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XtalPi
XtalPi is listed as a large business research supplier in the Scientist.com network, with 3 sites in 2 countries.
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Sites
3
Countries
2
Logo XtalPi, via Wikimedia Commons, Public domain. Shown to identify the organization; it may be a registered trademark.
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Bioimaging
- Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
- Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Biomarkers
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Chemical and Compound Analysis
- Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chemical Stability Measure the stability of small molecules in solution.
- Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
- Electron Diffraction Measurement (microED) Use electron diffraction patterns to characterize the crystallographic properties of a sample.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
Show all 12 in Chemical and Compound Analysis
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Solid State Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solid samples.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- Structural Chemistry Examine the relationship between protein structure and function.
- Structural Elucidation Determine chemical structure of a compound. Characterization techniques include mass spectrometry, infrared spectroscopy and X-ray crystallography.
Show all 108 services
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Compendial test methods Run Compendial test methods (e.g., KF)
- Crystallization studies Crystallization studies
- Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Show all 10 in Chemistry, Manufacturing and Controls (CMC)
- Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Clinical Trials
- Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.
Data Science/Bioinformatics
- Discovery Databases Databases specifically designed for drug discovery use.
- Discovery In Silico Drug Dynamics Develop In Silico model of a drug candidate with a biological system with applications such as Pro-drug Predictions, ADME-PK Due Diligence, Brain-Barrier Permeability Simulation, Drug Absorption Simulation, In Silico...
- In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
- In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.
Discovery Chemistry
- Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
- Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
- Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
- Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
- Compound Purchase Buy compounds, building blocks or compound libraries.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Show all 23 in Discovery Chemistry
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.
- Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
- Discovery Molecular Modeling and Simulation Analytics Computational methods to model and study the behavior of molecules, from small chemical systems to large biological molecules.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
- In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
- In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
- Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
- QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
- Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
- Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
- Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
DNA & RNA
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Drug Development
- Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
- Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
- Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
- Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
General Marketing
- Database Management Software Facilitate the collection, tracking and processing of biological facts, statistics and observations.
In Vitro ADME
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
- In Vitro ADME in Vitro ADME services
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Show all 9 in In Vitro ADME
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
In Vitro Assays
- 3Screen™ 3D In Vitro Services 3Screen™ Platform enables complete 3D cell culture characterization.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
- Fully Automated Assays Develop and perform assays that require no manual steps
Show all 8 in In Vitro Assays
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- Target Characterization Characterize potential drug targets during the drug discovery process.
In Vitro Toxicology
- Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Medical Communications
- Medical Literature Reviews Systematic searching, appraisal, and synthesis of published scientific literature to generate evidence-based reports on a specific topic, disease, or treatment.
Model Development
- In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.
Nanotechnology
- Nanoparticle Synthesis Create nano-level structures with unique features.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- NMR Determine molecular and protein structure, and validate sample integrity.
- Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Show all 7 in Protein Sciences
- X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Safety Pharmacology
- Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
- Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.
Scientific Data Services
- Data and Text Mining Derive structured data from free text in order to become accessible for data-mining algorithms.
- Machine Learning/ AI Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)
- Molecular Dynamics Software Run simulations that determine time-dependent behaviors of molecular systems.
Specialty Dosing Routes
- Dermal Toxicology Assess toxicity in rodent dermal testing models.
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- New Request
- Qube - High Throughput Screening Screen large compound libraries for ion channel blockers and modulators.
- Website
- www.xtalpi.com/en
Where it operates
Sites by country, with the cities in each.
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China 2 sites
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United States 1 site
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