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PKDERM SAS
PKDERM SAS is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country.
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
- Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Effectiveness
- In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.
Human Biological Samples
- 3D InSight™ Liver Microtissues Perform in vitro assessment of islet function for efficacy and toxicity testing.
- Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
In Vitro ADME
- Cell Fractionation Isolate organelles and subcellular components.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Show all 13 in In Vitro ADME
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Multidrug Resistance Identify potential causes of drug-drug interactions.
- Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Show all 46 services
In Vitro Assays
- 3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
- Cell Proliferation Measure cell number, cell viability and cell division.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
In Vitro Pharmacology
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
- Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Other Specialty Toxicology
- Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.
REACH Services
- OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
Testing Services
- In Vitro Claim Substantiation Evaluation using FDA Broad Spectrum and/ or ISO 24443
- In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
- In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
- Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
- OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
- OECD 439: Skin Irritation Test (SIT) Reconstructed Human Epidermis Test (RhE) Method - An in vitro testing method designed to identify chemicals and/or mixtures capable of inducing moderate skin irritation.
Other services
- Human Dendritic Cell (hDC) Model Test and validate the immune-modulating compounds in DC immune pathway models.
- Website
- www.pkderm.com
Where it operates
Sites by country, with the cities in each.
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France 2 sites
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