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Cyagen Biomodels LLC

Cyagen Biomodels LLC is listed as a small business research supplier in the Scientist.com network, with 4 sites in 2 countries.

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Sites 4

Countries 2

Type of company: Small business

Antibodies

Affinity Maturation Use mutagenesis to optimize a complementary determining region and increase antibody affinity.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Discovery Identifying and developing antibodies that specifically bind to target antigens for therapeutic or diagnostic use.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.

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Antibody Therapy Efficacy In vivo assessment of monoclonal/bispecific antibody efficacy in a humanized mouse
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
Immunodetection Use antibodies to identify a protein or antigen.
Membrane Proteome Array (MPA) Services Use a high-throughput, cell-based platform for profiling antibody specificity that targets human membrane proteins.
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
OmniRat Transgenic Animal Platform Produce humanized antibodies using a transgenic rat platform.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.
Yeast Display Discover or optimize eukaryotic proteins and antibodies that contain post translational modifications

Biomarkers

Autoantibody Testing Screen for the presence of an autoimmune disorder.
Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

Cell Line Construction Create new recombinant cell lines to exact specifications.
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.

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Chemical and Compound Analysis

Dynamic Mechanical Analysis Measure mechanical properties of solids and polymer melts as a function of time, temperature and frequency.

Chemistry, Manufacturing and Controls (CMC)

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.

Clinical Consulting

Antibody Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...

Developmental and Reproductive Toxicology (DART)

In Vitro Alternative Model for Assessing Reproductive Toxicity Laboratory-based methods used to evaluate the potential harmful effects of substances on reproduction without using live animals.

Disease Models

6-OHDA-Induced Parkinson’s Disease (PD) The 6-OHDA (6-hydroxydopamine) model is a classic, widely used preclinical animal model for studying Parkinson’s Disease (PD)
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Adjuvant-Induced Arthritis in Rat (AIA) The Adjuvant-Induced Arthritis (AIA) model in rats is a widely used preclinical tool for studying autoimmune and inflammatory joint diseases, particularly Rheumatoid Arthritis (RA)
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atherosclerosis Model in ApoE KO Mice The Apolipoprotein E knockout ApoE KO or Apoe mouse model is the most widely used mammalian model for studying human atherosclerosis.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.

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Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Collagen-Induced Arthritis (CIA) The Collagen-Induced Arthritis (CIA) model is the most widely used preclinical animal model for human Rheumatoid Arthritis (RA)
Cyp2f2 Knockout Mouse Study Cyp2f2-mediated lung metabolism.
Dry Eye Models Measure therapeutic endpoints such as tear induction, TBUT, Schirmer strips (tear volume) and cornea staining.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
HFD + CCl4-Induced NASH The HFD + CCl4-induced NASH model combines a high-fat diet and carbon tetrachloride injections to rapidly simulate human non-alcoholic steatohepatitis (NASH/MASH)
House Dust Mite (HDM)-Induced Asthma The House Dust Mite (HDM)-Induced Asthma model is a preclinical in vivo study used to evaluate allergic asthma
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Macular Degeneration Models Use a single animal species to create one or more models for eye disease.
Morris Water Maze Investigate spatial learning and memory in rodents.
MPTP-Induced Parkinson’s Disease (PD) The MPTP-induced Parkinson’s disease (PD) model is a chemically induced animal model widely used in neurobiological research
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
OVA-Induced Active Systemic Anaphylaxis The OVA-induced Active Systemic Anaphylaxis (ASA) model is an in vivo preclinical assay used to study allergic responses and evaluate anti-allergic therapies
Oxazolone (OXA)-Induced Atopic Dermatitis (AD) The Oxazolone (OXA)-induced atopic dermatitis (AD) model is a widely used preclinical animal model in which topical applications of the hapten oxazolone are used to trigger skin inflammation
Oxazolone (OXA)-Induced DTH The Oxazolone (OXA)-induced Delayed-Type Hypersensitivity (DTH) model is a T-cell-mediated allergic reaction primarily used in mice and pigs to study inflammatory skin conditions like contact dermatitis or atopic...
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
SNI Neuropathic Pain The Spared Nerve Injury (SNI) model is a widely used rodent model of peripheral neuropathic pain
Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
Streptozotocin (STZ)-Induced Alzheimer’s (AD) The Streptozotocin (STZ)-Induced Alzheimer's Disease (AD) Model is a widely used, non-transgenic experimental model that mimics the pathophysiology of sporadic (late-onset) Alzheimer's in rodents
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.

Effectiveness

In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

Human Biological Samples

Human iPSC's For requesting human sourced induced pluripotent stem cells.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.

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Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.

In Vitro Assays

3Screen™ 3D In Vitro Services 3Screen™ Platform enables complete 3D cell culture characterization.
Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Anti-thrombin Assays Use clotting and chromogenic assays to detect and classify anti-thrombin deficiency.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.

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Basophil Activation Test A Basophil Activation Test (BAT) is a lab test that measures basophil (a type of white blood cell) activation in response to potential allergens
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
ELISpot Assay and Testing Detect low levels of antigens.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Epigenetic Profiling In Vitro Assays Test for epigenetic modifications and indicator levels via in vitro assays.
Glucose Release Assay Determine free glucose levels in biological samples.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Glycomics Glycomics is the comprehensive study of glycans, in a biological system, such as a cell or organism
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
Immunofocus™ Predict the response to anti PD1/PDL1 directed therapies.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro CAR-T Therapy Chimeric Antigen Receptor T-cell therapy: specialized form of immunotherapy
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Microbiology Study microbes and their role in human health.
Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Pathogen Assays Detect and distinguish viral, bacteria and fungal strains and species.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
PrimeFlow™ RNA Assay Reveal the unique kinetics of mRNA and protein in the same cell and identify expression differences as they change over time in response to stimulus.
Rapid Sterility Testing Automated, instrument-based technologies can be used to detect microbial contamination
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
Serine Protease Assay Detect apoptosis by measuring protease activity.
Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.

In Vitro Pharmacology

Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.

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In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vitro Fertilization Models Measure oocyte maturation, embryo development in culture and sperm fertilizing ability.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
CH50 Assays Measure the functional activity of the classical complement activation pathway in serum or other fluid samples.
Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.

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Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

In Vivo ADME

Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Ocular Distribution Study - Other Species Conduct a study to determine the distribution of your compound in ocular tissues of other species.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Mouse Efficacy Monotherapy Use mouse models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Lab Supplies, Facilities, and Equipment

Research Diets for Laboratory Animals Custom mixing and formulation of laboratory animal diets.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
PiggyBac Transgenic Mouse Service Obtain single-copy transgenic embryos with consistent expression of any desired transgene.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.

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SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Nanotechnology

Nanobodies Use heavy-chain only antibodies to create antigen-specific single variable domain fragments.

Neurotoxicology

Single Dose Acute Neurotoxicity Study - Rat Conduct a single dose study in rats to determine the neurotoxicty of your compound.

Non-Human Biospecimen

Rat Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Oncology Xenografts Xenografts derived from oncological samples.

Primary Market Research

Psychological Research Explores cognitive and emotional drivers of stakeholder behavior. Informs persuasive communication and behavior change strategies.

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Lentivirus Production Develop lentiviruses and production protocols.
Peptide Mapping Confirm the identity, purity, and primary structure of proteins, particularly monoclonal antibodies

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Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.

Raw Materials

Weight Control Active Ingredients Acquire weight control active ingredients active ingredients for making over-the-counter medicines.

REACH Services

In Vitro Skin Sensitization Determine whether a drug or cosmetic product may cause dermal sensitization.
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.

Safety Pharmacology

CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Drug Discrimination Study - Rat Conduct a study to investigate the length of psychoactive effects of your compound in rats and conduct dose range finding for further studies.
Microelectrode Array Neurotoxicity Assays Use microelectrode array to measure neurotoxicity-related activities.
Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
Safety Pharmacology Study with Functional Observational Batteries (FOBs) - Other Species Conduct a safety pharmacology study with functional oberservational batteries in other species.
Self Administration Study - Rat Conduct a study to investigate the potential addictive characteristics of your compound in rats.

Specialty Dosing Routes

Intravitreal Toxicity and/or Toxicokinetic Study - Other Species Conduct an intravitreal ocular toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct a topical ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.

Testing Services

Ex Vivo Eye Irritation Test (EVEIT) Use optical coherence tomography (OCT) to monitor full-thickness recovery of corneal tissue.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.

Other services

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Website: www.cyagen.com

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United States Santa Clara 2 sites

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