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Alpha Genesis, Inc.

Alpha Genesis, Inc. is listed as a mid sized business research supplier in the Scientist.com network, with 1 site in 1 country and 1 service area.

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Type of company: Mid sized business

Animal Science and Welfare Audits

Veterinary Support Lab technician and veterinarian services providing support for model organisms and animal husbandry.
Vivarium Support Source procurement, housing, husbandry, and care of laboratory animals as well as designing, building and managing vivarium facilities.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.

Cell Culture and Characterization

Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.

Chemical and Compound Testing

Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.

Developmental and Reproductive Toxicology (DART)

Embryo-Fetal Development (EFD) Study (Segment II) Test drug candidate in Segment II toxicology services.
Enhanced Pre/Post-Natal Development Study (ePPND) - Monkey / Non-human Primate Conduct a study that combines in utero and postnatal assessments of your compound in monkeys/non-human primates.
Fertility and Embryonic Development Study (Segment I) Test drug candidate in Segment I toxicology services.
Fertility and Embryonic Development Study (Segment I) - Other Species Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in other species.
Pre/Post-Natal Development (PPND) Study (Segment III) - Other Species Conduct a study to quantify the effect of your compound on fetal development, parturition, and post-natal development in other species.
Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Show all 179 services 165 more

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.

Show all 41 in Disease Models 35 more

Cataract Models Measure therapeutic endpoints in animal models of cataracts.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Comparative Pharmacology Compare drug responses across species for improved reliability in translational studies.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.
Hepatitis C Virus Models Measure therapeutic endpoints in animal models of Hepatitis C virus infection.
In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Obese Primates Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
Ocular Inflammation Models Measure ocular inflammation in models of eye disorders such as uveitis and keratitis.
Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
Osteoporosis Models Measure therapeutic endpoints in animal models of osteoporosis.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.

Drug Development

Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

General in vivo Toxicology

Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.
Effective Dose (ED), 50% Toxicity Test Quantify the diluted toxin needed to induce sub-lethal effects upon constant exposure in half of test organisms.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.

Show all 10 in General in vivo Toxicology 4 more

Repeat Dose Toxicity Study - Monkey / Non-human Primate Conduct a repeat dose study in monkey/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Other Species Conduct a repeat dose study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Short-Term Toxicity Tests Acquire preliminary data about the concentrations, exposure duration and effects of a toxin on organisms.
Single Dose Acute Toxicity Study - Monkey / Non-human Primate Conduct a single dose study in Monkeys and Non-human Primates to determine the toxicokinetic behavior of your compound.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.

Show all 23 in In Vitro Pharmacology 17 more

Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.

In Vitro Toxicology

Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Cytotoxicity Test for effects on cell viability and proliferation
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations

Show all 8 in In Vitro Toxicology 2 more

Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.

In Vivo ADME

Chronic Bile Duct Cannulation (BDC) Study - Monkey / Non-human Primate Conduct a bile duct cannulation (BDC) study in monkeys/non-human primates to support the absorption, distribution, metabolism and excretion profiling of your compound.
Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Immunogenicity Study An in vivo immunogenicity study evaluates a substance's ability to trigger an immune response within a living organism.
In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Show all 10 in In Vivo Pharmacokinetics 4 more

Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.

Model Development

Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.
Non-Human Primate Models Use a single animal species to create one or more disease models.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.

Neurotoxicology

Single Dose Acute Neurotoxicity Study - Other Species Conduct a single dose study in other species to determine the neurotoxicty of your compound.

Non-Human Biospecimen

Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Monkey / Non-Human Primate / NHP Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.

Other Specialty Toxicology

Cutaneous Phototoxicity Study - Other Species Conduct a study in other species to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Ocular Phototoxicity Study - Other Species Conduct a study to determine the extent to which your compound is capable of producing phototoxic side effects in ocular tissues of other species.
Ototoxicity Study - Monkey / Non-human Primate Conduct a study in monkeys/non-human primates to determine the potential for your compound to cause hearing loss.

REACH Services

In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 403: Acute Inhalation Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation.
OECD 405: Acute Eye Irritation/Corrosion This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye.
OECD 410: Repeated Dose Dermal Toxicity: 21/28-day Study This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance.
OECD 411: Subchronic Dermal Toxicity: 90-day Study This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance.
OECD 420: Acute Oral Toxicity - Fixed Dose Procedure A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use...

Show all 9 in REACH Services 3 more

OECD 426: Developmental Neurotoxicity Study A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development.
OECD 451: Carcinogenicity Studies The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test...
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.

Safety Pharmacology

Abuse and Dependence Liability Testing Determine the abuse or dependence potential of a therapeutic.
Abuse Liability Determine the dependence potential of a therapeutic.
CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Dependence Potential Study - Other Species Conduct a study to determine the dependence potential of your compound in other species.
Developmental Neurotoxicty Study - Other Species A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development.
Drug Discrimination Study - Other Species Conduct a study to investigate the length of psychoactive effects of your compound in other species and conduct dose range finding for further studies.

Show all 22 in Safety Pharmacology 16 more

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Implanted Telemetry Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
Implanted Telemetry Study - Other Species Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in other species.
Jacketed External Telemetry (JET) Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
Jacketed External Telemetry (JET) Study - Other Species Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in other species.
Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Repeat Dose Neurotoxicity Study - Other Species Conduct a repeat dose study in other species to determine the neurotoxicity of your compound.
Respiratory Toxicology Assess difficulty breathing, altered respiration, blood gas changes and blood pH issues due to adverse reactions.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Safety Pharmacology Latin Square Study - Monkey / Non-human Primate Conduct a safety pharmacology study with a Latin square design in monkeys/non-human primates.
Safety Pharmacology Study with Functional Observational Batteries (FOBs) - Other Species Conduct a safety pharmacology study with functional oberservational batteries in other species.
Seizure Liability Study - Other Species Conduct a study to determine the seizure risk of your compound in other species.
Self Administration Study - Other Species Conduct a study to investigate the potential addictive characteristics of your compound in other species.
Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.
Telemetry Use implantable or external devices to study physiological parameters in model organisms

Specialty Dosing Routes

Chronic Inhalation Carcinogenicity Study - Other Species Conduct a repeat inhalation dose, chronic carcinogenicity study in other species to determine the tendency of your compound to produce tumors.
Chronic Intravenous Infusion Carcinogenicity Study - Other Species Conduct a repeat intravenous infusion dose, chronic carcinogenicity study in other species to determine the tendency of your compound to produce tumors.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Intra-Articular Toxicology Conduct a study to determine the toxicity and toxicokinetic behavior of your compound when delivered directly to the joint.
Intra-Auricular Toxicology Conduct a study to determine the toxicity and toxicokinetic behavior of your compound when delivered via the ear.
Intracameral Implant Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct an intracameral implant toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.

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Intravitreal Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct an intravitreal ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Other Species Conduct an intravitreal ocular toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Lethal Dose (LD), 50% Toxicity Test Measure acute toxicity by identifying the amount of pure toxin required to kill half of the experimental subjects.
Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.
Repeat Dose Intranasal Study - Monkey / Non-human Primate Conduct a repeat dose intranasal study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Monkey / Non-human Primate Conduct a repeat dose intravenous infusion study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Other Species Conduct a repeat dose intravenous infusion study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Inhalation Study - Other Species Conduct a single dose inhalation study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Other Species Conduct a single dose intranasal study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Other Species Conduct a single dose intravenous infusion study in other species to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Monkeys/Non-human Primates Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to monkeys/non-human primates.
Topical Dermal Toxicity and/or Toxicokinetic Study - Other Species Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to other species.
Topical Ocular Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct a topical ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Target Animal Safety (TAS) Studies Evaluate potential harmful effects associated with the use of a new animal drug in a controlled setting.
Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.

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Alpha Genesis is the leading provider of nonhuman primates and nonhuman primate research resources world-wide. Our offerings include primate research models, research services, bio-products, and housing.Establish Alpha Genesis, Inc. (AGI) as the world’s premier provider of the finest nonhuman primate products and services while maintaining our uncompromising principles as we grow.The following seven guiding principles will help us measure the appropriateness of our decisions:
-Provide the highest standards of care for all animals that we are privileged to maintain.
-Provide a great work environment and treat each other with respect and dignity.
-Embrace diversity as an essential component in the way we do business.
-Apply the highest standards of excellence to the delivery of our products and services.
-Develop enthusiastically satisfied customers all of the time.
-Contribute positively to our communities and to our environment.
-Recognize that profitability is essential to our future success.

Professional associations: SCBIO, SOT
Website: alphagenesisinc.com

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