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METIS Labs
METIS Labs is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
- Medical Imaging Visualize and analyze internal structures in animal models or patients.
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
- SPECT-CT and PET-CT Imaging Get images that combine the spatial context of metabolic or biochemical activity with an anatomic image.
Biomarkers
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Culture Culture primary or immortalized cell lines.
- Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Show all 52 services
Discovery Chemistry
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Disease Models
- Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
- Cognition Models Measure therapeutic endpoints in animal models of cognition.
- Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
- Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
- Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Human Biological Samples
- Human Whole Organs Procure non-transplantable whole human organs or tissues, healthy or diseased, for medical research and development.
In Vitro ADME
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
- Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.
- WBAL (Whole Body AL) Whole Body Autoradioluminography (WBAL) and related services can assist you in determining the metabolic fate of your test agen...
In Vitro Pharmacology
- Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Show all 9 in In Vitro Pharmacology
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
- Protein/Enzyme Targets For requesting Protein/Enzyme Targets
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
In Vivo ADME
- Quantitative Whole Body Autoradiography (QWBA) - Non-rodent Species Conduct a study to determine the tissue distribution of your compound radiolabeled compound in non-rodent species.
In Vivo Pharmacokinetics
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Oncology Models
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Protein Sciences
- Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Safety Pharmacology
- CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
- Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
METIS Labs is a preclinical contract research organization specializing in radioactive drug assays and autoradiography. Our services include: - High-throughput in vitro autoradiography (whole body & single organ) - Ex vivo autoradiography - In vivo receptor occupancy - Radioligand binding assays - Peptide and protein radioiodinations - Custom tritium radiolabeling Our facilities include two fully-equipped modern laboratories (located at Valley Stream and Calverton, NY), animal housing, a broad spectrum NYS radioactive material license and access to an AALAC accredited animal facility...
Show the full description
METIS Labs is a preclinical contract research organization specializing in radioactive drug assays and autoradiography. Our services include:
- High-throughput in vitro autoradiography (whole body & single organ)
- Ex vivo autoradiography
- In vivo receptor occupancy
- Radioligand binding assays
- Peptide and protein radioiodinations
- Custom tritium radiolabeling
Our facilities include two fully-equipped modern laboratories (located at Valley Stream and Calverton, NY), animal housing, a broad spectrum NYS radioactive material license and access to an AALAC accredited animal facility and microPET imaging facilities via a collaboration with Stony Brook University.
- Professional associations
- AAPS, ACS, NYBA
- Website
- metislabs.com
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