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Dalriada Drug Discovery Inc.
Dalriada Drug Discovery Inc. is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Cell Culture and Characterization
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- Compound Integrity Analyze the identity and purity of small molecule drug candidates.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
- Ion Exchange Chromatography Separate and detect analytes.
- Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
Show all 11 in Chemical and Compound Analysis
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
- Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Data Science/Bioinformatics
- Proteome Data Analysis Find tools for analysis of homology and similarity, protein function and structural properties.
Discovery Chemistry
- Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
- Compound Purchase Buy compounds, building blocks or compound libraries.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Show all 7 in Discovery Chemistry
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
Show all 75 services
DNA & RNA
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Drug Development
- Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
- Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
In Vitro ADME
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Show all 16 in In Vitro ADME
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Cell Proliferation Measure cell number, cell viability and cell division.
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- Microbiology Study microbes and their role in human health.
In Vitro Pharmacology
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Show all 8 in In Vitro Pharmacology
- Target Identification Identify the target(s) of a biologically active substance.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Dynamic Organellar Maps Compare protein maps between two experimental conditions.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Integrated Proteomics Package Process an entire Proteomics Pipeline Project including: Sample Preparation, Target Enrichment, NGS Instrumentation, and Data Analysis from our Bundle of Suppliers
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Show all 16 in Protein Sciences
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Protein Identification Uncover or confirm the identity of a protein.
- Protein mapping Interrogate the entire sequence of a protein.
- Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
- Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
- Quantitative MS Quantify small and large molecules in the pg/ml range
- SILAC Enable incorporation of isotopic labels in proteins for mass spectrometry-based quantitative proteomics.
- Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Scientific Data Services
- Systems Network Analysis Analyze and visualize molecular pathways including gene regulatory, protein-protein and drug-target networks.
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
- Website
- www.dalriadatx.com
Where it operates
Sites by country, with the cities in each.
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Canada 1 site
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