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Selvita

Selvita is listed as a mid sized business research supplier in the Scientist.com network, with 9 sites in 4 countries and 4 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 9

Countries 4

Type of company: Mid sized business

Agricultural Sciences Compliance and Quality Control Measures

Pesticide Product Testing Use laboratory assays to evaluate the efficacy, safety and selectivity of a pesticide under GLP standards.

Agricultural Sciences Research & Development

Agro-product Storage Stability Testing Monitor agro-product changes over time to optimize packaging, storage conditions and product longevity.
Agrochemical Analytical Method Development Engineer sensitive and selective methods that meet GLP validation requirements to assess different agrochemical properties.
Agrochemical Physio-Chemical Testing Conduct extensive property characterization of agrochemicals for geo-specific product approval and registration.
General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.

Antibodies

Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Immunodetection Use antibodies to identify a protein or antigen.

Biomarkers

Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.

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Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Complete Blood Count Set of medical laboratory tests that provide information about the cells in blood.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Peptide Bioanalysis Analyze the structure of Peptides.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Show all 289 services 275 more

Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.

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Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.

Show all 41 in Chemical and Compound Analysis 35 more

Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Gas Chromatography Gas chromatography is an analytical technique that separates, identifies, and quantifies compounds in a mixture
GC MS Analysis Use gas chromatography coupled to mass spectrometry to analyze compound integrity.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Hot Stage Microscopy (HSM) Visualize and characterize temperature-dependent phase transitions in pharmaceutical solids, polymers, and amorphous dispersions using polarized light microscopy coupled with a controlled thermal stage.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Ion Exchange Chromatography Separate and detect analytes.
Isothermal Titration Calorimetry An ITC assay will be established and optimised for the affinity measurement of test substance to target molecule.
Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Photostability Measure drug degradation rates after exposure to various light sources.
Physicochemical Analysis Physicochemical Analysis of material or preparation evaluating (e.g.) particle size, composition, or compound structure.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structural Chemistry Examine the relationship between protein structure and function.
Viscosity Testing Evaluate the fluid flow properties of liquids for product evaluation and quality control.

Chemical and Compound Testing

Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.

Chemistry, Manufacturing and Controls (CMC)

Analytical Development and Validation Request services related to Analytical Development and Validation
API and Drug Product Stability Testing API and Drug Product Stability Testing.
API and drug product storage and release API and drug product storage and release
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)

Show all 18 in Chemistry, Manufacturing and Controls (CMC) 12 more

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Compendial test methods Run Compendial test methods (e.g., KF)
Crystallization studies Crystallization studies
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
ICH-compliant stability testing Perform ICH-compliant stability testing
IND Enabling Package Request a package of Investigational New Drug (IND) Enabling Studies from our group of trusted suppliers that have enrolled in our IND-Enabling Package Program.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Data Science/Bioinformatics

Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.
In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.

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In Silico Protein Modification Analysis Use computational methods to predict the behavior of modified proteins.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.

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Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Leachable and extractable testing Leachable and extractable testing
Leaching and Aged Leaching Assess the leaching potential of products with studies that follow the formation and movement of metabolites or show restricted leaching under simulated use conditions.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
UV and IR Profiling Analyze the integrity of a compound or large biomolecule.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.

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Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Precision Cut Lung Slices (PCLS) Use a phenotypically accurate model of lung behavior for screening and target validation.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Recombinant Nucleosomes Use as substrates in histone methyltransferase or acetyltransferase assays.
RNA Extraction Isolate total RNA or mRNA from cells or tissues

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Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.

General in vivo Toxicology

Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Show all 7 in General in vivo Toxicology 1 more

Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.

Human Biological Samples

HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.

In Vitro ADME

Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.

Show all 18 in In Vitro ADME 12 more

Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.

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Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Glucose Release Assay Determine free glucose levels in biological samples.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Microbiology Study microbes and their role in human health.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.

In Vitro Pharmacology

ATP Competitive Study Determine whether or not a compound is competitive with ATP.
Cellular Thermal Shift Assay Use a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.

Show all 13 in In Vitro Pharmacology 7 more

In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Test for effects on cell viability and proliferation

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

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Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

Fresh Functional Human Tissue Efficacy Assays Use fresh functional human tissue to assess pre-clinical efficacy of test compounds.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Oncology Models

Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.

Other Specialty Toxicology

Viral Testing Characterize viral products for functional activity and possible contamination.

Product Orders

Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.

Show all 34 in Protein Sciences 28 more

N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Native Protein Purification Purify native proteins from sources such as tissue & serum.
NMR Determine molecular and protein structure, and validate sample integrity.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Analysis Analyze the structure, activity, interactions and distribution of proteins.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Engineering Alter the features or properties of a protein for a specific purpose.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein mapping Interrogate the entire sequence of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Protein analysis and tagging are key steps in understanding the effects of compounds and treatments on your target disease outc...
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
SILAC Enable incorporation of isotopic labels in proteins for mass spectrometry-based quantitative proteomics.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

REACH Services

In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 407: Repeated Dose 28-day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 410: Repeated Dose Dermal Toxicity: 21/28-day Study This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance.
OECD 452: Chronic Toxicity Studies Evaluate the direct and indirect impact of prolonged and repeated toxin exposure to test organisms.
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.

Scientific Data Services

Data and Text Mining Derive structured data from free text in order to become accessible for data-mining algorithms.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Other services

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Service areas:

Biology Chemistry DMPK Toxicology

Poland Krakow, Kraków 4 sites
Croatia Zagreb 2 sites
United States Cambridge, San Bruno 2 sites
United Kingdom Cambridge 1 site

Selvita is a drug discovery company founded in 2007 in Krakow, Poland. The company offers drug discovery support at every stage of the early discovery phase up to the preclinical research. Currently Selvita employs over 230 scientists, including 80 PhDs, with extensive experience in several areas of life sciences, and offers the following types of projects: Contract chemistry services: medicinal chemistry, custom organic synthesis, scale-up and process chemistry, as well as industrial chemistry Biology services: cell and molecular biology, ADME and pharmacokinetics, biochemistry, analytical...

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Contract chemistry services: medicinal chemistry, custom organic synthesis, scale-up and process chemistry, as well as industrial chemistry
Biology services: cell and molecular biology, ADME and pharmacokinetics, biochemistry, analytical chemistry and method validation
Integrated drug discovery projects combining variety of drug discovery processes from in silico drug design, and synthesis of a target-focused library, SAR and ADME-driven lead optimization and toxicity prediction, followed by complex preclinical _in vitro _development, all tailored to the customer’s needs.
Comparative studies of biosimilar medicinal products, including a wide range of analytical services, as well as molecular biology and biochemistry assays, successfully applied in biosimilar drug development.

Selvita specializes in a broad spectrum of pharmacodynamic in vitro studies used to analyze biosimilar product's activity in comparison to adequate reference compounds. We offer assays that are able to detect even minor changes in biological response to pharmacologically active
substances.

Selvita's laboratories are located in Krakow, Poland and possess the GLP and GMP certification. Drug discovery clients of Selvita include more than fifty large and medium-sized pharmaceutical and biotechnology companies from USA and Europe.

Selvita offices are located in Greater Boston Area, US, Cambridge, UK and Krakow, Poland.

Selvita is listed on the Main Market of Warsaw Stock Exchange (WSE:SLV).

Professional associations: MassBio
Website: www.selvita.com

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