers exclusive contract research services based on intelligent approaches and creative solutions to address challenging projects in synthetic organic chemistry, drug discovery, drug development, intellectual property coverage and diagnostic development. We are unique in that every project we undertake is given individualized attention by Darryl Rideout, Ph.D., founder and CEO of Focus Synthesis. Our catalog molecules are designed using rational cheminformatics principles to create chemical building blocks to help you explore uncharted chemical space, expand SAR knowledge and bolster your IP position.

Focus Synthesis was founded in 2004 to address the lack of chemical diversity in early stage discovery and help pharmaceutical companies avoid late stage failure of new drug candidates. We provide drugable, rare and unique building blocks to discovery scientists, using cheminformatic-based design. Since 2004, we have grown and added a broad range of CRO services, which build upon and leverage our unique tools for drug discovery and biotechnology.

We have built our reputation on finding creative yet practical solutions to our clients’ most challenging problems. We pride ourselves on the ability to offer a steady stream of viable ideas, identifying and implementing workable alternatives to help you meet your goals.

CONTRACT RESEARCH SERVICES
Custom Synthetic Organic Chemistry
Services covering a broad range of synthetic organic methods. We excel at finding innovative, clever, practical work-arounds for problems encountered with synthetic chemistry, purification and scalability. For Drug Discovery, we will define and optimize multistep synthetic methods to yield between 1 mg to 10 g of bioactive organic molecules. For Drug Development, we will develop scalable, nontoxic synthetic methods and identify work-arounds to replace difficult-to-scale processes.

Drug Discovery
Our Drug Discovery services cover synthesis, medicinal chemistry and computer-aided drug design and discovery. For Medicinal Chemistry projects, ensure diversity and property space coverage with distinct, custom-designed building blocks. Expand leads, increase success rates and improve potency with the help of novel computational tools available ONLY from Focus Synthesis. Our synthesis services are designed to help overcome a range of commonly encountered problems related to genotoxicity, scalability, biological activity, and patentability.

Build and Strengthen Intellectual Property
Focus Synthesis offers creative design services to generate novel, patentable ligands for your target biomolecules to help strengthen and protect your intellectual property. We can improve overall range of IP coverage for your leads through exploration of uncharted regions of chemical space using rational chemoinformatics approaches. We can expand synthetic method IP through invention and significant improvement to ensure robust manufacturing IP coverage for your molecule.

Drug Development
Our chemistry services for drug development are designed to help address gaps in pre-clinical development and support advancement to clinical trials. We can synthesize deuterated analogs of your drug candidates, develop chiral synthetic approaches for both enantiomers or perform synthesis of alternate salt forms of your drug candidate made with pharmaceutically acceptable counterions to improve stability and solubility. We offer confirmation of structure to strengthen IP and bioanalysis to support pharmacokinetic studies.

Diagnostics
We will synthesize new molecules that support development of robust and patentable diagnostic assays. We can handle PEG derivatives and molecular weights up to 2000 Daltons. Our expertise includes synthesis of small molecule antigen-linker-reactive group and biotin conjugates, conjugates utilizing multiple different attachment regiochemistries and identification of alternate strategies to address unstable molecules or problems related to synthesis or biological activity.

TOOLS FOR DRUG DESIGN AND DISCOVERY
Our Catalog Molecules are designed using rational chemoinformatics principles to create chemical building blocks that help you explore uncharted chemical space, expand SAR knowledge and bolster your IP position.

TIDEA™ is a target-independent approach to prediction of small molecule drug candidate affinity.

Knowledge-enabling Building Blocks are drug discovery precursors with structures or properties that are not found in commercially-available molecules:

Rare and Unique Substructures® are building blocks and synthons designed by Focus
Synthesis to contain rare structure fragments found in very few commercially-
available molecules.

Cheminformatic Gap Fillers™ are drugable building blocks designed by Focus
Synthesis to fill specific gaps in a region of chemical property space.